Molecular basis of JAK kinase regulation guiding therapeutic approaches: Evaluating the JAK3 pseudokinase domain as a drug target [0.03%]
janus激酶的调节机制指导治疗方法：评估jak3假酶结构域作为药物靶点的可能性
Anniina Virtanen,Vivian Kettunen,Kirsikka Musta et al.
Anniina Virtanen et al.
Janus kinases (JAK1-3, TYK2) are critical mediators of cytokine signaling and their role in hematological and inflammatory and autoimmune diseases has sparked widespread interest in their therapeutic targeting. JAKs have unique tandem kinas...
Danielle M Smith,Joseph Choi,Michael J Wolfgang
Danielle M Smith
Mitochondrial long chain fatty acid β-oxidation is a critical central carbon catabolic process. The importance of fatty acid oxidation is made evident by the life-threatening disease associated with diverse inborn errors in the pathway. Wh...
Signaling pathways and bone marrow microenvironment in myelodysplastic neoplasms [0.03%]
骨髓增生异常肿瘤的信号转导通路和骨髓微环境
Eleonora Ceneri,Alessia De Stefano,Irene Casalin et al.
Eleonora Ceneri et al.
Key signaling pathways within the Bone Marrow Microenvironment (BMM), such as Notch, Phosphoinositide-Specific Phospholipase C (PI-PLCs), Transforming Growth Factor β (TGF-β), and Nuclear Factor Kappa B (NF-κB), play a vital role in the ...
The perinucleolar compartment and the oncogenic super-enhancers are part of the same phase-separated structure filled with phosphatidylinositol 4,5bisphosphate and long noncoding RNA HANR [0.03%]
磷脂酰肌醇(4,5)二磷酸和长链非编码RNA HANR填充的相邻亚核仁区隔和致癌超级增强子结构是一个分相结构
Ana Miladinović,Ludovica Antiga,Tomáš Venit et al.
Ana Miladinović et al.
The liquid-liquid phase separation in the cell nucleus regulates various processes such as gene regulation and transcription control, chromatin organization, and DNA repair. A plethora of proteins and RNAs contribute to the formation of bio...
Cellular responses to low nutrient conditions via activation of lysophosphatidic acid (LPA) receptor signaling in gastric cancer cells [0.03%]
胃癌细胞中通过溶血磷脂酸(LPA)受体信号转导激活低营养条件下的细胞反应
Narumi Yashiro,Miwa Takai,Mao Yamamoto et al.
Narumi Yashiro et al.
In the center of the solid tumor, abnormal vascular architecture impedes sufficient blood supply, leading to continuous hypoxia and nutrient deprivation for the tumor cells. Lysophosphatidic acid (LPA) receptor signaling is known to drive a...
A budding yeast-centric view of oxysterol binding protein family function [0.03%]
以芽殖酵母为主的氧甾醇结合蛋白家族功能研究
Xiaohan Yu,Carl J Mousley,Vytas A Bankaitis et al.
Xiaohan Yu et al.
The Trans Golgi Network (TGN)/endosomal system is a sorting center for cargo brought via the anterograde secretory pathway and the endocytic pathway that internalizes material from the plasma membrane. As many of the cargo that transit this...
Grace Q Gong,Madhangopal Anandapadamanaban,Md Saiful Islam et al.
Grace Q Gong et al.
The phosphoinositide 3-kinase (PI3K) superfamily includes lipid kinases (PI3Ks and type III PI4Ks) and a group of PI3K-like Ser/Thr protein kinases (PIKKs: mTOR, ATM, ATR, DNA-PKcs, SMG1 and TRRAP) that have a conserved C-terminal kinase do...
Baihui Wang,Qiang Luo,Ohad Medalia
Baihui Wang
The intricate interplay between lamins and chromatin underpins the structural integrity and functional organization of the eukaryotic nucleus. Lamins, type V intermediate filament proteins, form a robust meshwork beneath the inner nuclear m...
Biology of childhood hepatoblastoma and the search for novel treatments [0.03%]
儿童肝母细胞瘤的生物学特性及其新型疗法的研究
Marjut Pihlajoki,Katja Eloranta,Ruth Nousiainen et al.
Marjut Pihlajoki et al.
Our research laboratory has a longstanding interest in developmental disorders and embryonic tumors, and recent efforts have focused on the pathogenesis of pediatric liver tumors. This review focuses on hepatoblastoma (HB), the most common ...
Fructose 1,6-bisphosphatase as a promising target of anticancer treatment [0.03%]
果糖-1,6-二磷酸酶作为抗癌治疗的潜在靶点
Agnieszka Gizak,Bartosz Budziak,Aleksandra Domaradzka et al.
Agnieszka Gizak et al.
Fructose 1,6-bisphosphatase (FBP) is a regulatory enzyme of gluconeogenesis that also influences in a non-catalytic manner - via protein-protein interactions - cell cycle-dependent events, mitochondria biogenesis and polarization, synaptic ...