Venkatesh Kota,Hiroko Hama
Venkatesh Kota
Ceramide is a precursor of complex sphingolipids and also plays important roles in cell signaling. With the advances in lipid analytical technologies, the structural diversity of ceramide species have become evident, and the complexity of c...
Tsunaki Hongu,Yasunori Kanaho
Tsunaki Hongu
The small GTPase ADP-ribosylation factor 6 (Arf6) plays pivotal roles in a wide variety of cellular events, including exocytosis, endocytosis, actin cytoskeleton reorganization and phosphoinositide metabolism, in various types of cells. To ...
A new approach to measuring phosphoinositides in cells by mass spectrometry [0.03%]
一种利用质谱法测量细胞内磷脂肌醇的新方法
Anna Kielkowska,Izabella Niewczas,Karen E Anderson et al.
Anna Kielkowska et al.
The phosphoinositide family of phospholipids, defined here as PtdIns, PtdIns3P, PtdIns4P, PtdIns5P, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3, play pivotal roles in organising the location and activity of many differen...
DGKζ under stress conditions: “to be nuclear or cytoplasmic, that is the question” [0.03%]
压力条件下DGKζ："去核或是胞浆，这是个问题"
Kaoru Goto,Toshiaki Tanaka,Tomoyuki Nakano et al.
Kaoru Goto et al.
Eukaryotic cells have evolved to possess a distinct subcellular compartment, the nucleus, separated from the cytoplasm in a manner that allows the precise operation of the chromatin, thereby permitting controlled access to the regulatory el...
A lipidomic perspective on inflammatory macrophage eicosanoid signaling [0.03%]
炎性巨噬细胞白三烯信号转导的脂质组学分析
Paul C Norris,Edward A Dennis
Paul C Norris
Macrophages are central to essential physiological processes including the regulation of innate and adaptive immunity, but they are also central to a number of inflammatory disease states. These immune cells also possess remarkable plastici...
Julian Gomez-Cambronero
Julian Gomez-Cambronero
Phospholipase D (PLD) is a membrane protein with a double role: maintenance of the structural integrity of cellular or intracellular membranes and involvement in cell signaling through the product of the catalytic reaction, PA, and through ...
Class I PI 3-kinases signaling in platelet activation and thrombosis: PDK1/Akt/GSK3 axis and impact of PTEN and SHIP1 [0.03%]
PI3激酶信号转导在血小板活化和血栓形成中的作用：PDK1/Akt/GSK3轴及PTEN与SHIP1的影响
Pierre-Alexandre Laurent,Sonia Severin,Marie-Pierre Gratacap et al.
Pierre-Alexandre Laurent et al.
Class I phosphoinositide 3-kinases (PI3K) have been extensively studied in different models these last years and several isoforms are now promising drug targets to treat cancer and immune diseases. Blood platelets are non-nucleated cells cr...
SHIP2 signaling in normal and pathological situations: Its impact on cell proliferation [0.03%]
SHIP2信号在正常及病理情况下的作用及其对细胞增殖的影响
William&#x;s Elong Edimo,Stéphane Schurmans,Pierre P Roger et al.
William&#x;s Elong Edimo et al.
Phosphoinositide 5-phosphatases are critical enzymes in modulating the concentrations of PI(3,4,5)P3, PI(4,5)P2 and PI(3,5)P2. The SH2 domain containing inositol 5-phosphatases SHIP1 and SHIP2 belong to this family of enzymes that dephospho...
The role of splicing factor mutations in the pathogenesis of the myelodysplastic syndromes [0.03%]
剪接因子突变在骨髓增生异常综合征发病机制中的作用
Jacqueline Boultwood,Hamid Dolatshad,Satya S Varanasi et al.
Jacqueline Boultwood et al.
Accurate pre-mRNA splicing by the spliceosome is a fundamental cellular mechanism required to remove introns that are present in most protein-coding transcripts. The recent discovery of a variety of somatic spliceosomal mutations in the mye...
Molecular mechanisms of fatty acid synthase (FASN)-mediated resistance to anti-cancer treatments [0.03%]
脂肪酸合酶（FASN）介导的抗肿瘤治疗抵抗的分子机制
Xi Wu,Li Qin,Valerie Fako et al.
Xi Wu et al.
Human FASN is the key enzyme required for de novo synthesis of fatty acids. Up-regulated FASN expression has been reported in various human cancers and was thought to contribute to poor prognosis and recurrence of these cancers. Studies usi...