Language dysfunction and related amyloid-β in Alzheimer's disease mediated by brain functional connectivity changes [0.03%]
阿尔茨海默病相关语言功能障碍及其与脑内淀粉样蛋白异常沉积之间的功能连接机制研究
Jin-Wen Xiao,Jin Wang,Jin-Tao Wang et al.
Jin-Wen Xiao et al.
Background: Language dysfunction occurs early in Alzheimer's disease (AD) and whether amyloid-β pathology is related to language dysfunction remains unclear. Functional connectivity (FC) in language networks is critical ...
Transdiagnostic neuroanatomical risk in schizophrenia: integrating regional vulnerability indices with anthropometric and fitness-based markers of cardiometabolic health [0.03%]
整合体质和体能指标：以精神分裂症跨诊断神经解剖学风险为视角的心血管代谢健康研究
Hannah Rößler,Lara Hamzehpour,Oliver Grimm
Hannah Rößler
Schizophrenia is a multisystem disorder affecting both brain and body, with patients exhibiting substantial somatic comorbidities including obesity, reduced physical fitness, and elevated cardiometabolic risk. While neuroimaging-derived Reg...
Abnormal myelin could be a mediator of childhood-trauma-induced depression: A quantitative synthetic MRI study [0.03%]
异常髓鞘可能是童年创伤引起的抑郁的介导因素：一种定量合成磁共振成像研究
Junyan Wen,Shuqiong Zheng,Zhimin Chen et al.
Junyan Wen et al.
Objectives: Major depressive disorder (MDD) is a prevalent mental illness with unclear underlying pathophysiology that is often linked to childhood trauma. Emerging evidence suggests a potential association between myelin...
Genetic drivers of hippocampal atrophy highlight the role of APOE functional variants and AD polygenicity in Mild Cognitive Impairment [0.03%]
遗传驱动的海马萎缩强调了APOE功能变异体和AD多基因性在轻度认知障碍中的作用
Natalia Vilor-Tejedor,Albert Rodrigo,Patricia Genius et al.
Natalia Vilor-Tejedor et al.
The hippocampus, crucial in cognitive aging and Alzheimer's disease (AD), shows early atrophy during disease progression. This study investigated 5-year trajectories of hippocampal volumes across AD stages, focusing on genetic predispositio...
Brain age gap reduction following exercise mirrors clinical improvements in schizophrenia spectrum disorders [0.03%]
运动干预可缩小精神分裂症谱系障碍患者的脑年龄差距并改善临床症状
Deniz Yilmaz,Sergi Papiol,Daniel Keeser et al.
Deniz Yilmaz et al.
Schizophrenia spectrum disorders (SSD) are associated with accelerated brain aging, reflected in an increased brain age gap. This gap serves as a biomarker, indicating poorer brain health, cognitive deficits, and greater severity in specifi...
OPM-MEG in multiple sclerosis: Proof of principle, and the effect of naturalistic posture [0.03%]
多发性硬化病的OPM-MEG检查：初步理论及自然体位的影响
Benjamin J Sanders,Christopher G S Gilmartin,Lukas Rier et al.
Benjamin J Sanders et al.
Multiple Sclerosis (MS) is a common neurological disorder in which myelin damage affects neuronal signalling. Magnetoencephalography (MEG - the measurement of magnetic fields generated by neuronal currents) offers metrics of brain function ...
Deep convolutional neural networks outperform vanilla machine learning when predicting language outcomes after stroke [0.03%]
深度卷积神经网络在预测卒中后语言预后方面优于常规机器学习
Thomas M H Hope,Howard Bowman,Alex P Leff et al.
Thomas M H Hope et al.
Background: Current medicine cannot confidently predict patients' language skills after stroke. In recent years, researchers have sought to bridge this gap with machine learning. These models appear to benefit from access...
The impact of prenatal alcohol and tobacco exposure on white matter integrity in 8-12-year-old children [0.03%]
孕期酒精和烟草暴露对8至12岁儿童大脑白质完整性的影响
Annerine Roos,Deborah Jonker,Eric Kan et al.
Annerine Roos et al.
The combined impact of prenatal alcohol exposure (PAE) and prenatal tobacco exposure (PTE) on white-matter integrity in pre-adolescence is poorly understood. We aimed to explore white-matter integrity in children aged 8- to 12-years with PA...
Comparison of thalamic atlases and segmentation techniques in defining motor and sensory nuclei for deep brain stimulation targeting in essential tremor [0.03%]
震颤性必要震颤的深脑刺激靶点定位中运动和感觉核团的丘脑 atlas 和分割方法比较
Mathew E Zilberman,Kelvin L Chou,Parag G Patil et al.
Mathew E Zilberman et al.
Introduction: Many thalamic atlases are available for deep brain stimulation (DBS) applications, but their usage and clinical validation vary. This study investigated the effectiveness of six atlases in DBS targeting for ...
Cortical tortuosity as a potential clinical biomarker for Alzheimer's disease: A 3D MRI analysis of brain morphological changes [0.03%]
皮层扭曲度作为阿尔茨海默病的临床生物标志物的潜力：一种关于大脑形态变化的三维磁共振成像分析方法
Maria-Julieta Mateos,James J Lah,Deqiang Qiu
Maria-Julieta Mateos
Background: Alzheimer's disease (AD) is characterized by progressive brain morphological changes that are not fully captured by traditional volumetric measures. Cortical tortuosity, a novel measure of cortical folding com...