Inositol(1,4,5)P3 3-kinase isoenzymes: Catalytic properties and importance of targeting to F-actin to understand function [0.03%]
肌醇三磷酸3激酶同工酶：催化性质及F- actin靶向性对理解其功能的重要性
Christophe Erneux,Somadri Ghosh,Sandra Koenig
Christophe Erneux
Inositol(1,4,5)trisphosphate (Ins(1,4,5)P3) 3-kinases (Itpks) catalyze the phosphorylation of inositol(1,4,5)trisphosphate into inositol(1,3,4,5)tetrakisphosphate (Ins(1,3,4,5)P4). Three isoenzymes Itpka/b and c have been identified in huma...
Inositol pyrophosphates modulate cell cycle independently of alteration in telomere length [0.03%]
肌醇焦磷酸盐通过改变端粒长度独立调节细胞周期
Hrvoje Banfic,Vladiana Crljen,Vesna Lukinovic-Skudar et al.
Hrvoje Banfic et al.
Synthesis of inositol pyrophosphates through activation of Kcs1 plays an important role in the signalling response required for cell cycle progression after mating pheromone arrest. Overexpression of Kcs1 doubled the level of inositol pyrop...
Application of genome editing technologies to the study and treatment of hematological disease [0.03%]
基因组编辑技术在血液病研究和治疗中的应用
Andrea Pellagatti,Hamid Dolatshad,Bon Ham Yip et al.
Andrea Pellagatti et al.
Genome editing technologies have advanced significantly over the past few years, providing a fast and effective tool to precisely manipulate the genome at specific locations. The three commonly used genome editing technologies are Zinc Fing...
Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation [0.03%]
鞘氨醇-1-磷酸受体、鞘氨醇激酶和鞘氨醇在癌症和炎症中的作用
Nigel J Pyne,Melissa McNaughton,Stephanie Boomkamp et al.
Nigel J Pyne et al.
Sphingosine kinase (there are two isoforms, SK1 and SK2) catalyses the formation of sphingosine 1-phosphate (S1P), a bioactive lipid that can be released from cells to activate a family of G protein-coupled receptors, termed S1P1-5. In addi...
Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells [0.03%]
EGFR和KRAS及其下游信号通路在胰腺癌及胰腺癌干细胞中的作用
Timothy L Fitzgerald,Kvin Lertpiriyapong,Lucio Cocco et al.
Timothy L Fitzgerald et al.
Pancreatic cancer is currently the fourth most common cancer, is increasing in incidence and soon will be the second leading cause of cancer death in the USA. This is a deadly malignancy with an incidence that approximates the mortality wit...
PI3K signaling in arterial diseases: Non redundant functions of the PI3K isoforms [0.03%]
磷脂酰肌醇-3-激酶信号通路在动脉疾病中的作用：PI3K不同亚型的功能分析
Adrien Lupieri,Natalia Smirnova,Nicole Malet et al.
Adrien Lupieri et al.
Cardiovascular diseases are the most common cause of death around the world. This includes atherosclerosis and the adverse effects of its treatment, such as restenosis and thrombotic complications. The development of these arterial patholog...
Foreword: "The PI3-kinase/Akt pathway: From signaling to diseases" [0.03%]
序言：“PI3-激酶/Akt信号通路从信号转导到疾病”
Bernard Payrastre,Lucio Cocco
Bernard Payrastre
Implication of PI3K/Akt pathway in pancreatic cancer: When PI3K isoforms matter? [0.03%]
磷脂酰肌醇-3-激酶信号通路在胰腺癌中的作用：哪种PI3K同工酶最重要？
Romain Baer,Célia Cintas,Nicole Therville et al.
Romain Baer et al.
Pancreatic cancer belongs to the incurable family of solid cancers. Despite of a recent better understanding its molecular biology, and an increased number of clinical trials, there is still a lack for innovative targeted therapies to fight...
Nisha Kriplani,Miguel A Hermida,Euan R Brown et al.
Nisha Kriplani et al.
In many human cell types, the class I phosphoinositide 3-kinases play key roles in the control of diverse cellular processes including growth, proliferation, survival and polarity. This is achieved through their activation by many cell surf...
PI3K/Akt in platelet integrin signaling and implications in thrombosis [0.03%]
PI3K/Akt在血小板整合素信号转导中的作用及其在血栓形成中的意义
Gianni F Guidetti,Ilaria Canobbio,Mauro Torti
Gianni F Guidetti
Blood platelets are anucleated circulating cells that play a critical role in hemostasis and are also implicated in arterial thrombosis, a major cause of death worldwide. The biological function of platelets strongly relies in their reactiv...