Kathleen A Dorritie,Robert L Redner,Daniel E Johnson
Kathleen A Dorritie
Signal transducer and activator of transcription proteins (STATs) play vital roles in the regulation of cellular proliferation and survival in normal hematopoietic cells, including hematopoietic stem cells. However, aberrant activation of S...
Pancreatic cancer stem cells: association with cell surface markers, prognosis, resistance, metastasis and treatment [0.03%]
胰腺癌干细胞：与表面标记、预后、耐药性、转移和治疗的关系
Timothy L Fitzgerald,James A McCubrey
Timothy L Fitzgerald
In this review, we will discuss the recent advances in understanding the pancreatic cancer stem cells. Identification and characterization of pancreatic cancer stem cells may aid our ability to improve diagnosis and treatment of pancreatic ...
Targeting breast cancer initiating cells: advances in breast cancer research and therapy [0.03%]
乳腺癌起始细胞的靶向治疗：乳腺癌研究和治疗的新进展
James A McCubrey,Nicole M Davis,Stephen L Abrams et al.
James A McCubrey et al.
Over the past 10 years there have been significant advances in our understanding of breast cancer and the important roles that breast cancer initiating cells (CICs) play in the development and resistance of breast cancer. Breast CICs endowe...
Eukaryotic elongation factor 2 kinase, an unusual enzyme with multiple roles [0.03%]
独特的多功能蛋白激酶——真核生物延长因子2 kinases
Justin W Kenney,Claire E Moore,Xuemin Wang et al.
Justin W Kenney et al.
Eukaryotic elongation factor 2 kinase (eEF2K) is a member of the small group of atypical 'α-kinases'. It phosphorylates and inhibits eukaryotic elongation factor 2, to slow down the elongation stage of protein synthesis, which normally con...
Targeting signaling pathways in T-cell acute lymphoblastic leukemia initiating cells [0.03%]
T细胞急性淋巴细胞白血病始动细胞信号通路的靶向治疗
Alberto M Martelli,Annalisa Lonetti,Francesca Buontempo et al.
Alberto M Martelli et al.
Leukemia initiating cells (LICs) represent a reservoir that is believed to drive relapse and resistance to chemotherapy in blood malignant disorders. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive neoplastic disorder of immatu...
An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer [0.03%]
RAS GTP酶激活蛋白(RAS_GAP)在癌症中的作用范围不断扩大
Ophélia Maertens,Karen Cichowski
Ophélia Maertens
The RAS pathway is one of the most commonly deregulated pathways in human cancer. Mutations in RAS genes occur in nearly 30% of all human tumors. However in some tumor types RAS mutations are conspicuously absent or rare, despite the fact t...
Alex Toker,Sandra Marmiroli
Alex Toker
Akt/PKB is a key master regulator of a wide range of physiological functions including metabolism, proliferation, survival, growth, angiogenesis and migration and invasion. The Akt protein kinase family comprises three highly related isofor...
Inhibition of diacylglycerol kinases as a physiological way to promote diacylglycerol signaling [0.03%]
抑制二酰甘油激酶作为促进二酰基甘油信号传导的生理途径
Gianluca Baldanzi
Gianluca Baldanzi
Diacylglycerol is a key regulator of cell physiology, controlling the membrane recruitment and activation of signaling molecules. Accordingly, diacylglycerol generation and metabolism are strictly controlled, allowing for localized regulati...
Lucio Cocco
Lucio Cocco
An aspirin a day [0.03%]
一天一颗阿司匹林药片
Philip W Majerus
Philip W Majerus
The title of this article is also its punch line. The thesis that I will prove is that every adult, with a few exceptions, should take one 325 mg aspirin tablet each day. The drug is extraordinary and is beneficial in myriad ways. In this d...