Nuclear phospholipase C β1 signaling, epigenetics and treatments in MDS [0.03%]
低甲基化治疗对MDS中核磷脂酶Cβ1信号传导及表观遗传学的影响
Matilde Y Follo,Sandra Marmiroli,Irene Faenza et al.
Matilde Y Follo et al.
Myelodysplastic syndromes (MDS), clonal hematopoietic stem-cell disorders mainly affecting older adult patients, show ineffective hematopoiesis in one or more of the lineages of the bone marrow. Most MDS are characterized by anemia, and a n...
SHIP2 signalling at the plasma membrane, in the nucleus and at focal contacts [0.03%]
质膜、细胞核和焦斑接触处的SHIP2信号转导
William&#x;s Elong Edimo,Jean-Marie Vanderwinden,Christophe Erneux
William&#x;s Elong Edimo
Phosphoinositide 5-phosphatases are critical enzymes in modulating the concentrations of PI(3,4,5)P(3), PI(4,5)P(2) and PI(3,5)P(2). The SH2 domain containing inositol 5-phosphatases SHIP1 and SHIP2 belong to this family of enzymes very muc...
Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling [0.03%]
ASK1应对各种刺激的活化机制及其在细胞内信号转导中的意义
Shigeru Shiizaki,Isao Naguro,Hidenori Ichijo
Shigeru Shiizaki
Apoptosis signal-regulating kinase 1 (ASK1) is a member of the mitogen-activated protein kinase kinase kinase family. ASK1 activates c-jun N-terminal kinase (JNK) and p38 in response to various stimuli such as oxidative stress, endoplasmic ...
Activation of the mTOR pathway by the amino acid (L)-leucine in the 5q- syndrome and other ribosomopathies [0.03%]
低五号染色体综合征及其他核糖体病中(L)-亮氨酸活化mTOR通路
Jacqueline Boultwood,Bon Ham Yip,Chaitanya Vuppusetty et al.
Jacqueline Boultwood et al.
Patients with the 5q- syndrome and Diamond-Blackfan anemia (DBA) suffer from a severe macrocytic anemia. The 5q- syndrome and DBA are disorders of aberrant ribosome biogenesis (ribosomopathies) and haploinsufficiency of the ribosomal protei...
Inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) controls survival, proliferation and cytokine production in mouse peripheral T cells [0.03%]
肌醇三磷酸3激酶B（Itpkb）调控小鼠外周T细胞的存活、增殖和细胞因子产生
Valérie Pouillon,Yoann Maréchal,Christophe Frippiat et al.
Valérie Pouillon et al.
Mice genetically-deficient for the B isoform of the inositol 1,4,5-trisphosphate 3-kinase (or Itpkb) have a severe defect in thymocytes differentiation and thus lack peripheral T cells. In order to study the functional role of Itpkb in peri...
L Braccini,E Ciraolo,M Martini et al.
L Braccini et al.
Epidemiological studies have established a positive correlation between cancer and metabolic disorders, suggesting that aberrant cell metabolism is a common feature of nearly all tumors. To meet their demand of building block molecules, can...
Dilshad H Khan,Sanzida Jahan,James R Davie
Dilshad H Khan
Epigenetics refer to a variety of processes that have long-term effects on gene expression programs without changes in DNA sequence. Key players in epigenetic control are histone modifications and DNA methylation which, in concert with chro...
Sayyed K Zaidi,Daniel J Trombly,Christopher R Dowdy et al.
Sayyed K Zaidi et al.
Focal organization of regulatory machinery within the interphase nucleus is linked to biological responsiveness and perturbed in cancer. Lineage determinant Runx proteins organize and assemble multi-protein complexes at sites of transcripti...
The pancreatic beta cell as a paradigm for advances in inositide research [0.03%]
磷脂酰肌醇在胰岛β细胞研究中的应用及其进展
Christopher J Barker,Per-Olof Berggren
Christopher J Barker
In a previous review for Advances in Enzyme Research (Berggren and Barker, 2008) we outlined the history of our involvement in discovering important roles for inositides in the insulin secreting pancreatic beta cell. In this current apprais...
Adolfo Saiardi
Adolfo Saiardi
Phosphorus in his phosphate PO(4)(3-) configuration is an essential constituent of all life forms. Phosphate diesters are at the core of nucleic acid structure, while phosphate monoester transmits information under the control of protein ki...