Recent advances in the application of induced pluripotent stem cell technology to the study of myeloid malignancies [0.03%]
诱导多能干细胞技术在髓系肿瘤研究中的最新进展
Dharamveer Tatwavedi,Andrea Pellagatti,Jacqueline Boultwood
Dharamveer Tatwavedi
Acquired myeloid malignancies are a spectrum of clonal disorders known to be caused by sequential acquisition of genetic lesions in hematopoietic stem and progenitor cells, leading to their aberrant self-renewal and differentiation. The inc...
Site-specific crosslinking reveals Phosphofructokinase-L inhibition drives self-assembly and attenuation of protein interactions [0.03%]
位点特异性交联揭示了磷酸果糖激酶-L抑制驱动自组装和减弱蛋白质相互作用
Athira Sivadas,Eli Fritz McDonald,Sydney O Shuster et al.
Athira Sivadas et al.
Phosphofructokinase is the central enzyme in glycolysis and constitutes a highly regulated step. The liver isoform (PFKL) compartmentalizes during activation and inhibition in vitro and in vivo, respectively. Compartmentalized PFKL is hypot...
Steroidogenic Factor-1 form and function: From phospholipids to physiology [0.03%]
甾体生成因子-1的形式和功能：从磷脂到生理学
Alexis N Campbell,Woong Jae Choi,Ethan S Chi et al.
Alexis N Campbell et al.
Steroidogenic Factor-1 (SF-1, NR5A1) is a member of the nuclear receptor superfamily of ligand-regulated transcription factors, consisting of a DNA-binding domain (DBD) connected to a transcriptional regulatory ligand binding domain (LBD) v...
Phosphorylation impacts GLE1 nuclear localization and association with DDX1 [0.03%]
磷酸化影响GLE1的核定位及其与DDX1的相互作用
Manisha Sharma,Aaron C Mason,T Renee Dawson et al.
Manisha Sharma et al.
Gle1 regulates gene expression at multiple steps from transcription to mRNA export to translation under stressed and non-stressed conditions. To better understand Gle1 function in stressed human cells, specific antibodies were generated tha...
Phosphoinositides take a central stage in regulating blood platelet production and function [0.03%]
磷脂酰肌醇磷酸在调节血液血小板生成和功能中发挥核心作用
Sonia Severin,Marie-Pierre Gratacap,Laura Bouvet et al.
Sonia Severin et al.
Blood platelets are produced by megakaryocytes through a complex program of differentiation and play a critical role in hemostasis and thrombosis. These anucleate cells are the target of antithrombotic drugs that prevent them from clumping ...
Chromatin conformations of HSP12 during transcriptional activation in the Saccharomyces cerevisiae stationary phase [0.03%]
酿酒酵母休眠期HSP12转录激活过程中的染色质构象变化
Yuri D&#x;Alessio,Anna D&#x;Alfonso,Giorgio Camilloni
Yuri D&#x;Alessio
During evolution, living cells have developed sophisticated molecular and physiological processes to cope with a variety of stressors. These mechanisms, which collectively constitute the Environmental Stress Response, involve the activation...
Metabolism configures immune response across multi-systems: Lessons from COVID-19 [0.03%]
代谢配置多系统免疫反应：来自COVID-19的启示
Tinku Gupta,Najumuddin,Dhanya Rajendran et al.
Tinku Gupta et al.
Several studies over the last decade demonstrate the recruitment of immune cells, increased inflammatory cytokines, and chemokine in patients with metabolic diseases, including heart failure, parenchymal inflammation, obesity, tuberculosis,...
Induction of lysophosphatidic acid (LPA) receptor-mediated signaling regulates cell motility and survival to anticancer drugs in cancer cells treated with hydrogen peroxide [0.03%]
过氧化氢处理的癌细胞中lysophosphatidic acid (LPA)受体介导信号的诱导调节细胞迁移和抗癌药物存活率
Miwa Takai,Miyu Takamoto,Yuka Amano et al.
Miwa Takai et al.
Hydrogen peroxide (H2O2) is one of reactive oxygen species (ROS) and promotes malignant properties of cancer cells. Lysophosphatidic acid (LPA) signaling via LPA receptor (LPA1 to LPA6) regulates a variety of cellular functions, such as cel...
A possible role for G-quadruplexes formation and DNA methylation at IMOOD gene promoter in Obsessive Compulsive Disorder [0.03%]
IMOOD基因启动子区G-四链体形成和DNA甲基化在强迫症中的作用研究
Annalaura Sabatucci,Antonio Girella,Martina Di Bartolomeo et al.
Annalaura Sabatucci et al.
Obsessive Compulsive Disorder (OCD) is a mental health condition still classified and diagnosed with subjective interview-based assessments and which molecular clues have not completely been elucidated. We have recently identified a new reg...
A motif in the 5'untranslated region of messenger RNAs regulates protein synthesis in a S6 kinase-dependent manner [0.03%]
一种位于信使RNA的5'非翻译区内的基序以S6激酶依赖的方式调节蛋白质合成
Hyun-Chul Shin,Yury A Bochkov,Kangsan Kim et al.
Hyun-Chul Shin et al.
The 5' untranslated regions (UTRs) in messenger RNAs (mRNAs) play an important role in the regulation of protein synthesis. We had previously identified a group of mRNAs that includes human semaphorin 7A (SEMA7A) whose translation is upregu...