A novel combination therapy with Cabozantinib and Honokiol effectively inhibits c-Met-Nrf2-induced renal tumor growth through increased oxidative stress [0.03%]
卡博替尼联合Honokiol通过增加氧化应激有效抑制c-Met-Nrf2诱导的肾肿瘤生长
Laxminarayan Rawat,Murugabaskar Balan,Yuzuru Sasamoto et al.
Laxminarayan Rawat et al.
Receptor tyrosine kinase (RTK), c-Met, is overexpressed and hyper active in renal cell carcinoma (RCC). Most of the therapeutic agents mediate cancer cell death through increased oxidative stress. Induction of c-Met in renal cancer cells pr...
HDAC3 aberration-incurred GPX4 suppression drives renal ferroptosis and AKI-CKD progression [0.03%]
组蛋白脱乙酰酶3异常引起的谷光甘肽过氧化物酶4抑制驱动肾细胞铁死亡及急性肾损伤向慢性肾脏病进展
Lijun Zhang,Fang Chen,Jian Dong et al.
Lijun Zhang et al.
Acute kidney injury (AKI) progression to chronic kidney disease (CKD) represents a unique renal disease setting characterized by early renal cellular injury and regulated cell death, and later renal fibrosis, of which the critical role and ...
Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts [0.03%]
无义氧诱导因子B介导内皮氧化应激和炎症促进高血压负荷诱导的小鼠冠状动脉粥样硬化发生发展
Yu Zhang,Jing-Jing Li,Rui Xu et al.
Yu Zhang et al.
Aims: Endothelial dysfunction plays a pivotal role in atherosclerosis, but the detailed mechanism remains incomplete understood. Nogo-B is an endoplasmic reticulum (ER)-localized protein mediating ER-mitochondrial morphol...
Adaptive responses of neuronal cells to chronic endoplasmic reticulum (ER) stress [0.03%]
神经元细胞对慢性内质网(ER) 应激的适应性反应
Thu Nguyen Minh Pham,Natarajan Perumal,Caroline Manicam et al.
Thu Nguyen Minh Pham et al.
Accumulation of misfolded proteins or perturbation of calcium homeostasis leads to endoplasmic reticulum (ER) stress and is linked to the pathogenesis of neurodegenerative diseases. Hence, understanding the ability of neuronal cells to cope...
Defective function of α-ketoglutarate dehydrogenase exacerbates mitochondrial ATP deficits during complex I deficiency [0.03%]
复合体I缺陷时α-酮戊二酸脱氢酶功能异常会加重线粒体ATP不足现象
Gerardo G Piroli,Allison M Manuel,Richard S McCain et al.
Gerardo G Piroli et al.
The NDUFS4 knockout (KO) mouse phenotype resembles the human Complex I deficiency Leigh Syndrome. The irreversible succination of protein thiols by fumarate is increased in select regions of the NDUFS4 KO brain affected by neurodegeneration...
50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis [0.03%]
氧化性应激的50种颜色：一种半胱氨酸氧化还原模式假说
James N Cobley
James N Cobley
Oxidative stress is biochemically complex. Like primary colours, specific reactive oxygen species (ROS) and antioxidant inputs can be mixed to create unique "shades" of oxidative stress. Even a minimal redox module comprised of just 12 (ROS...
Mitochondrial complex I ROS production and redox signaling in hypoxia [0.03%]
缺氧时线粒体复合物I产生的ROS及红ox信号转导
Chidozie N Okoye,Shon A Koren,Andrew P Wojtovich
Chidozie N Okoye
Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is the major process of aerobic respiration. Enzyme complexes of the electron transport chain (ETC) pump protons to generate a protonmotive force (Δp) th...
Cardiomyocyte NOX4 regulates resident macrophage-mediated inflammation and diastolic dysfunction in stress cardiomyopathy [0.03%]
心肌细胞NOX4调控应激性心肌病驻留巨噬细胞介导的炎症和舒张功能障碍
Aleksandr E Vendrov,Han Xiao,Andrey Lozhkin et al.
Aleksandr E Vendrov et al.
In acute sympathetic stress, catecholamine overload can lead to stress cardiomyopathy. We tested the hypothesis that cardiomyocyte NOX4 (NADPH oxidase 4)-dependent mitochondrial oxidative stress mediates inflammation and diastolic dysfuncti...
Corrigendum to "Natural mutations of human XDH promote the nitrite (NO2-)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?" [Redox Biol. 4 (67) (2023) 102864] [0.03%]
关于“人类NDUFAF6基因突变通过激活线粒体呼吸链复合物Ⅳ促进NO介导的铁死亡：抗氧化反应的新机制”一文的勘误(6卷12期(2023)102598号论文)
G Massimo,R S Khambata,T Chapman et al.
G Massimo et al.
Published Erratum
Redox biology. 2023 Nov:67:102925. DOI:10.1016/j.redox.2023.102925 2023
Nitric oxide inhibits FTO demethylase activity to regulate N6-methyladenosine mRNA methylation [0.03%]
一氧化氮通过抑制FTO的去甲基化活性调节m6A RNA甲基化水平
Hannah Petraitis Kuschman,Marianne B Palczewski,Brian Hoffman et al.
Hannah Petraitis Kuschman et al.
N6-methyladenosine (m6A) is the most abundant internal modification on eukaryotic mRNAs. Demethylation of m6A on mRNA is catalyzed by the enzyme fat mass and obesity-associated protein (FTO), a member of the nonheme Fe(II) and 2-oxoglutarat...