Effects of the glucagon-like peptide-1 receptor agonist PEG-Loxe on diabetic osteoporosis: A mechanistic study [0.03%]
PEG-洛塞葡胺对糖尿病性骨质疏松症的影响：一项机制研究
Lizhi Zhang,Jingjing Hu,Chunxiao Huang et al.
Lizhi Zhang et al.
Background: Diabetic osteoporosis is characterized by disrupted bone remodeling involving impaired osteogenesis and excessive osteoclastic activity. Although glucagon-like peptide-1 receptor agonists (GLP-1RAs) have hypog...
Insulin resistance induced by pesticides is overcome by pancreatic islet adaptation in a mouse model of Parkinson's disease [0.03%]
帕金森病小鼠模型中，胰腺适应克服了农药引起的胰岛素抵抗
Ambrine Arrar,Nour Mesto,Roxane Descaillot et al.
Ambrine Arrar et al.
Exposure to certain pesticides appears to be involved in type 2 diabetes and Parkinson's disease onset which are reported to be epidemiologically associated. While the exact causes of this association and the deleterious mechanisms linking ...
Vagal control of the brain-esophagus axis ameliorates stress-induced esophageal motility dysfunction in male mice [0.03%]
迷走神经控制脑食管轴可缓解雄性小鼠压力引起的食管运动功能障碍
Kun Zhang,Dake Song,Yingying Zhang et al.
Kun Zhang et al.
Mental stress serves as a major contributor to a spectrum of esophageal motility disorders, including distal esophageal spasm (DES), a condition marked by premature contractile activity of the lower esophageal sphincter (LES). These spasms ...
Phosphomannomutase 1 restrains adipose thermogenic programming via inosine signaling [0.03%]
磷甘露糖基转移酶1通过次黄嘌呤核苷酸信号抑制脂肪组织生热编程
Yafen Ye,Rongrong Xu,Tianwen Liu et al.
Yafen Ye et al.
Objectives: Phosphomannomutase 1 (PMM1) is an evolutionarily conserved metabolic enzyme classically linked to mannose metabolism, but its physiological role in adipose tissue remains unknown. This study aimed to define th...
Maternal obesity and the embryonic rewiring of feeding circuits: beyond the hypothalamus [0.03%]
母体肥胖与摄食回路的胚胎重连：超出下丘脑的影响
Dionysios V Chartoumpekis,Aristea Psilopanagioti
Dionysios V Chartoumpekis
Maternal obesity disrupts fetal hypothalamic development by inducing structural changes in feeding circuits, such as reduced hypothalamic precursor proliferation, blunted energy-status sensing, and aberrant wiring of melanocortin pathways, ...
Blocking β-alanine synthesis triggers widespread perturbations of energy and lipid metabolism in the brain [0.03%]
阻断β-丙氨酸合成会引发脑内能量和脂类代谢的广泛变化
Selina Cannon Homaei,Elaheh Mahootchi,Aashish Srivastava et al.
Selina Cannon Homaei et al.
Background: Glutamate decarboxylase-like 1 (GADL1) decarboxylates aspartic acid to β-alanine in several mammalian tissues, particularly in the brain and skeletal muscle. β-alanine is a precursor to the antioxidant and o...
Metabolic plasticity and optimal redox homeostasis are essential for efficient metastatic colonization [0.03%]
代谢可塑性与最佳氧化还原稳态是高效转移定植的必要条件
Ece Grace,Deyu Zou,Romy Böttcher-Loschinski et al.
Ece Grace et al.
Cancer cells dynamically reprogram their metabolism to adapt to changing microenvironmental conditions during tumor growth and metastatic dissemination. Metastasis of solid tumors-the principal cause of cancer-related mortality-is often dri...
GPR75 genetic manipulations in mice reveal central mechanism for weight loss independent of developmental effects [0.03%]
在小鼠中操纵GPR75基因揭示了与发育作用无关的减重的中枢机制
Hua V Lin,Ibragim Gaidarov,Giuseppe Militello et al.
Hua V Lin et al.
Objectives: Human genetic studies have identified GPR75 loss-of-function variants to be strongly protective against obesity, establishing GPR75 as a compelling therapeutic target. However, critical questions remain regard...
Corrigendum to "Desacetyl-alpha-melanocyte stimulating hormone and alpha-melanocyte stimulating hormone are required to regulate energy balance" [Mol Metab 9 (2018) 207-216/29226825] [0.03%]
关于“去乙酰基-α-黑素细胞刺激激素和α-黑素细胞刺激激素调节能量平衡的必要性”[Mol Metab 9 (2018) 207-216/29226825] 的勘误
Kathleen G Mountjoy,Alexandre Caron,Kristina Hubbard et al.
Kathleen G Mountjoy et al.
Published Erratum
Molecular metabolism. 2026 May 6:102380. DOI:10.1016/j.molmet.2026.102380 2026
Increased leptin signaling drives the response of hypothalamic LepRb neurons to diet-induced obesity [0.03%]
胰岛素信号增强驱动下丘脑LepRb神经元对饮食诱导肥胖的反应
James Dell&#x;Orco,Warren Pan,Margaret B Allison et al.
James Dell&#x;Orco et al.
The failure of hyperleptinemia to decrease adiposity in common forms of obesity has led to the notion that impaired leptin receptor (LepRb) signaling ("leptin resistance") might cause obesity. Because LepRb transcriptional signaling plays a...