Lipin phosphatidic acid phosphatases: Structure, function, regulation, and disease association [0.03%]
脂磷脂酶：结构、功能、调控及与疾病的关系
Franceine S Welcome,Taisha C M Elizaire,Michael V Airola
Franceine S Welcome
Lipids play essential roles as structural barriers in cell membranes, long-term energy storage, and as signaling molecules. One class of enzymes involved in lipid synthesis are lipins. Lipins are magnesium-dependent phosphatidic acid phosph...
TP53 gene status can promote sensitivity and resistance to chemotherapeutic drugs and small molecule signal transduction inhibitors [0.03%]
TP53基因状态可以促进化疗药物和小分子信号转导抑制剂的敏感性和耐药性
James A McCubrey,Matilde Y Follo,Stefano Ratti et al.
James A McCubrey et al.
TP53 is normally a tumor suppressor. However, it is mutated in at least 50% of human cancers. Usually, we assume that mutation of the TP53 is associated with loss of sensitivity to various drugs as in most cases wild type (WT) TP53 activity...
Insights into phosphatidic acid phosphatase and its potential role as a therapeutic target [0.03%]
磷脂酸磷酸酶研究进展及其作为药物靶点的潜力分析
George M Carman,Geordan J Stukey,Ruta Jog et al.
George M Carman et al.
Phosphatidic acid phosphatase, a conserved eukaryotic enzyme that catalyzes the Mg2+-dependent dephosphorylation of phosphatidic acid to produce diacylglycerol, has emerged as a vital regulator of lipid homeostasis. By controlling the balan...
Molecular basis of JAK kinase regulation guiding therapeutic approaches: Evaluating the JAK3 pseudokinase domain as a drug target [0.03%]
janus激酶的调节机制指导治疗方法：评估jak3假酶结构域作为药物靶点的可能性
Anniina Virtanen,Vivian Kettunen,Kirsikka Musta et al.
Anniina Virtanen et al.
Janus kinases (JAK1-3, TYK2) are critical mediators of cytokine signaling and their role in hematological and inflammatory and autoimmune diseases has sparked widespread interest in their therapeutic targeting. JAKs have unique tandem kinas...
Danielle M Smith,Joseph Choi,Michael J Wolfgang
Danielle M Smith
Mitochondrial long chain fatty acid β-oxidation is a critical central carbon catabolic process. The importance of fatty acid oxidation is made evident by the life-threatening disease associated with diverse inborn errors in the pathway. Wh...
Signaling pathways and bone marrow microenvironment in myelodysplastic neoplasms [0.03%]
骨髓增生异常肿瘤的信号转导通路和骨髓微环境
Eleonora Ceneri,Alessia De Stefano,Irene Casalin et al.
Eleonora Ceneri et al.
Key signaling pathways within the Bone Marrow Microenvironment (BMM), such as Notch, Phosphoinositide-Specific Phospholipase C (PI-PLCs), Transforming Growth Factor β (TGF-β), and Nuclear Factor Kappa B (NF-κB), play a vital role in the ...
The perinucleolar compartment and the oncogenic super-enhancers are part of the same phase-separated structure filled with phosphatidylinositol 4,5bisphosphate and long noncoding RNA HANR [0.03%]
磷脂酰肌醇(4,5)二磷酸和长链非编码RNA HANR填充的相邻亚核仁区隔和致癌超级增强子结构是一个分相结构
Ana Miladinović,Ludovica Antiga,Tomáš Venit et al.
Ana Miladinović et al.
The liquid-liquid phase separation in the cell nucleus regulates various processes such as gene regulation and transcription control, chromatin organization, and DNA repair. A plethora of proteins and RNAs contribute to the formation of bio...
Cellular responses to low nutrient conditions via activation of lysophosphatidic acid (LPA) receptor signaling in gastric cancer cells [0.03%]
胃癌细胞中通过溶血磷脂酸(LPA)受体信号转导激活低营养条件下的细胞反应
Narumi Yashiro,Miwa Takai,Mao Yamamoto et al.
Narumi Yashiro et al.
In the center of the solid tumor, abnormal vascular architecture impedes sufficient blood supply, leading to continuous hypoxia and nutrient deprivation for the tumor cells. Lysophosphatidic acid (LPA) receptor signaling is known to drive a...
A budding yeast-centric view of oxysterol binding protein family function [0.03%]
以芽殖酵母为主的氧甾醇结合蛋白家族功能研究
Xiaohan Yu,Carl J Mousley,Vytas A Bankaitis et al.
Xiaohan Yu et al.
The Trans Golgi Network (TGN)/endosomal system is a sorting center for cargo brought via the anterograde secretory pathway and the endocytic pathway that internalizes material from the plasma membrane. As many of the cargo that transit this...
Grace Q Gong,Madhangopal Anandapadamanaban,Md Saiful Islam et al.
Grace Q Gong et al.
The phosphoinositide 3-kinase (PI3K) superfamily includes lipid kinases (PI3Ks and type III PI4Ks) and a group of PI3K-like Ser/Thr protein kinases (PIKKs: mTOR, ATM, ATR, DNA-PKcs, SMG1 and TRRAP) that have a conserved C-terminal kinase do...