Adaptive oligodendrogenesis regulates blood-hypothalamus barrier permeability, hypothalamic glucose sensing and systemic glucose homeostasis in male mice [0.03%]
适应性少突胶质细胞发生调节雄性小鼠的血下丘脑屏障通透性，下丘脑葡萄糖感受和全身葡萄糖稳态
Sophie Buller,Emily O Staricoff,Christine Riches et al.
Sophie Buller et al.
Objective: Brain glucose sensing is critical for survival during hypoglycaemia, yet how glucose-sensing neurons access circulating glucose concentrations to maintain glucose homeostasis remains poorly understood. Here we ...
The Locus Coeruleus Calcitonin Receptor Can Be Engaged by Amylin and Calcitonin Gene-Related Peptide to Suppress Feeding Without Inducing Nausea [0.03%]
肾上腺蓝斑降钙素受体可以通过人肽酪氨酸（胰岛素）和降钙素基因相关肽激活来抑制进食而不引起恶心感
Samantha M Fortin,Marcos J Sanchez-Navarro,Jiayin Hu et al.
Samantha M Fortin et al.
Efforts to fully characterize the diversity of mechanisms underlying energy balance control have led to the identification of atypical sites of action for metabolic signals. The locus coeruleus (LC), a major noradrenergic nucleus of the bra...
Sex-specific differences of amlexanox in a mouse model for atherosclerosis and MASLD [0.03%]
氨鲁司特在动脉粥样硬化和MASLD小鼠模型中的性别差异效应研究
Eleonora Mungo,Michelle Haß,Denis Benning et al.
Eleonora Mungo et al.
Objective: Inhibitor-κB kinase epsilon (IKKε) is a non-canonical IκB kinase involved in NF-κB signaling and type I interferon responses. We recently demonstrated sex-dependent effects of IKKε deletion on atherosclero...
Pre-clinical cancer cachexia causes glucose hypermetabolism prior to overt weight loss [0.03%]
癌前消耗症导致葡萄糖过度代谢先于体重减轻现象出现
Emma Frank,Kaspar W Persson,Pauline Morigny et al.
Emma Frank et al.
Purpose: Cancer cachexia is a life-threatening complication of advanced malignancies, driven by profound systemic metabolic reprogramming and anorexia. Insulin action is markedly impaired in patients with cancer and may c...
SAMM50 rs3761472 causes mitochondrial dysfunction and progression of metabolic dysfunction-associated steatotic liver disease [0.03%]
SAMM50(rs3761472)通过引起线粒体功能障碍促进代谢功能障碍相关脂肪性肝病的进展
Suyeon Kim,Young Jin Kim,Nahyun Kim et al.
Suyeon Kim et al.
Mitochondria play a key role in metabolic liver disease, yet how inherited genetic variation perturbs mitochondrial integrity in vivo remains poorly understood. Here, we demonstrate that SAMM50 rs3761472, a population-enriched single-nucleo...
Dirk Weber,Achim Bub
Dirk Weber
N-acetylated amino acids (Ac-AAs) have been repeatedly reported in metabolomics studies of high-intensity exercise, cold-exposed brown adipose tissue (BAT), and various pathological conditions. Despite their recurrent detection, the origins...
Neuronal ketone body utilization couples exercise and time-restricted feeding to cognitive enhancement [0.03%]
神经酮体利用平衡运动和限时进食以增强认知能力
Sebastian F Salathe,Benjamin A Kugler,Edziu Franczak et al.
Sebastian F Salathe et al.
Ketone body metabolism is linked to brain health benefits, including delaying age-related cognitive decline. Exercise, particularly when combined with an overnight fast, stimulates ketone body turnover and improves brain metabolism and cogn...
Muscle in fat trouble: The rise of IMAT in metabolic and musculoskeletal disease [0.03%]
肌藏脂疾患：IMAT(侵入脂肪组织)在代谢和肌肉骨骼疾病中的上升趋势
Vanessa Weik,Andreas L Birkenfeld,Andreas Peter et al.
Vanessa Weik et al.
Intermuscular adipose tissue (IMAT) is increasingly recognized as a contributor to insulin resistance and metabolic dysfunction in type 2 diabetes (T2D). Accumulation of IMAT was found to correlate with impaired skeletal muscle insulin sens...
GPR180 deficiency impairs mitochondrial function and insulin secretion in pancreatic β-cells [0.03%]
GPR180缺乏损害胰腺β细胞的线粒体功能和胰岛素分泌
Matus Antal,Tina Dahlby,Peter Makovicky et al.
Matus Antal et al.
Objectives: G protein-coupled receptor 180 (GPR180) has been implicated in systemic energy metabolism, primarily in adipose tissue and the liver. Given impaired whole-body glucose tolerance following GPR180 dysfunction, w...
Biallelic TXNIP deficiency is associated with a multisystemic metabolic disease [0.03%]
双等位基因TXNIP缺乏与多系统代谢病相关
Julia-Josefine Scholz,Sharlaine Y L Piel,Ioannis Evangelakos et al.
Julia-Josefine Scholz et al.
Thioredoxin-interacting protein (TXNIP) is a protein involved in redox metabolism, but also a key regulator of glucose and lipid metabolism in preclinical models. To date, four patients with biallelic loss-of-function variants in TXNIP have...