Upstream and downstream pathways of diacylglycerol kinase : Novel phosphatidylinositol turnover-independent signal transduction pathways [0.03%]
二酰基甘油激酶的上游和下游途径：新型磷脂酰肌醇代谢独立信号转导通路
Fumio Sakane,Chiaki Murakami,Hiromichi Sakai
Fumio Sakane
Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) to produce phosphatidic acid (PA). Mammalian DGK comprise ten isozymes (α-κ) that regulate a wide variety of physiological and pathological events. Recently, we revealed that ...
Characterisation of molecular mechanisms for PLCγ2 disease-linked variants [0.03%]
PLCγ2疾病相关变异的分子机制表征
Tom D Bunney,Charis Kampyli,Ashley Gregory et al.
Tom D Bunney et al.
The phospholipase C enzyme PLCγ2 is best characterised in the context of immune cell regulation. Furthermore, many mutations discovered in PLCγ2 have been linked to the development of complex immune disorders as well as resistance to ibru...
S Fiordoro,C Rosano,E Pechkova et al.
S Fiordoro et al.
Epigenetic modulation of the immune response entails modifiable and inheritable modifications that do not modify the DNA sequence. While there have been many studies on epigenetic changes in tumor cells, there is now a growing focus on epig...
Label-free live characterization of mesenchymal stem cell spheroids by biophysical properties measurement [0.03%]
无标签实时测量间充质干细胞球体的生物物理属性以表征细胞活性
P Marrazzo,A Sargenti,R Costa et al.
P Marrazzo et al.
Three-dimensional (3D) cell culture has become a consolidated method in the stem cell field, where mesenchymal stromal stem cells (MSCs) can be used to generate in vitro spheroid aggregates called MSC-Spheroids (MSph). MSph is a floating cl...
Impact of cellular ATP levels on cell viability in response to fluorouracil through lysophosphatidic acid (LPA) receptor-4 (LPA4) and LPA6 in colon cancer cells [0.03%]
细胞内ATP水平通过溶血磷脂酸受体-4和受体-6影响结肠癌细胞对氟尿嘧啶反应的机制研究
Miwa Takai,Mao Yamamoto,Narumi Yashiro et al.
Miwa Takai et al.
Lysophosphatidic acid (LPA) signaling via LPA receptors (LPA1 to LPA6) mediates various aspects of cancer cell behaviors. This study aimed to investigate the variation in intracellular ATP levels and its impact on cell viability in response...
Advancements in unravelling the fundamental function of the ATAD3 protein in multicellular organisms [0.03%]
探究ATAD3蛋白在多细胞生物中的基本功能的进展
Divya Goel,Sudhir Kumar
Divya Goel
ATPase family AAA domain containing protein 3, commonly known as ATAD3 is a versatile mitochondrial protein that is involved in a large number of pathways. ATAD3 is a transmembrane protein that spans both the inner mitochondrial membrane an...
Decoding how receptor tyrosine kinases (RTKs) mediate nuclear calcium signaling [0.03%]
受体酪氨酸激酶介导核内钙离子信号通路的机制研究
María José González Armijos,Thais Fernandes Bassani,Clara Couto Fernandez et al.
María José González Armijos et al.
Calcium (Ca2+) is a highly versatile intracellular messenger that regulates several cellular processes. Although it is unclear how a single-second messenger coordinates various effects within a cell, there is growing evidence that spatial p...
The potential of the nutraceutical berberine in the treatment of hepatocellular carcinoma and other liver diseases such as NAFLD and NASH [0.03%]
小檗碱在治疗肝细胞癌及其他肝脏疾病（如NASH和NAFLD）方面的潜力
Melchiorre Cervello,Giuseppa Augello,Lucio Cocco et al.
Melchiorre Cervello et al.
Hepatocellular carcinoma (HCC) is a common cancer which unfortunately has poor outcomes. Common anti-cancer treatments such as chemotherapy and targeted therapy have not increased patient survival significantly. A common treatment for HCC p...
Lysophosphatidic acid (LPA) receptor-mediated signaling and cellular responses to anticancer drugs and radiation of cancer cells [0.03%]
溶血磷脂酸(LPA)受体介导的信号和细胞对癌症治疗药物及辐射的反应
Hiroko Ikeda,Miwa Takai,Toshifumi Tsujiuchi
Hiroko Ikeda
Lysophosphatidic acid (LPA) is a simple physiological lipid and structurally consists of a fatty, a phosphate and a glycerol. LPA binds to G protein-coupled LPA receptors (LPA1 to LPA6). LPA receptor-mediated signaling mediates a variety of...
Notch-3 affects chemoresistance in colorectal cancer via DNA base excision repair enzymes [0.03%]
notch-3通过dna碱基切除修复酶影响结直肠癌的化学抗性
Dennis C George,Fred E Bertrand,George Sigounas
Dennis C George
Colon cancer is the second leading cause of cancer death. With over 153,000 new CRC cases predicted, it is the third most commonly diagnosed cancer. Early detection can lead to curative surgical intervention, but recurrent and late metastat...