Joshua C Saldivar,Jessica Bene,Seyed Ali Hosseini et al.
Joshua C Saldivar et al.
The fragile histidine triad protein, Fhit, has a number of reported tumor suppressive functions which include signaling of apoptosis in cancer cells in vitro and in vivo, modulation of the DNA damage response, down-regulation of target onco...
Christopher J Barker,Ingo B Leibiger,Per-Olof Berggren
Christopher J Barker
Over the last two decades we have focused on beta cell signal transduction, bringing many new insights, especially in the context of insulin signal transduction, the role of inositol polyphosphates and the regulation of cytoplasmic free Ca(...
Increased NGAL (Lnc2) expression after chemotherapeutic drug treatment [0.03%]
化疗药物治疗后NGAL(Lnc2)表达量增加
William H Chappell,Stephen L Abrams,Kristin M Stadelman et al.
William H Chappell et al.
Structure-function relationships of autotaxin, a secreted lysophospholipase D [0.03%]
自分泌动员蛋白的结构与功能关系研究 自分泌动员蛋白是一种分泌型溶酶磷脂酶D
Jens Hausmann,Anastassis Perrakis,Wouter H Moolenaar
Jens Hausmann
Autotaxin (ATX or ENPP2) is an ectonucleotide pyrophosphatase/phosphodiesterase (ENPP) that functions as a secreted lysophospholipase D to produce the multifunctional lipid mediator lysophosphatidic acid (LPA) from more complex lysophosphol...
Hyun-Jun Jang,Yong Ryoul Yang,Jung Kuk Kim et al.
Hyun-Jun Jang et al.
Phosphoinositide-specific phospholipase C-γ1 (PLC-γ1) is an important signaling regulator involved in various cellular processes. In brain, PLC-γ1 is highly expressed and participates in neuronal cell functions mediated by neurotrophins....
Molecular mechanisms of fMLP-induced superoxide generation and degranulation in mouse neutrophils [0.03%]
FMLP诱导的小鼠中性粒细胞超氧阴离子生成和脱颗粒的分子机制研究
Yasunori Kanaho,Takanobu Sato,Tsunaki Hongu et al.
Yasunori Kanaho et al.
In this manuscript, involvement of PLD in fMLP-induced superoxide generation and degranulation were re-investigated using PLD(-/-) neutrophils, and the molecular mechanisms of these neutrophil functions were examined. Neither PLD1 nor PLD2 ...
Nuclear phospholipase C β1 signaling, epigenetics and treatments in MDS [0.03%]
低甲基化治疗对MDS中核磷脂酶Cβ1信号传导及表观遗传学的影响
Matilde Y Follo,Sandra Marmiroli,Irene Faenza et al.
Matilde Y Follo et al.
Myelodysplastic syndromes (MDS), clonal hematopoietic stem-cell disorders mainly affecting older adult patients, show ineffective hematopoiesis in one or more of the lineages of the bone marrow. Most MDS are characterized by anemia, and a n...
SHIP2 signalling at the plasma membrane, in the nucleus and at focal contacts [0.03%]
质膜、细胞核和焦斑接触处的SHIP2信号转导
William&#x;s Elong Edimo,Jean-Marie Vanderwinden,Christophe Erneux
William&#x;s Elong Edimo
Phosphoinositide 5-phosphatases are critical enzymes in modulating the concentrations of PI(3,4,5)P(3), PI(4,5)P(2) and PI(3,5)P(2). The SH2 domain containing inositol 5-phosphatases SHIP1 and SHIP2 belong to this family of enzymes very muc...
Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling [0.03%]
ASK1应对各种刺激的活化机制及其在细胞内信号转导中的意义
Shigeru Shiizaki,Isao Naguro,Hidenori Ichijo
Shigeru Shiizaki
Apoptosis signal-regulating kinase 1 (ASK1) is a member of the mitogen-activated protein kinase kinase kinase family. ASK1 activates c-jun N-terminal kinase (JNK) and p38 in response to various stimuli such as oxidative stress, endoplasmic ...
Activation of the mTOR pathway by the amino acid (L)-leucine in the 5q- syndrome and other ribosomopathies [0.03%]
低五号染色体综合征及其他核糖体病中(L)-亮氨酸活化mTOR通路
Jacqueline Boultwood,Bon Ham Yip,Chaitanya Vuppusetty et al.
Jacqueline Boultwood et al.
Patients with the 5q- syndrome and Diamond-Blackfan anemia (DBA) suffer from a severe macrocytic anemia. The 5q- syndrome and DBA are disorders of aberrant ribosome biogenesis (ribosomopathies) and haploinsufficiency of the ribosomal protei...