Marco Falasca,Riccardo Ferro
Marco Falasca
Lysophosphatidylinositol (LPI) is a well-known bioactive lipid that is able to activate signalling cascades relevant to cell proliferation, migration, survival and tumourigenesis. It is well-established that the G protein-coupled receptor 5...
SOD1 in neurotoxicity and its controversial roles in SOD1 mutation-negative ALS [0.03%]
铜/锌超氧化物歧化酶(SOD1)在神经毒性中的作用及其在非SOD1突变型肌萎缩侧索硬化症(ALS)中所扮演的争议性角色
Yuki Hayashi,Kengo Homma,Hidenori Ichijo
Yuki Hayashi
Amyotrophic lateral sclerosis (ALS) is a serious neurodegenerative disorder that is characterized by the selective death of motor neurons. While the fundamental cause of the disorder is still unclear, the first identified risk gene, Cu,Zn s...
Suyong Choi,Richard A Anderson
Suyong Choi
Phosphatidylinositol 4,5-bisphosphate (PI4,5P2) is a lipid messenger that regulates a wide variety of cellular functions. The majority of cellular PI4,5P2 is generated by isoforms of the type I phosphatidylinositol phosphate kinases (PIPKI)...
Rossella Venditti,Maria Chiara Masone,Cathal Wilson et al.
Rossella Venditti et al.
During recent decades, PI(4)P (phosphoinositol-4-phosphate) has been described as a key regulator of a wide range of cellular functions such as organelle biogenesis, lipid metabolism and distribution, membrane trafficking, ion channels, pum...
CHK1 and replicative stress in T-cell leukemia: Can an irreverent tumor suppressor end up playing the oncogene? [0.03%]
CHK1和T细胞白血病中的复制压力：一个不负责任的抑癌基因最终会成为原癌基因吗？
Leonor M Sarmento,João T Barata
Leonor M Sarmento
Replicative stress (RS) is a cell-intrinsic phenomenon enhanced by oncogenic transformation. Checkpoint kinase 1 (CHK1) is a key component of the ATR-dependent DNA damage response pathway that protects cells from RS by preventing replicatio...
Novel roles of androgen receptor, epidermal growth factor receptor, TP53, regulatory RNAs, NF-kappa-B, chromosomal translocations, neutrophil associated gelatinase, and matrix metalloproteinase-9 in prostate cancer and prostate cancer stem cells [0.03%]
雄激素受体、表皮生长因子受体、TP53、调控性RNA、NF-kappa-B、染色体易位、中性粒细胞相关胶原酶和基质金属蛋白酶-9在前列腺癌及前列腺癌干细胞中的新作用
William H Chappell,Stephen L Abrams,Kvin Lertpiriyapong et al.
William H Chappell et al.
Approximately one in six men will be diagnosed with some form of prostate cancer in their lifetime. Over 250,000 men worldwide die annually due to complications from prostate cancer. While advancements in prostate cancer screening and thera...
Lucio Cocco,Lucia Manzoli,Irene Faenza et al.
Lucio Cocco et al.
PI-PLCbeta1 plays an important role in cell differentiation, and particularly in myogenesis, osteogenesis and hematopoiesis. Indeed, the increase of PI-PLCbeta1, along with Cyclin D3, has been detected in C2C12 mouse myoblasts induced to di...
Reciprocal regulation of p53 and NF-κB by diacylglycerol kinase ζ [0.03%]
DGKζ通过调节p53和NF-κB从而抑制炎症及肿瘤促进表型的转换
Toshiaki Tanaka,Rieko Tsuchiya,Yasukazu Hozumi et al.
Toshiaki Tanaka et al.
Diacylglycerol kinase (DGK) participates in lipid mediated-signal transduction. It phosphorylates diacylglycerol (DG) to phosphatidic acid (PA), thereby regulating the balanced control of these second messenger actions. Previous reports hav...
Why always lysine? The ongoing tale of one of the most modified amino acids [0.03%]
为什么总是赖氨酸？最常被修饰的氨基酸之一的故事仍在继续
Cristina Azevedo,Adolfo Saiardi
Cristina Azevedo
The complex physiology of living organisms must be finely-tuned to permit the flexibility required to respond to the changing environment. Evolution has provided an interconnected and intricate array of regulatory mechanisms to facilitate t...
Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1 [0.03%]
时间分辨的FRET报告FGFR1二聚化及其与效应物PLCγ1形成复合物的情况
Louis Perdios,Tom D Bunney,Sean C Warren et al.
Louis Perdios et al.
In vitro and in vivo imaging of protein tyrosine kinase activity requires minimally invasive, molecularly precise optical probes to provide spatiotemporal mechanistic information of dimerization and complex formation with downstream effecto...