Targeting signaling pathways in T-cell acute lymphoblastic leukemia initiating cells [0.03%]
T细胞急性淋巴细胞白血病始动细胞信号通路的靶向治疗
Alberto M Martelli,Annalisa Lonetti,Francesca Buontempo et al.
Alberto M Martelli et al.
Leukemia initiating cells (LICs) represent a reservoir that is believed to drive relapse and resistance to chemotherapy in blood malignant disorders. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive neoplastic disorder of immatu...
An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer [0.03%]
RAS GTP酶激活蛋白(RAS_GAP)在癌症中的作用范围不断扩大
Ophélia Maertens,Karen Cichowski
Ophélia Maertens
The RAS pathway is one of the most commonly deregulated pathways in human cancer. Mutations in RAS genes occur in nearly 30% of all human tumors. However in some tumor types RAS mutations are conspicuously absent or rare, despite the fact t...
Alex Toker,Sandra Marmiroli
Alex Toker
Akt/PKB is a key master regulator of a wide range of physiological functions including metabolism, proliferation, survival, growth, angiogenesis and migration and invasion. The Akt protein kinase family comprises three highly related isofor...
Inhibition of diacylglycerol kinases as a physiological way to promote diacylglycerol signaling [0.03%]
抑制二酰甘油激酶作为促进二酰基甘油信号传导的生理途径
Gianluca Baldanzi
Gianluca Baldanzi
Diacylglycerol is a key regulator of cell physiology, controlling the membrane recruitment and activation of signaling molecules. Accordingly, diacylglycerol generation and metabolism are strictly controlled, allowing for localized regulati...
Lucio Cocco
Lucio Cocco
An aspirin a day [0.03%]
一天一颗阿司匹林药片
Philip W Majerus
Philip W Majerus
The title of this article is also its punch line. The thesis that I will prove is that every adult, with a few exceptions, should take one 325 mg aspirin tablet each day. The drug is extraordinary and is beneficial in myriad ways. In this d...
Qifeng Zhang,Michael J O Wakelam
Qifeng Zhang
Lipidomic methodologies have developed such that determination in lipid species content of cells and tissues is increasingly achievable. Adoption of these methods is highlighting the physiological importance of individual lipid molecular sp...
Tissue-specific regulation of 3'-nucleotide hydrolysis and nucleolar architecture [0.03%]
调控3'-核苷酸水解和核仁结构的组织特异性调节
Benjamin H Hudson,John D York
Benjamin H Hudson
Sulfur is an essential micronutrient involved in diverse cellular functions ranging from the control of intracellular redox states to electron transport. Eukaryotes incorporate sulfur by metabolizing inorganic sulfate into the universal sul...
Matilde Y Follo,Irene Faenza,Manuela Piazzi et al.
Matilde Y Follo et al.
Lipid signalling molecules are essential components of the processes that allow one extracellular signal to be transferred inside the nucleus, where specific lipid second messengers elicit reactions capable of regulating gene transcription,...
Insights into mRNA export-linked molecular mechanisms of human disease through a Gle1 structure-function analysis [0.03%]
通过GLE1结构功能分析探讨与mRNA出口相关的人类疾病分子机制的见解
Andrew W Folkmann,T Renee Dawson,Susan R Wente
Andrew W Folkmann
A critical step during gene expression is the directional export of nuclear messenger (m)RNA through nuclear pore complexes (NPCs) to the cytoplasm. During export, Gle1 in conjunction with inositol hexakisphosphate (IP6) spatially regulates...