The Ras/Rap GTPase activating protein RASA3: from gene structure to in vivo functions [0.03%]
雷帕霉素哺乳动物靶蛋白基因结构及生理功能研究
Stéphane Schurmans,Séléna Polizzi,Ariane Scoumanne et al.
Stéphane Schurmans et al.
RASA3 (or GTPase Activating Protein III, R-Ras GTPase-activating protein, GAP1(IP4BP)) is a GTPase activating protein of the GAP1 subfamily which targets Ras and Rap1. RASA3 was originally purified from pig platelet membranes through its in...
Mario Acunzo,Giulia Romano,Dorothee Wernicke et al.
Mario Acunzo et al.
MicroRNAs (miRNAs) are short non-coding RNAs with a length of ∼22 nucleotides, involved in posttranscriptional regulation of gene expression. Until now, over 2588 miRNAs have been identified in humans and the list is growing. MicroRNAs hav...
Christopher J Barker,Luosheng Li,Martin Köhler et al.
Christopher J Barker et al.
Defects in pancreatic β-cell function and survival are key components in type 2 diabetes (T2D). An age-dependent deterioration in β-cell function has also been observed, but little is known about the molecular mechanisms behind this pheno...
Protein arginine methyltransferases (PRMTs): role in chromatin organization [0.03%]
蛋白质精氨酸甲基转移酶(蛋白精氨酸甲基转移酶(PRMTS)：在染色质组织中的作用
Sanzida Jahan,James R Davie
Sanzida Jahan
The mammalian genome encodes eleven protein arginine methyltransferases (PRMTs) that are involved in the transfer of a methyl group from S-adenosylmethionine (AdoMet) to the guanidino nitrogen of arginine. The substrates for these enzymes r...
Hetero-oligomerization of C2 domains of phospholipase C-related but catalytically inactive protein and synaptotagmin-1 [0.03%]
磷脂酶C相关无活性蛋白C2结构域与Synaptotagmin-1的异寡聚化作用机制研究
DaGuang Wang,Hiroshi Takeuchi,Jing Gao et al.
DaGuang Wang et al.
The C2 domain is a protein module often found in molecules that regulate exocytosis. C2 domains mediate interactions between the parental molecule and Ca(2+), phospholipids, and proteins. Although various molecules have been shown to intera...
Novel approaches to target NF-κB and other signaling pathways in cancer stem cells [0.03%]
针对癌症干细胞中NF-κB和其他信号通路的新型靶向方法
Tamami Ukaji,Kazuo Umezawa
Tamami Ukaji
Recently cancer tissue is considered to consist of large number of balk cancer cells and a small number of cancer stem cells. After surgery, radiotherapy, or chemotherapy, most cancer cells are removed, but if there are still very small num...
PTEN expression and function in adult cancer stem cells and prospects for therapeutic targeting [0.03%]
成人癌症干细胞中PTEN的表达和功能及其治疗靶向的前景
Ludovica Ciuffreda,Italia Falcone,Ursula Cesta Incani et al.
Ludovica Ciuffreda et al.
Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a non-redundant lipid phosphatase that restrains and fine tunes the phosphatidylinositol-3-kinase (PI3K) signaling pathway. PTEN is involved in inherited syndromes, which pr...
James A McCubrey,Lucio Cocco
James A McCubrey
Rita Fragoso,João T Barata
Rita Fragoso
Leukemia stem cells (LSCs) are considered responsible for leukemia initiation, relapse and resistance to chemotherapy. These cells have self-renewal capacity and originate the other cells in the leukemia pool. Therefore, in order to complet...
Fred E Bertrand,James A McCubrey,C William Angus et al.
Fred E Bertrand et al.
Over the past decade, our understanding of the role that Notch-signaling has in tumorigenesis has shifted from leukemogenesis into cancers of solid tumors. Emerging data suggests that in addition to direct effects mediated through the canon...