Identification of novel GPCR partners of the central melanocortin signaling [0.03%]
中央黑素皮质激素信号转导的新GPCR伙伴的鉴定
Yunpeng Li,Xiaozhu Wang,Liumei Lu et al.
Yunpeng Li et al.
Objective: Homo- or heterodimerization of G protein-coupled receptors (GPCRs) generally alters the normal functioning of these receptors and mediates their responses to a variety of physiological stimuli in vivo. It is we...
A viral insulin-like peptide is a natural competitive antagonist of the human IGF-1 receptor [0.03%]
一种病毒源的胰岛素样多肽是人IGF-1受体的天然竞争性拮抗剂
Fa Zhang,Emrah Altindis,C Ronald Kahn et al.
Fa Zhang et al.
Objective: Natural sources of molecular diversity remain of utmost importance as a reservoir of proteins and peptides with unique biological functions. We recently identified such a family of viral insulin-like peptides (...
Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis [0.03%]
核受体共抑制因子NCOR1和SMRT对于维持全身代谢稳态是必需的
Megan J Ritter,Izuki Amano,Norihiro Imai et al.
Megan J Ritter et al.
Objective: The nuclear receptor corepressor 1 (NCOR1) and the silencing mediator of retinoic acid and thyroid hormone (SMRT, also known as NCOR2) play critical and specific roles in nuclear receptor action. NCOR1, both in...
Enzymatic approaches for profiling cytosine methylation and hydroxymethylation [0.03%]
酶学方法分析胞嘧啶甲基化和羟甲基化水平
Tong Wang,Christian E Loo,Rahul M Kohli
Tong Wang
Background: In mammals, modifications to cytosine bases, particularly in cytosine-guanine (CpG) dinucleotide contexts, play a major role in shaping the epigenome. The canonical epigenetic mark is 5-methylcytosine (5mC), b...
Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network [0.03%]
NEUROG3在人胰腺内分泌基因调控网络的广泛作用
Valérie Schreiber,Reuben Mercier,Sara Jiménez et al.
Valérie Schreiber et al.
Objective: Mice lacking the bHLH transcription factor (TF) Neurog3 do not form pancreatic islet cells, including insulin-secreting beta cells, the absence of which leads to diabetes. In humans, homozygous mutations of NEU...
Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency [0.03%]
Rax表达前体细胞衍生的新生前列腺素F2α甲基酯型神经元可缓解先天性促黑素细胞激素缺乏的影响
Surbhi,Gábor Wittmann,Malcolm J Low et al.
Surbhi et al.
Objective: Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus are essential regulators of energy balance. Selective loss of POMC production in these cells results in extreme obesity and metabolic comor...
Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice [0.03%]
小鼠下丘脑糖激酶表达 tan 细胞的消融影响能量平衡并增加肥胖的可能性
Antoine Rohrbach,Emilie Caron,Rafik Dali et al.
Antoine Rohrbach et al.
Objectives: Glucokinase (GCK) is critical for glucosensing. In rats, GCK is expressed in hypothalamic tanycytes and appears to play an essential role in feeding behavior. In this study, we investigated the distribution of...
Novel noncoding RNA CircPTK2 regulates lipolysis and adipogenesis in cachexia [0.03%]
环状RNA CircPTK2通过调节脂肪分解和脂质生成介导恶病质的新机制研究
Zuoyou Ding,Diya Sun,Jun Han et al.
Zuoyou Ding et al.
Objective: Cancer-associated cachexia is a devastating pathological disorder characterized by skeletal muscle wasting and fat storage depletion. Circular RNA, a newly discovered class of noncoding RNAs with important role...
Endothelial BBSome is essential for vascular, metabolic, and retinal functions [0.03%]
内皮BBSome在血管、代谢和视网膜功能中必不可少
Jingwei Jiang,John J Reho,Sajag Bhattarai et al.
Jingwei Jiang et al.
Objectives: Endothelial cells that line the entire vascular system play a pivotal role in the control of various physiological processes, including metabolism. Additionally, endothelial dysfunction is associated with many...
Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin [0.03%]
肝脏mTORC1信号通过激活ATF4作为其对进食和胰岛素的代谢反应的一部分
Vanessa Byles,Yann Cormerais,Krystle Kalafut et al.
Vanessa Byles et al.
Objective: The mechanistic target of rapamycin complex 1 (mTORC1) is dynamically regulated by fasting and feeding cycles in the liver to promote protein and lipid synthesis while suppressing autophagy. However, beyond the...