Nuclear phospholipase C-β1 and diacylglycerol LIPASE-α in brain cortical neurons [0.03%]
脑皮层神经元中的核磷脂酶C-β1和二酰基甘油脂肪酶-α
Gontzal García del Caño,Mario Montaña,Xabier Aretxabala et al.
Gontzal García del Caño et al.
Phosphoinositide (PtdIns) signaling involves the generation of lipid second messengers in response to stimuli in a receptor-mediated manner at the plasma membrane. In neuronal cells of adult brain, the standard model proposes that activatio...
Nigel J Pyne,Jan Ohotski,Robert Bittman et al.
Nigel J Pyne et al.
The enzymes that catalyze formation of the bioactive sphingolipid, sphingosine 1-phosphate, sphingosine kinase 1 and 2, are predictive markers in inflammatory diseases and cancer as evidenced by data from patients, knockout mice and the use...
Sue Goo Rhee
Sue Goo Rhee
Yong Ryoul Yang,Matilde Y Follo,Lucio Cocco et al.
Yong Ryoul Yang et al.
The roles of phosphoinositide-specific phospholipase C (PLC) have been extensively investigated in diverse cell lines and pathological conditions. Among the PLC isozmes, primary PLCs, PLC-β and PLC-γ, are directly activated by receptor ac...
Hae-Young Koh
Hae-Young Koh
Abnormal expression patterns of phospholipase C-β1(PLC-β1) in specific brain areas of patients with schizophrenia, and its high genetic linkage to the disorder implicated a pathogenetical involvement of PLC-β1 signaling system. The schiz...
Toshiaki Kawakami,Wenbin Xiao
Toshiaki Kawakami
Great progress has recently been made in structural and functional research of phospholipase C (PLC)-β. We now understand how PLC-β isoforms (β1-β4) are activated by GTP-bound Gαq downstream of G protein-coupled receptors. Numerous stu...
PLCɛ and the RASSF family in tumour suppression and other functions [0.03%]
PLCɛ和RASSF家族在肿瘤抑制和其他功能中的作用
Jia Jia Chan,Matilda Katan
Jia Jia Chan
Not all proteins implicated in direct binding to Ras appear to have a positive role in the generation and progression of tumours; examples include Phospholipase C epsilon (PLCɛ) and some members of the Ras-association domain family (RASSF)...
Yoshikazu Nakamura,Kaori Kanemarum,Kiyoko Fukami
Yoshikazu Nakamura
Phospholipase C (PLC) is a key enzyme in phosphoinositide turnover, and in the regulation of various cellular events. Among the 13 PLC isozymes, PLCδ1 and PLCδ3 share a high sequence homology, and similar tissue distribution. Recent studi...
Rossano Lattanzio,Mauro Piantelli,Marco Falasca
Rossano Lattanzio
Phospholipases are enzymes that use phospholipids as substrate and are classified in three major classes A, C and D based on the reaction they catalyse. Phosphatidylinositol-specific Phospholipase C enzymes utilize phosphatidylinositol 4,5-...
Phospholipase C zeta (PLCζ): oocyte activation and clinical links to male factor infertility [0.03%]
磷脂酶C泽塔（PLCζ）：卵子激活与男性因素引起的不孕的临床联系
Siti Nornadhirah Amdani,Celine Jones,Kevin Coward
Siti Nornadhirah Amdani
Mounting scientific and clinical evidence supports the key role played by phospholipase C zeta (PLCζ), a sperm-specific protein, in the activation of oocytes following fertilisation. Lacking a pleckstrin homology domain, PLCζ remains the ...