A UFMylation-COPII axis orchestrates lipid transport in intestinal enterocytes and regulates systemic lipid balance [0.03%]
肠道上皮细胞中的UFMylation-COPII轴调控脂质运输并调节全身脂质平衡
Yaqun Wang,Feng Zhou,Xin Xu et al.
Yaqun Wang et al.
Background: Intestinal lipid absorption and chylomicron secretion are essential for systemic lipid homeostasis, yet the regulatory mechanisms coordinating lipoprotein assembly and ER export remain poorly understood. UFMyl...
Dysregulated glucagon signaling contributes to hypoglycemia after vertical sleeve gastrectomy in mice [0.03%]
小鼠垂直袖状胃切除术后低血糖与胰高血糖素信号紊乱有关
Tyler M Cook,Maigen Bethea,Silvania da Silva Teixeira et al.
Tyler M Cook et al.
Objective: After bariatric surgery, many individuals experience debilitating bouts of hypoglycemia, termed post-bariatric hypoglycemia (PBH). Our mouse model of vertical sleeve gastrectomy (VSG) mimics key aspects of PBH ...
IL-6 Activity is Required for Maximal Catecholamine Release During High-Intensity Exercise in Men [0.03%]
IL-6活性可使男性在高强度运动时肾上腺素释放最大化
Andreas K Ziegler,Tim Schauer,Sara F Myrup et al.
Andreas K Ziegler et al.
High-intensity exercise triggers a coordinated activation of metabolic, endocrine, and immune pathways, yet the mechanisms integrating these responses remain incompletely understood. Interleukin-6 (IL-6), released during exercise, has been ...
Adiponectin preserves follicles through ADIPOR1/ADIPOR2-driven fatty acid metabolism [0.03%]
脂联素通过脂联素受体1和脂联素受体2驱动的脂肪酸代谢保育卵泡
Dae Hyun Lee,Jae Young Shin,Hyeri Park et al.
Dae Hyun Lee et al.
Background: Adiponectin is a key regulator of glucose and lipid metabolism that improves insulin sensitivity and promotes mitochondrial fatty acid oxidation via ADIPOR1 and ADIPOR2. Ovarian lipid accumulation contributes ...
Hepatokines lipocalin 2 and osteopontin drive muscle atrophy in MASH [0.03%]
肝细胞因子脂质运载蛋白2和骨基质磷酸蛋白素驱动MASH肌萎缩发生发展
Amy R Fumo,Simon I Dreher,Pauline Morigny et al.
Amy R Fumo et al.
A bidirectional relationship exists between metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive inflammatory form, metabolic dysfunction-associated steatohepatitis (MASH), and sarcopenia, with each worsening...
Hepatocyte-specific Cas9-mediated editing of G6pc and Slc37a4 elicits comparable biochemical and regulatory responses between glycogen storage disease (GSD) type Ia and Ib mice [0.03%]
肝特异性Cas9介导的G6pc和Slc37a4编辑在I型糖原贮积病(GSD Ia和Ib小鼠)中产生相当的生化和调节反应
Kishore A Krishnamurthy,Ruiqi Xiao,Martijn G S Rutten et al.
Kishore A Krishnamurthy et al.
Glycogen storage disease type I (GSD I) is an autosomal recessive inborn error of carbohydrate metabolism. Patients with GSD type Ia and Ib exhibit overlapping and distinct symptoms and complications. Notably, GSD Ia patients show more seve...
Chronic viral infection aggravates white adipose tissue dysfunction and liver pathology in obesity [0.03%]
慢性病毒感染加重肥胖状态下的白色脂肪组织功能障碍和肝脏病理变化
Katarzyna M Luda,Marianne Agerholm,Si Brask Sonne et al.
Katarzyna M Luda et al.
White adipose tissue (WAT) plays a central role in maintaining systemic metabolic homeostasis by buffering lipid flux throughout the body. Impairment of this lipid-buffering capacity is a hallmark of obesity and has also been observed durin...
Endocannabinoid system and skeletal muscle health: insights from cannabidiol [0.03%]
内源大麻素系统与骨骼肌健康：来自大麻二酚的启示
Anaïs Deglos,Nicolas Saroul,Stéphane Walrand et al.
Anaïs Deglos et al.
The endocannabinoid (EC) system is a complex network comprising endogenous ligands, enzymes responsible for their synthesis and degradation, and various receptors (including CB1 and CB2). Present in many peripheral tissues, including skelet...
Temporal single-cell transcriptional dynamics of murine pancreatic islet remodeling during hyperglycaemia progression [0.03%]
小鼠在高血糖进展过程中的胰岛同细胞转录动态变化
Simran Singh,Musale Krushna Pavan,Luiz F Barella et al.
Simran Singh et al.
Pancreatic islets undergo coordinated cellular remodeling during obesity-induced insulin resistance. However, longitudinal changes across endocrine and non-endocrine compartments remain largely unexplored. We present a comprehensive high-re...
TGFβ activity stabilizes ACC1 to increase de novo lipogenesis in metabolic liver disease [0.03%]
TGFβ活性稳定ACC1以增加代谢性肝病中的从头脂质合成
Brent Mayfield,Yoko Yagashita,Jinku Kang et al.
Brent Mayfield et al.
Metabolic liver disease arises due to dysregulated signaling between hepatocytes and non-parenchymal cells (NPCs). Through parallel RNA sequencing screens in diet-induced and genetic mouse models, backdropped by human transcriptomic data, w...