CaMKIIγ/δ contributes to mitochondrial metabolic adaptation in skeletal muscle during endurance training [0.03%]
钙调神经磷酸酶依赖的CaM激酶II γ/δ亚基在耐力训练中促进骨骼肌线粒体代谢适应性
Ryoka Tsukahara,Yasuo Kitajima,Yuka Ichihashi et al.
Ryoka Tsukahara et al.
Background: Calcium/calmodulin-dependent protein kinase II (CaMKII) is activated in skeletal muscle with exercise, yet its physiological role in endurance training adaptation remains unclear. This study determined whether...
Conserved transcriptional co-regulation of pyrophosphate homeostasis genes governs systemic mineralization factors in mice and humans [0.03%]
调控焦磷酸盐稳态基因保守的转录共调节作用可控制小鼠和人类体内的全身性矿化因素
Virgil Tamatey,Martin Várhegyi,Bence Blaha et al.
Virgil Tamatey et al.
Inorganic pyrophosphate (PPi) is a key inhibitor of ectopic calcification, yet transcriptional regulation of genes controlling its systemic production and degradation (ABCC6, ALPL, ANKH, and ENPP1) remains poorly understood. We hypothesized...
Endurance exercise elicits a hepatic memory associated with improved metabolic function and protein secretion [0.03%]
耐力运动可诱发与改善代谢功能和蛋白质分泌相关的肝脏记忆效应
Yi-Heng Huang,Clay J Weidenhamer,Nasrin Dabirian et al.
Yi-Heng Huang et al.
Endurance exercise protects against metabolic dysfunction-associated steatotic liver disease (MASLD), yet whether these effects persist following cessation of training remains unclear. Here, we employed endurance training cycles in mice to ...
Inhibitor of DNA binding/differentiation 4 deficiency impairs hepatic fatty acid synthesis and is associated with epigenomic alterations in chromatin accessibility [0.03%]
DNA结合/分化抑制子4缺乏损害肝脏脂肪酸合成并与染色质可及性表观基因组改变相关
Yoshikazu Hayashi,Koji Kinoshita,Tsai-Ming Lu et al.
Yoshikazu Hayashi et al.
Inhibitor of DNA binding/differentiation (ID) 4 is a member of the ID family of proteins. ID4 is involved in gene transcriptional regulation during diverse pathophysiological processes, including cellular differentiation, proliferation, and...
High salt supplementation of a MASH-inducing diet causes lean MASH phenotype with increased hepatic urea cycle activity and EIF5A hypusination [0.03%]
高盐饮食通过增加肝脏尿素循环活性和EIF5A的hypusination诱发MASH表型的机理研究
Shaopeiwen Luo,Norihiko Morisawa,Anissa Anindya Widjaja et al.
Shaopeiwen Luo et al.
MASLD/MASH can occur in lean individuals; however, the environmental triggers and molecular mechanisms underlying lean MASH are unclear, and suitable animal models are lacking. Mice fed a Western diet with liquid fructose (WDF) develops obe...
Pik3ip1 mediates Thyroid Hormone-dependent regulation of the PI3K/Akt/mTOR axis in muscle atrophy [0.03%]
PTH通过PIK3IP1介导甲状腺激素依赖性调节肌肉萎缩中的PI3K/AKT/MTOR轴的作用机制研究
Annarita Nappi,Serena Sagliocchi,Federica Restolfer et al.
Annarita Nappi et al.
Skeletal muscle atrophy is driven by an imbalance between anabolic and catabolic signaling pathways, often involving suppression of the PI3K/Akt/mTOR axis. Thyroid Hormones (THs) are key endocrine regulators of skeletal muscle metabolism an...
Metabolite-driven remodeling of hepatic lipid metabolism by the plasticizer di-isononyl phthalate [0.03%]
增塑剂二异葵基苯二甲酸酯通过代谢物重构肝脏脂质代谢
Sini Pitkänen,Henriikka Hakomäki,Olli Kärkkäinen et al.
Sini Pitkänen et al.
Introduction: Phthalates are widely used as plasticizers in consumer products and are suspected to be metabolism-disrupting chemicals. Di-isononyl phthalate (DINP) is commonly recognized as less hazardous substitute for m...
Chronic Choline Restriction Remodels Hepatic Lipid Metabolism and Drives Insulin Resistance through a CD36-ETNPPL Regulatory Axis [0.03%]
慢性胆碱限制重塑肝脂代谢并通过CD36-ETNPPL调控轴驱动胰岛素抵抗
Evan M Paules,Blake Rushing,Israel Aguilar-Ordoñez et al.
Evan M Paules et al.
Chronic choline insufficiency reprograms hepatic metabolism and drives insulin resistance independent of obesity. While complete choline deficiency causes liver injury, the metabolic consequences of sustained, suboptimal intake, observed in...
Chronic semaglutide alters ingestive behavior without impairing taste function in mice [0.03%]
司美格鲁肽慢性给药可改善小鼠摄食行为而不影响味觉功能
Alisha A Acosta,Hillary Ellis,Fang-Yu Hsu et al.
Alisha A Acosta et al.
Glucagon-like peptide-1 receptor (GLP-1R) agonists such as semaglutide are highly effective treatments for obesity, yet the mechanisms by which they reduce food intake remain incompletely understood. Because taste plays a critical role in g...
Shuiling Zhao,Stevens Bontemps,Ryan M Nottingham et al.
Shuiling Zhao et al.
Abstract/objective: RNASET2 is a lysosomal RNase whose enzymatic function is required for early events in lipotoxicity. However, the endogenous RNA substrates of RNASET2 that modulate lipid-induced cell death are not know...