Stephanie S Dusaban,Joan Heller Brown
Stephanie S Dusaban
Phospholipase C-ε (PLCε) integrates signaling from G-protein coupled receptors (GPCRs) to downstream kinases to regulate a broad range of biological and pathophysiological responses. Relative to other PLCs, PLCε is unique in that it not ...
Bola Olayanju,James Jensen Hampsey,Michael Hampsey
Bola Olayanju
We recently discovered that the Warburg effect, defined by the dramatically enhanced metabolism of glucose to pyruvate, even in well-oxygenated cancer cells, can occur as a consequence of mutations that enhance lipid biosynthesis at the exp...
Diacylglycerol, phosphatidic acid, and their metabolic enzymes in synaptic vesicle recycling [0.03%]
神经递质囊泡循环中的二酰基甘油、磷脂酸及其代谢酶
Becky Tu-Sekine,Hana Goldschmidt,Daniel M Raben
Becky Tu-Sekine
The synaptic vesicle (SV) cycle includes exocytosis of vesicles loaded with a neurotransmitter such as glutamate, coordinated recovery of SVs by endocytosis, refilling of vesicles, and subsequent release of the refilled vesicles from the pr...
Laura Spinelli,Yvonne E Lindsay,Nicholas R Leslie
Laura Spinelli
Small molecule inhibitors of many classes of enzymes, including phosphatases, have widespread use as experimental tools and as therapeutics. Efforts to develop inhibitors against the lipid phosphatase and tumour suppressor, PTEN, was for so...
Comparative Study
Advances in biological regulation. 2015 Jan:57:102-11. DOI:10.1016/j.jbior.2014.09.012 2015
Long Shuang Huang,Viswanathan Natarajan
Long Shuang Huang
Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by alveolar epithelial cell injury, accumulation of fibroblasts/myofibroblasts and deposition of extracellular matrix proteins. Levels of sphingosine-1-phosphate (S1...
Distinct signaling mechanisms of mTORC1 and mTORC2 in glioblastoma multiforme: a tale of two complexes [0.03%]
雷帕霉素复合物1和2在多形性胶质母细胞瘤中的不同信号机制：两个复合体的故事
Meena Jhanwar-Uniyal,John L Gillick,Jayson Neil et al.
Meena Jhanwar-Uniyal et al.
Mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that functions via two multiprotein complexes, namely mTORC1 and mTORC2, each characterized by different binding partners that confer separate functions. mTORC1 function is...
Brittany Carroll,Jane Catalina Donaldson,Lina Obeid
Brittany Carroll
Recently, sphingolipid metabolizing enzymes have emerged as important targets of many chemotherapeutics and DNA damaging agents and therefore play significant roles in mediating the physiological response of the cell to DNA damage. In this ...
Regulation of de novo sphingolipid biosynthesis by the ORMDL proteins and sphingosine kinase-1 [0.03%]
ORMDL蛋白和鞘氨醇激酶-1对从头合成鞘脂的调节作用
Deanna Siow,Manjula Sunkara,Andrew Morris et al.
Deanna Siow et al.
Sphingolipids are a diverse set of structurally and metabolically related lipids that have numerous functions in cell structure and signaling. The regulation of these lipids is critical for normal cell function and disregulation has been im...
Simon J Bulley,Jonathan H Clarke,Alaa Droubi et al.
Simon J Bulley et al.
The family of phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) is emerging from a comparative backwater in inositide signalling into the mainstream, as is their substrate, phosphatidylinositol 5-phosphate (PI5P). Here we review some of ...
Role of formyl peptide receptor 2 in homing of endothelial progenitor cells and therapeutic angiogenesis [0.03%]
形式肽受体2在血管祖细胞定位及治疗性血管生成中的作用
Il Ho Jang,Soon Chul Heo,Yang Woo Kwon et al.
Il Ho Jang et al.
Endothelial progenitor cells (EPCs) hold a great promise as a therapeutic mediator in treatment of ischemic disease conditions. The discovery of EPCs in adult blood has been a cause of significant enthusiasm in the field of endothelial cell...