Adipocyte Heparan Sulfate Determines Type 2 Diabetes Susceptibility in Mice via FGF1-Mediated Glucose Regulation [0.03%]
脂肪细胞肝素硫酸盐通过FGF1介导的葡萄糖调节决定小鼠2型糖尿病易感性
Chung-Jui Yu,Ariane R Pessentheiner,Sihao Liu et al.
Chung-Jui Yu et al.
Obesity is the principal driver of insulin resistance, and lipodystrophy is also linked with insulin resistance, emphasizing the vital role of adipose tissue in glucose homeostasis. The quality of adipose tissue expansion is a critical dete...
Isotype-selective roles of hepatic acetyl-CoA carboxylases in a mouse model of fatty liver disease [0.03%]
乙酰辅酶A羧化酶在小鼠脂肪肝病模型中的异构体选择性作用
Martina Beretta,Calum S Vancuylenburg,Riya Shrestha et al.
Martina Beretta et al.
Objective: Acetyl-CoA carboxylase enzymes ACC1 and ACC2 promote liver fat storage. Accordingly, ACC inhibition represents a strategy to reverse fatty liver disease and related disorders. Human and rodent studies show that...
TERT expression attenuates metabolic disorders in obese mice by promoting adipose stem and progenitor cell expansion and differentiation [0.03%]
端粒酶逆转录酶表达通过促进肥胖小鼠的脂肪干细胞和前体细胞增殖及分化来缓解代谢紊乱
Laura Braud,Manuel Bernabe,Julien Vernerey et al.
Laura Braud et al.
Background and aims: Adipose tissue (AT) senescence, induced by obesity or aging, leads to a reduced capacity for tissue remodeling and a chronic pro-inflammatory state, which leads to the onset of metabolic pathologies. ...
Salivary extracellular vesicle-derived microRNAs are related to variances in parameters of obesity, taste and eating behaviour [0.03%]
唾液外泌体衍生的微小RNA与肥胖、味觉和进食行为参数的变化相关
Kristin Röhrborn,Anne Hoffmann,Andrea Lorenz et al.
Kristin Röhrborn et al.
Background: Extracellular vesicles (EVs), conveyors of microRNAs, have recently been linked to obesity. As taste is a potent driver of eating behaviour and food intake, it's connection to EVs is of increasing interest. Th...
Evaluation of the effects of metformin on gut functions and microbiota and their contribution to improving glucose tolerance in diabetic mice [0.03%]
二甲双胍对肠道功能和微生物群的影响及其改善小鼠糖耐量的贡献的评估
Murielle Godet,Emmanuelle Meugnier,Oriane Vitalis et al.
Murielle Godet et al.
Although the mechanism of action of the antidiabetic drug metformin is still a matter of discussions, increasing evidence points to a pivotal role of the gut. Aiming to clarify whether metformin-induced changes in the intestinal tract direc...
Furin may contribute to proglucagon processing and Glucagon-Like Peptide-1 production in human alpha cells [0.03%]
人胰岛α细胞中furin可能参与前肠泌素的加工及胰高血糖素样肽1的生成
Janyne Koepke,Wentong Long,Amy Barr et al.
Janyne Koepke et al.
Glucagon-like peptide-1 (GLP-1) supports beta cell health and function by potentiating glucose-dependent insulin production and secretion. While GLP-1 production has been previously documented in human alpha cells, the steps regulating its ...
Dax1 in AgRP neurons regulates thermogenesis via GR-HDAC3-mediated CRFR1 suppression [0.03%]
Dax1通过GR-HDAC3介导的CRFR1抑制在AgRP神经元中调节产热作用
Zhuodu Wei,Jooseon Cha,Seunghee Lee
Zhuodu Wei
Objectives: The arcuate nucleus of the hypothalamus plays a pivotal role in metabolic homeostasis by integrating the functions of AgRP and POMC neurons. Dax1, a nuclear receptor-like transcription factor, is highly enrich...
Activin receptor type IIA/IIB blockade increases muscle mass and strength, but compromises glycemic control in mice [0.03%]
激活素受体IIA和IIB阻滞剂可增加小鼠肌肉质量和力量但会损害糖代谢控制能力
Michala Carlsson,Emma Frank,Joan M Màrmol et al.
Michala Carlsson et al.
Purpose: Blocking the Activin receptor type IIA and B (ActRIIA/IIB) has clinical potential to increase muscle mass and improve glycemic control in obesity, cancer, and aging. However, the impact of blocking ActRIIA/IIB on...
Weight Loss Reverses Obesity-Associated Impairments in Acute Gastrointestinal Stretch-Induced Suppression of Food Intake and Glucose Homeostasis [0.03%]
体重减轻可逆转肥胖引起的急性胃肠容积扩张诱导的摄食抑制及糖代谢紊乱现象
Maigen Bethea,Tyler Cook,Marwa Mommandi et al.
Maigen Bethea et al.
Periodic fasting induced reconstitution of metabolic flexibility improves albuminuria in patients with type 2 diabetes [0.03%]
间歇性禁食诱导的代谢灵活性重建可以改善2型糖尿病患者的白蛋白尿水平
Alba Sulaj,Phong B H Nguyen,Gernot Poschet et al.
Alba Sulaj et al.
Objective: Metabolic inflexibility has been shown to be associated with type 2 diabetes (T2D) and diabetic nephropathy (DN). However, data are lacking, proving that reconstitution of metabolic flexibility by using a 6-mon...