Phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ), a lipid signalling enigma [0.03%]
磷脂酰肌醇5-磷酸4-激酶γ（PI5P4Kγ），一种脂质信号传导谜题
Maria-Luisa Giudici,Jonathan H Clarke,Robin F Irvine
Maria-Luisa Giudici
The phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are an important family of enzymes, whose physiological roles are being teased out by a variety of means. Phosphatidylinositol-5-phosphate 4-kinase γ (PI5P4Kγ) is especially intrigu...
Phospholipase C zeta (PLCζ) and male infertility: Clinical update and topical developments [0.03%]
磷脂酶C扎塔(PLCζ)与男性不育：临床更新和专题进展
Siti Nornadhirah Amdani,Marc Yeste,Celine Jones et al.
Siti Nornadhirah Amdani et al.
The development of a mammalian embryo is initiated by a sequence of molecular events collectively referred to as 'oocyte activation' and regulated by the release of intracellular calcium in the ooplasm. Over the last decade, phospholipase C...
Accumulating insights into the role of phospholipase D2 in human diseases [0.03%]
关于磷脂酶D2在人类疾病中作用的见解积累
Jaewang Ghim,Chaithanya Chelakkot,Yoe-Sik Bae et al.
Jaewang Ghim et al.
Phospholipase D2 (PLD2) is a lipid-signaling enzyme that produces the signaling molecule phosphatidic acid (PA) by catalyzing the hydrolysis of phosphatidylcholine (PC). The molecular characteristics of PLD2, the mechanisms of regulation of...
Eunha Kim,Jiyoon Beon,Seulgi Lee et al.
Eunha Kim et al.
Inositol-derived metabolites (e.g., phosphoinositides and inositol polyphosphates) are key second messengers that are essential for controlling a wide range of cellular events. Inositol polyphosphate multikinase (IPMK) exhibits complex cata...
Phospholipase C δ1 in macrophages negatively regulates TLR4-induced proinflammatory cytokine production and Fcγ receptor-mediated phagocytosis [0.03%]
磷脂酶Cδ1通过负调控巨噬细胞中TLR4诱导的促炎症因子产生和Fcγ受体介导的吞噬作用发挥抑癌作用
Kohya Kudo,Takafumi Uchida,Mayu Sawada et al.
Kohya Kudo et al.
Macrophages are key players in the innate immune response. Turnover of phosphoinositides (PI), particularly phosphatidylinositol 4,5 bisphosphate (PI(4,5)P2), has been implicated in macrophage functions such as toll-like receptor (TLR)-medi...
Investigating the effect of arachidonate supplementation on the phosphoinositide content of MCF10a breast epithelial cells [0.03%]
花生四烯酸补充对乳腺上皮细胞MCF10a磷脂肌醇含量的影响研究
Karen E Anderson,Veronique Juvin,Jonathan Clark et al.
Karen E Anderson et al.
Phosphoinositides in primary mammalian tissue are highly enriched in a stearoyl/arachidonyl (C38:4) diacylgycerol backbone. However, mammalian cells grown in culture typically contain more diverse molecular species of phosphoinositides, cha...
Yong Ryoul Yang,Du-Seock Kang,Cheol Lee et al.
Yong Ryoul Yang et al.
In the brain, the primary phospholipase C (PLC) proteins, PLCβ, and PLCγ, are activated primarily by neurotransmitters, neurotrophic factors, and hormones through G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). A...
Melissa Maczis,Sheldon Milstien,Sarah Spiegel
Melissa Maczis
Breast cancer remains the most common malignant disease in women. The estrogen receptor-α (ERα) and its ligand 17β-estradiol (E2) play important roles in breast cancer. E2 elicits cellular effects by binding to ERα in the cytosol follow...
Laura Norton,Yvonne Lindsay,Arnaud Deladeriere et al.
Laura Norton et al.
Class I phosphoinositide 3-kinases (PI3Ks) are important regulators of neutrophil migration in response to a range of chemoattractants. Their primary lipid products PtdIns(3,4,5)P3 and PtdIns(3,4)P2 preferentially accumulate near to the lea...
Roles of phosphoinositide-specific phospholipase Cγ1 in brain development [0.03%]
磷脂酶Cγ1在脑发育中的作用研究进展
Du-Seock Kang,Yong Ryoul Yang,Cheol Lee et al.
Du-Seock Kang et al.
Over the past decade, converging evidence suggests that PLCγ1 signaling has key roles in controlling neural development steps. PLCγ1 functions as a signal transducer that converts an extracellular stimulus into intracellular signals by ge...