Daniel Ribeiro,Alice Melão,João T Barata
Daniel Ribeiro
Interleukin-7 (IL-7), a cytokine produced in the bone marrow, thymus and other organs, is mandatory for normal human T-cell development and peripheral homeostasis. Different studies, including phase I clinical trials, have indicated the pot...
Deconstructing mTOR complexes in regulation of Glioblastoma Multiforme and its stem cells [0.03%]
mTOR复合物在胶质母细胞瘤及其干细胞调控中的分解组装
Meena Jhanwar-Uniyal,Dhruve Jeevan,Jayson Neil et al.
Meena Jhanwar-Uniyal et al.
Atypical serine-threonine kinase, mTOR (mechanistic target of Rapamycin; originally coined "mammalian TOR"), exists in two distinct multi-protein complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2), that senses and integrates a variety ...
Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS) [0.03%]
氢氘交换质谱(HDX-MS)捕捉I类受体酪氨酸激酶介导的IA类磷脂酰肌醇3-磷酸激酶(PI3K)激活过程中的动态步骤
John E Burke,Roger L Williams
John E Burke
The catalytic subunits of all class IA phosphoinositide 3-kinases (PI3Ks) associate with identical p85-related subunits and phosphorylate PIP2 yielding PIP3, but they can vary greatly in the signaling pathways in which they participate. The...
Stephen B Shears,Jeremy D Weaver,Huanchen Wang
Stephen B Shears
The diphosphoinositol polyphosphates ("inositol pyrophosphates"; PP-InsPs) regulate many cellular processes in eukaryotes, including stress responses, apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, telomere maintenance, ...
Joshua C Saldivar,Jessica Bene,Seyed Ali Hosseini et al.
Joshua C Saldivar et al.
The fragile histidine triad protein, Fhit, has a number of reported tumor suppressive functions which include signaling of apoptosis in cancer cells in vitro and in vivo, modulation of the DNA damage response, down-regulation of target onco...
Christopher J Barker,Ingo B Leibiger,Per-Olof Berggren
Christopher J Barker
Over the last two decades we have focused on beta cell signal transduction, bringing many new insights, especially in the context of insulin signal transduction, the role of inositol polyphosphates and the regulation of cytoplasmic free Ca(...
Increased NGAL (Lnc2) expression after chemotherapeutic drug treatment [0.03%]
化疗药物治疗后NGAL(Lnc2)表达量增加
William H Chappell,Stephen L Abrams,Kristin M Stadelman et al.
William H Chappell et al.
Structure-function relationships of autotaxin, a secreted lysophospholipase D [0.03%]
自分泌动员蛋白的结构与功能关系研究 自分泌动员蛋白是一种分泌型溶酶磷脂酶D
Jens Hausmann,Anastassis Perrakis,Wouter H Moolenaar
Jens Hausmann
Autotaxin (ATX or ENPP2) is an ectonucleotide pyrophosphatase/phosphodiesterase (ENPP) that functions as a secreted lysophospholipase D to produce the multifunctional lipid mediator lysophosphatidic acid (LPA) from more complex lysophosphol...
Hyun-Jun Jang,Yong Ryoul Yang,Jung Kuk Kim et al.
Hyun-Jun Jang et al.
Phosphoinositide-specific phospholipase C-γ1 (PLC-γ1) is an important signaling regulator involved in various cellular processes. In brain, PLC-γ1 is highly expressed and participates in neuronal cell functions mediated by neurotrophins....
Molecular mechanisms of fMLP-induced superoxide generation and degranulation in mouse neutrophils [0.03%]
FMLP诱导的小鼠中性粒细胞超氧阴离子生成和脱颗粒的分子机制研究
Yasunori Kanaho,Takanobu Sato,Tsunaki Hongu et al.
Yasunori Kanaho et al.
In this manuscript, involvement of PLD in fMLP-induced superoxide generation and degranulation were re-investigated using PLD(-/-) neutrophils, and the molecular mechanisms of these neutrophil functions were examined. Neither PLD1 nor PLD2 ...