Qifeng Zhang,Michael J O Wakelam
Qifeng Zhang
Lipidomic methodologies have developed such that determination in lipid species content of cells and tissues is increasingly achievable. Adoption of these methods is highlighting the physiological importance of individual lipid molecular sp...
Tissue-specific regulation of 3'-nucleotide hydrolysis and nucleolar architecture [0.03%]
调控3'-核苷酸水解和核仁结构的组织特异性调节
Benjamin H Hudson,John D York
Benjamin H Hudson
Sulfur is an essential micronutrient involved in diverse cellular functions ranging from the control of intracellular redox states to electron transport. Eukaryotes incorporate sulfur by metabolizing inorganic sulfate into the universal sul...
Matilde Y Follo,Irene Faenza,Manuela Piazzi et al.
Matilde Y Follo et al.
Lipid signalling molecules are essential components of the processes that allow one extracellular signal to be transferred inside the nucleus, where specific lipid second messengers elicit reactions capable of regulating gene transcription,...
Insights into mRNA export-linked molecular mechanisms of human disease through a Gle1 structure-function analysis [0.03%]
通过GLE1结构功能分析探讨与mRNA出口相关的人类疾病分子机制的见解
Andrew W Folkmann,T Renee Dawson,Susan R Wente
Andrew W Folkmann
A critical step during gene expression is the directional export of nuclear messenger (m)RNA through nuclear pore complexes (NPCs) to the cytoplasm. During export, Gle1 in conjunction with inositol hexakisphosphate (IP6) spatially regulates...
Masayuki Nagahashi,Nitai C Hait,Michael Maceyka et al.
Masayuki Nagahashi et al.
Sphingosine-1-phosphate (S1P), a pleiotropic bioactive lipid mediator, and the kinase that produces it have now emerged as key regulators of numerous cellular processes involved in inflammation and cancer. Here, we review the importance of ...
Yong Ryoul Yang,Pann-Ghill Suh
Yong Ryoul Yang
O-GlcNAcylation is dynamic and a ubiquitous post-translational modification. O-GlcNAcylated proteins influence fundamental functions of proteins such as protein-protein interactions, altering protein stability, and changing protein activity...
Disentangling biological signaling networks by dynamic coupling of signaling lipids to modifying enzymes [0.03%]
通过信号脂质与修饰酶的动态耦合解缠生物信号网络
Raymond D Blind
Raymond D Blind
An unresolved problem in biological signal transduction is how particular branches of highly interconnected signaling networks can be decoupled, allowing activation of specific circuits within complex signaling architectures. Although signa...
Diverse roles of GSK-3: tumor promoter-tumor suppressor, target in cancer therapy [0.03%]
GSK-3的多种作用：肿瘤促进剂-肿瘤抑制剂及癌症治疗靶点
James A McCubrey,Nicole M Davis,Stephen L Abrams et al.
James A McCubrey et al.
Kenza Snoussi,Michael Kann
Kenza Snoussi
Parvoviruses are serious pathogens but also serve as platforms for gene therapy or for using their lytic activity in experimental cancer treatment. Despite of their growing importance during the last decade little is known on how the viral ...
Kazutaka Sahara,Larissa Kogleck,Hideki Yashiroda et al.
Kazutaka Sahara et al.
In eukaryotic cells, the ubiquitin proteasome system plays important roles in diverse cellular processes. The 26S proteasome is a large enzyme complex that degrades ubiquitinated proteins. It consists of 33 different subunits that form two ...