On the regulation of protein phosphatase 2A and its role in controlling entry into and exit from mitosis [0.03%]
蛋白磷酸酶2A的调控及其在控制进入和退出有丝分裂中的作用
Tim Hunt
Tim Hunt
The process of mitosis involves a comprehensive reorganization of the cell: chromosomes condense, the nuclear envelope breaks down, the mitotic spindle is assembled, cells round up and release their ties to the substrate and so on and so fo...
Willem-Jan Keune,David R Jones,Nullin Divecha
Willem-Jan Keune
Oxidative signaling is important in cellular health, involved in aging and contributes to the development of several diseases such as cancer, neurodegeneration and diabetes. Correct management of reactive oxygen species (ROS) prevents oxida...
Jia Jia Chan,Delphine Flatters,Fernando Rodrigues-Lima et al.
Jia Jia Chan et al.
Members of the RASSF family (RASSF1-10) have been identified as candidate tumour suppressors that are frequently downregulated by promoter hypermethylation in cancers. These proteins carry a common Ras-association (RA) and SARAH domain (RAS...
The novel poly(A) polymerase Star-PAP is a signal-regulated switch at the 3'-end of mRNAs [0.03%]
新型poly(A)聚合酶Star-PAP是调控mRNA多聚腺苷酸尾巴的信号感应分子开关
Weimin Li,Rakesh S Laishram,Richard A Anderson
Weimin Li
The mRNA 3'-untranslated region (3'-UTR) modulates message stability, transport, intracellular location and translation. We have discovered a novel nuclear poly(A) polymerase termed Star-PAP (nuclear speckle targeted PIPKIα regulated-poly(...
Receptor tyrosine kinase signaling mechanisms: Devolving TrkA responses with phosphoproteomics [0.03%]
受体酪氨酸激酶信号转导机制：用磷酸化蛋白质组学剖析TrkA反应
R A Bradshaw,R J Chalkley,J Biarc et al.
R A Bradshaw et al.
Receptor tyrosine kinases (RTKs) function through protein kinase entities located in the intracellular domain of each protomer. Following activation by ligand binding, they selectively form phosphotyrosine residues by autocatalytic modifica...
Becky Tu-Sekine,Hana Goldschmidt,Elizabeth Petro et al.
Becky Tu-Sekine et al.
Given the well-established roles of diacylglycerol (DAG) and phosphatidic acid (PtdOH) in a variety of signaling cascades, it is not surprising that there is an increasing interest in understanding their physiological roles and mechanisms t...
Daniel Ribeiro,Alice Melão,João T Barata
Daniel Ribeiro
Interleukin-7 (IL-7), a cytokine produced in the bone marrow, thymus and other organs, is mandatory for normal human T-cell development and peripheral homeostasis. Different studies, including phase I clinical trials, have indicated the pot...
Deconstructing mTOR complexes in regulation of Glioblastoma Multiforme and its stem cells [0.03%]
mTOR复合物在胶质母细胞瘤及其干细胞调控中的分解组装
Meena Jhanwar-Uniyal,Dhruve Jeevan,Jayson Neil et al.
Meena Jhanwar-Uniyal et al.
Atypical serine-threonine kinase, mTOR (mechanistic target of Rapamycin; originally coined "mammalian TOR"), exists in two distinct multi-protein complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2), that senses and integrates a variety ...
Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS) [0.03%]
氢氘交换质谱(HDX-MS)捕捉I类受体酪氨酸激酶介导的IA类磷脂酰肌醇3-磷酸激酶(PI3K)激活过程中的动态步骤
John E Burke,Roger L Williams
John E Burke
The catalytic subunits of all class IA phosphoinositide 3-kinases (PI3Ks) associate with identical p85-related subunits and phosphorylate PIP2 yielding PIP3, but they can vary greatly in the signaling pathways in which they participate. The...
Stephen B Shears,Jeremy D Weaver,Huanchen Wang
Stephen B Shears
The diphosphoinositol polyphosphates ("inositol pyrophosphates"; PP-InsPs) regulate many cellular processes in eukaryotes, including stress responses, apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, telomere maintenance, ...