Finly Philip,Shriya Sahu,Giuseppe Caso et al.
Finly Philip et al.
Phospholipase C-β (PLCβ) enzymes are activated by G proteins in response to agents such as hormones and neurotransmitters, and have been implicated in leukemias and neurological disorders. PLCβ activity causes an increase in intracellula...
Regulation of transient receptor potential channels by the phospholipase C pathway [0.03%]
磷脂酶C通路对瞬时受体电位通道的调节作用
Tibor Rohacs
Tibor Rohacs
Transient Receptor Potential (TRP) channels were discovered while analyzing visual mutants in Drosophila. The protein encoded by the transient receptor potential (trp) gene is a Ca(2+) permeable cation channel activated downstream of the ph...
Potential role for phosphatidylinositol transfer protein (PITP) family in lipid transfer during phospholipase C signalling [0.03%]
磷脂酶C信号转导过程中磷酸肌醇转移蛋白(PITP)家族在脂质转移中的潜在作用
Shamshad Cockcroft,Kathryn Garner
Shamshad Cockcroft
The hallmark of mammalian phosphatidylinositol transfer proteins (PITPs) is to transfer phosphatidylinositol between membrane compartments. In the mammalian genome, there are three genes that code for soluble PITP proteins, PITPα, PITPβ a...
Phospholipase C-related but catalytically inactive protein, PRIP as a scaffolding protein for phospho-regulation [0.03%]
与磷脂酶C相关的但无催化活性的蛋白PRIP作为磷酸化调控的支架蛋白
Goro Sugiyama,Hiroshi Takeuchi,Takashi Kanematsu et al.
Goro Sugiyama et al.
PRIP, phospholipase C (PLC)-related but catalytically inactive protein is a protein with a domain organization similar to PLC-δ1. We have reported that PRIP interacts with the catalytic subunits of protein phosphatase 1 and 2A (PP1c and PP...
On the regulation of protein phosphatase 2A and its role in controlling entry into and exit from mitosis [0.03%]
蛋白磷酸酶2A的调控及其在控制进入和退出有丝分裂中的作用
Tim Hunt
Tim Hunt
The process of mitosis involves a comprehensive reorganization of the cell: chromosomes condense, the nuclear envelope breaks down, the mitotic spindle is assembled, cells round up and release their ties to the substrate and so on and so fo...
Willem-Jan Keune,David R Jones,Nullin Divecha
Willem-Jan Keune
Oxidative signaling is important in cellular health, involved in aging and contributes to the development of several diseases such as cancer, neurodegeneration and diabetes. Correct management of reactive oxygen species (ROS) prevents oxida...
Jia Jia Chan,Delphine Flatters,Fernando Rodrigues-Lima et al.
Jia Jia Chan et al.
Members of the RASSF family (RASSF1-10) have been identified as candidate tumour suppressors that are frequently downregulated by promoter hypermethylation in cancers. These proteins carry a common Ras-association (RA) and SARAH domain (RAS...
The novel poly(A) polymerase Star-PAP is a signal-regulated switch at the 3'-end of mRNAs [0.03%]
新型poly(A)聚合酶Star-PAP是调控mRNA多聚腺苷酸尾巴的信号感应分子开关
Weimin Li,Rakesh S Laishram,Richard A Anderson
Weimin Li
The mRNA 3'-untranslated region (3'-UTR) modulates message stability, transport, intracellular location and translation. We have discovered a novel nuclear poly(A) polymerase termed Star-PAP (nuclear speckle targeted PIPKIα regulated-poly(...
Receptor tyrosine kinase signaling mechanisms: Devolving TrkA responses with phosphoproteomics [0.03%]
受体酪氨酸激酶信号转导机制：用磷酸化蛋白质组学剖析TrkA反应
R A Bradshaw,R J Chalkley,J Biarc et al.
R A Bradshaw et al.
Receptor tyrosine kinases (RTKs) function through protein kinase entities located in the intracellular domain of each protomer. Following activation by ligand binding, they selectively form phosphotyrosine residues by autocatalytic modifica...
Becky Tu-Sekine,Hana Goldschmidt,Elizabeth Petro et al.
Becky Tu-Sekine et al.
Given the well-established roles of diacylglycerol (DAG) and phosphatidic acid (PtdOH) in a variety of signaling cascades, it is not surprising that there is an increasing interest in understanding their physiological roles and mechanisms t...