Inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) controls survival, proliferation and cytokine production in mouse peripheral T cells [0.03%]
肌醇三磷酸3激酶B（Itpkb）调控小鼠外周T细胞的存活、增殖和细胞因子产生
Valérie Pouillon,Yoann Maréchal,Christophe Frippiat et al.
Valérie Pouillon et al.
Mice genetically-deficient for the B isoform of the inositol 1,4,5-trisphosphate 3-kinase (or Itpkb) have a severe defect in thymocytes differentiation and thus lack peripheral T cells. In order to study the functional role of Itpkb in peri...
L Braccini,E Ciraolo,M Martini et al.
L Braccini et al.
Epidemiological studies have established a positive correlation between cancer and metabolic disorders, suggesting that aberrant cell metabolism is a common feature of nearly all tumors. To meet their demand of building block molecules, can...
Dilshad H Khan,Sanzida Jahan,James R Davie
Dilshad H Khan
Epigenetics refer to a variety of processes that have long-term effects on gene expression programs without changes in DNA sequence. Key players in epigenetic control are histone modifications and DNA methylation which, in concert with chro...
Sayyed K Zaidi,Daniel J Trombly,Christopher R Dowdy et al.
Sayyed K Zaidi et al.
Focal organization of regulatory machinery within the interphase nucleus is linked to biological responsiveness and perturbed in cancer. Lineage determinant Runx proteins organize and assemble multi-protein complexes at sites of transcripti...
The pancreatic beta cell as a paradigm for advances in inositide research [0.03%]
磷脂酰肌醇在胰岛β细胞研究中的应用及其进展
Christopher J Barker,Per-Olof Berggren
Christopher J Barker
In a previous review for Advances in Enzyme Research (Berggren and Barker, 2008) we outlined the history of our involvement in discovering important roles for inositides in the insulin secreting pancreatic beta cell. In this current apprais...
Adolfo Saiardi
Adolfo Saiardi
Phosphorus in his phosphate PO(4)(3-) configuration is an essential constituent of all life forms. Phosphate diesters are at the core of nucleic acid structure, while phosphate monoester transmits information under the control of protein ki...
Jong Hyuk Yoon,Jaeyoon Kim,Parkyong Song et al.
Jong Hyuk Yoon et al.
Metabolic tissues, including skeletal muscle, adipose tissue and the digestive system, dynamically secrete various factors depending on the metabolic state, communicate with each other and orchestrate functions to maintain body homeostasis....
The newcomer in the integrin family: integrin α9 in biology and cancer [0.03%]
整合素家族的新成员：α9整合素的生物学和癌症研究
Anette M Høye,John R Couchman,Ulla M Wewer et al.
Anette M Høye et al.
Integrins are heterodimeric transmembrane receptors regulating cell-cell and cell-extracellular matrix interactions. Of the 24 integrin heterodimers identified in humans, α9β1 integrin is one of the least studied. α9, together with α4, ...
Diacylglycerol kinase β in neurons: functional implications at the synapse and in disease [0.03%]
神经元中的二酰基甘油激酶β：在突触和疾病中的功能意义
Yasukazu Hozumi,Kaoru Goto
Yasukazu Hozumi
Phosphoinositide cycle plays a pivotal role in neuronal signal transduction. In this cycle, diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) to yield phosphatidic acid (PA). DG and PA acts as important second messengers that r...
Regulation of the DH-PH tandem of guanine nucleotide exchange factor for Rho GTPases by phosphoinositides [0.03%]
鸟苷交换因子RhoGDP-DHF-RHO的DH-PH串联模块受磷脂酰肌醇张量体调节
Julien Viaud,Frédérique Gaits-Iacovoni,Bernard Payrastre
Julien Viaud
Rho GTPases act as molecular switches central in cellular processes such as cytoskeleton dynamics, migration, cell proliferation, growth or survival. Their activation is tightly regulated downstream of cell surface receptors by Guanine nucl...