Secreted enzyme uptake masks the in vivo phenotype of macrophage-specific lysosomal acid lipase deletion [0.03%]
分泌酶的摄取掩盖了巨噬细胞特异性溶酶体酸性脂酶缺失的体内表型
Suravi Mukherjee,Melanie Korbelius,Anita Pirchheim et al.
Suravi Mukherjee et al.
Background and hypothesis: Lysosomal acid lipase (LAL) is so far the only known intracellular enzyme that is capable of hydrolyzing triglycerides and cholesteryl esters at an acidic pH inside the lysosome. Mutations in th...
Diego Perez-Tilve,Fa Zhang,Yujin Zhang et al.
Diego Perez-Tilve et al.
Objectives: Functional co- and tri-agonists at the receptors for GLP-1, GIP and glucagon effectively decrease body weight and hyperglycemia but are associated with adverse gastrointestinal effects related to GLP-1R agonis...
Shirine E Usmani,Jean-Philippe Leduc-Gaudet,Stephanie Chau et al.
Shirine E Usmani et al.
The transcriptional repressor B cell lymphoma 6 (BCL6) is highly expressed in skeletal muscle. Although transcriptome-wide studies have shown BCL6 dysregulation in muscular dystrophies, investigations into its endogenous roles in muscle bio...
The plant hormone, 6-benzylaminopurine, ameliorates obesity in male and female mice while on a high-fat diet [0.03%]
植物激素6-苄基腺嘌呤可改善高脂饮食小鼠的肥胖症状
Calvin V Lieu,Cindy X Zhang,Neruja Loganathan et al.
Calvin V Lieu et al.
Obesity is a global health crisis. Currently available treatments, while effective, show several undesirable side effects that hinder their long-term use. Herein, we investigated the anti-obesity potential of 6-benzylaminopurine (BAP), a pl...
Epigenetic modulation of the gut-muscle axis in pompe disease: Microbiota fingerprints to cellular and molecular pathomechanisms [0.03%]
庞贝病中肠道-肌肉轴的表观遗传调节：微生物群指纹到细胞和分子病理机制
Marika Venezia,Maria Russo,Paolo Colomba et al.
Marika Venezia et al.
Inter-organ cross-talk is increasingly recognised as a fundamental determinant in the pathogenesis of neurodegenerative and neuromuscular disorders, modulating neuroinflammation, protein misfolding, and cellular dysfunction through systemic...
Regular parental pre-mating exercise reduces offspring white adiposity and is associated with hypothalamic neurodevelopmental changes during lactation [0.03%]
孕期规律锻炼可减少后代白色脂肪并伴随哺乳期下丘脑神经发育改变
Celia Muñoz,Carla Canal,Joel Vizueta et al.
Celia Muñoz et al.
Physical inactivity is highly prevalent worldwide and affects not only individual health but also the health of future generations. However, the impact of pre-mating physical activity, limited to the pre-mating period, on offspring body wei...
Translating the blueprint of cell fate: eIF5A-mediated translation regulates cellular identity in the pancreas [0.03%]
细胞命运蓝图的翻译：eIF5A介导的胰腺细胞身份调控翻译机制
Danielle L Overton,Catharina Bp Villaca,Dorian J Dale et al.
Danielle L Overton et al.
Cellular identity is fundamentally determined by the precise regulation of protein synthesis, which governs growth, differentiation, and function. In the pancreas, the balance between exocrine and endocrine cell types is critical for organ ...
The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism [0.03%]
光学纯胆酸norUDCA可治疗肝纤维化但会损害全身能量代谢
Ioannis Evangelakos,Esther Verkade,Julia K Rohde et al.
Ioannis Evangelakos et al.
Bile acids (BAs) play an important role in systemic metabolic improvements following bariatric surgery. In this study, we found that orally administered norursodeoxycholic acid (norUDCA), a conjugation-resistant C23 derivative of naturally ...
The hypothalamus is an early site of mitochondrial failure and neuro-immune circuit disruption in amyotrophic lateral sclerosis [0.03%]
渐冻症小鼠模型中下丘脑线粒体功能障碍和神经免疫回路失调发生较早
Silvia Scaricamazza,Valentina Nesci,Gianmarco Fenili et al.
Silvia Scaricamazza et al.
Background: Metabolic dysfunction is a defining feature of amyotrophic lateral sclerosis (ALS), emerging early and strongly associated with disease progression and prognosis. While systemic hypermetabolism is well documen...
Extracellular vesicles carrying surface-anchored adiponectin prevent obesity-related metabolic complications by enhancing insulin sensitivity [0.03%]
携带锚定在表面的胰岛素增敏剂对抗肥胖相关代谢并发症的细胞外囊泡
Alexia Blandin,Margot Voisin,Josy Froger et al.
Alexia Blandin et al.
Adiponectin (Adpn) is a potent insulin-sensitizing adipokine with therapeutic promise for type 2 diabetes (T2D) and metabolic dysfunction-associated steatohepatitis (MASH). Its clinical use is limited by challenges in producing stable, bioa...