Ultrasmall Cu2-xSe nanoparticles alleviate vascular calcification through inhibiting oxidative stress and NF-κB/NLRP3-mediated inflammation [0.03%]
亚硒酸铜纳米颗粒通过抑制氧化应激和NF-κB/NLRP3介导的炎症缓解血管钙化
Ding Liu,Yuanzhi Ye,Zirong Lan et al.
Ding Liu et al.
Vascular calcification, prevalent in patients with chronic kidney disease, atherosclerosis, and diabetes, is strongly associated with elevated cardiovascular morbidity and mortality, highlighting the urgent need for effective treatments. Ox...
The sodium/iodide symporter is a nitrate transporter in the human salivary gland [0.03%]
人类唾液腺中的钠/碘转运体是硝酸盐转运体
Gaia Picozzi,Leo J S Westerberg,Juliane Jurga et al.
Gaia Picozzi et al.
Rationale: The entero-salivary circulation of inorganic nitrate (NO3-) involves the absorption of dietary nitrate in the gut and active uptake from blood by the salivary glands, leading to a 20-25-fold concentration in sa...
Inflammation contributes to trauma-induced coagulopathy by oxidation of multiple clotting factors [0.03%]
炎症通过氧化多种凝血因子导致创伤性凝血病
Chang Yeop Han,Alexander E St John,Jung Heon Kim et al.
Chang Yeop Han et al.
Trauma-induced coagulopathy (TIC) induces anticoagulation and increases bleeding mortality. Inflammation and oxidative stress play an unknown role in TIC. We examined plasma from injured human trauma patients presenting to the Emergency Dep...
JinHyuk Choi,Youngmee Kim,Hiruni Nilshi Indeevarie Abeysiriwardhana et al.
JinHyuk Choi et al.
Pulmonary fibrosis is a progressive and often fatal disease with limited treatment options. Here, we identify a non-hypoxic mechanism for hypoxia-inducible factor 1α (HIF-1α) stabilization as a critical driver of fibrogenesis. Under ambie...
PHGDH-dependent serine metabolism in astrocytes: A key regulator of oxidative stress and pyroptosis in cerebral ischemia-reperfusion injury [0.03%]
胶质细胞中PHGDH依赖性的丝氨酸代谢在脑缺血再灌注损伤中的作用机制研究
Jimeng Zhang,Yaowen Luo,Changcai Xie et al.
Jimeng Zhang et al.
Phosphoglycerate dehydrogenase (PHGDH) is a key molecule in the progression of Alzheimer's disease. Herein, we report that PHGDH exerts a significant influence on cerebral ischemia-reperfusion injury (CIRI). Ischemia-reperfusion injury is p...
Beyond CFTR: Ivacaftor's role in restoring cellular redox balance and preventing ferroptosis [0.03%]
超越CFTR：Ivacaftor在恢复细胞氧化还原平衡和预防铁死亡中的作用
Michela Rubin,Ilaria Artusi,Monica Rossetto et al.
Michela Rubin et al.
Cystic fibrosis (CF), is a genetic disorder caused by dysfunctional Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, characterized by progressive pulmonary decline and elevated oxidative stress and inflammation. CFTR modu...
Persulfidation alters gene regulatory programs and promotes endothelial specification [0.03%]
persulfate化改变基因调控程序并促进内皮细胞分化
Janina Wittig,Ran Xu,Fredy Delgado Lagos et al.
Janina Wittig et al.
Endogenously generated sulfides are conserved among species and tissues and exert multiple effects through diverse mechanisms. Although sulfides have been linked to cell fates, their role in pluripotent stem cell commitment remains unknown....
Corrigendum to "DAPL1 deficiency in mice impairs antioxidant defenses in the RPE and leads to retinal degeneration with AMD-like features" [Red. Biol. 62 (2023) 102675] [0.03%]
关于"DAPL1缺陷导致小鼠RPE抗氧化防御受损及出现类似年龄相关性黄斑变性的视网膜退行性病变"的勘误([红细胞生物学](The title seems to have an error here; the correct term should be "Retinal Biology") 62 (2023) 102675)
Xiaoyin Ma,Huaicheng Chen,Shuhui Jian et al.
Xiaoyin Ma et al.
Published Erratum
Redox biology. 2025 Dec 2:103938. DOI:10.1016/j.redox.2025.103938 2025
NADPH oxidase isoform NOX-2 deficiency affects mitochondrial oxygen consumption and metabolic flexibility [0.03%]
NADPH氧化酶异构体NOX-2缺陷影响线粒体耗氧量和代谢灵活性
Kannathasan Thetchinamoorthy,Diana Wierzbicka,Emilia Waraksa-Zasada et al.
Kannathasan Thetchinamoorthy et al.
Our recent study showed that the intracellular pattern recognition receptor Nlrp3 inflammasome, activated by reactive oxygen species (ROS), regulates metabolism in hematopoietic cells by maintaining proper "tonic activation" of the electron...
The methyltransferase NmbA methylates the low-molecular weight thiol bacillithiol, and displays a specific structural architecture [0.03%]
甲基转移酶NmbA对低分子量硫醇bacillithiol进行甲基化并具有特殊的结构框架
Marta Hammerstad,Erlend Steinvik,Hans-Petter Hersleth
Marta Hammerstad
Low-molecular-weight (LMW) thiols maintain the cellular redox balance and protect cells against reactive species, heavy metals, toxins, and antibiotics. Despite having similar metabolic functions, structurally distinct LMW thiols are widesp...