The AP-4 accessory protein tepsin exhibits multivalent binding to LC3B [0.03%]
AP-4 附属蛋白 tepsin 可与 LC3B 多价结合
Cameron I Cohen,Amy K Kendall,Natalie S Wallace et al.
Cameron I Cohen et al.
Tepsin is an accessory protein in Adaptor Protein 4 (AP-4) coated vesicles responsible for trafficking cargo from the trans-Golgi network (TGN). AP-4 vesicles recognize and sort multiple cargoes including ATG9A, a lipid scramblase essential...
PKCα as a signaling gatekeeper upstream of mTORC1 in mEGFR NSCLC [0.03%]
mEGFR NSCLC中PKCα作为mTORC1上游的信号守门员
Mojtaba Sadeghi,Sam B Chiappone,Mohamed F Salama et al.
Mojtaba Sadeghi et al.
Despite decades of research since phorbol esters first linked protein kinase C (PKC) to tumor promotion, the biological role of this family of kinases in cancer has remained ambiguous because of isozyme-specific functions and tissue-type-de...
Phosphatidic acid at the crossroads of membrane dynamics: from molecular specificity to synthetic innovation [0.03%]
磷脂酸在膜动态的十字路口：从中分子特异性到合成创新
Alexander Wolf,Emeline Tanguy,Stéphane Gasman et al.
Alexander Wolf et al.
Phosphatidic acid (PA) has emerged as a central regulator of membrane dynamics, vesicle trafficking, exocytosis, and intracellular signaling. Building on recent advances, including subspecies-specific functions of PA in neuroendocrine exocy...
Computational docking of sphingolipids into the regulatory binding site of serine palmitoyltransferase [0.03%]
鞘脂分子与丝氨酸棕榈酰转移酶调节结合位点的计算对接研究
Matthew Peart,Balaji Nagarajan,Glen E Kellogg et al.
Matthew Peart et al.
Canonically known both for structural contributions to lipid bilayers and roles in cell signaling, the sphingolipids comprise a dynamic, multifaceted class of molecules which are studied to understand cell biology and pathophysiology. All s...
Chiara Giannini,Luca Ponzone,Nicola Barroero et al.
Chiara Giannini et al.
The Endosomal Sorting Complex Required for Transport (ESCRT) machinery orchestrates a wide range of membrane remodeling and repair events, spanning multivesicular body biogenesis, viral budding, nuclear envelope surveillance, cytokinesis, l...
Toshiaki Tanaka,Mitsuyoshi Iino,Kaoru Goto
Toshiaki Tanaka
DNA double-strand breakage is the most lethal damage to chromosomal DNA. It activates a series of cellular DNA damage response pathways, including DNA damage sensing, control of cell cycle arrest and apoptosis, and DNA repair. DNA damage re...
Fiddia Zahra,Natasha E Zachara
Fiddia Zahra
The modification of nuclear, cytoplasmic, and mitochondrial proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) has emerged as an essential post-translational modification in mammals. More than 5000 human proteins are subject to O-GlcNAc...
Alpha-to-beta cell crosstalk: Adaptive mechanisms shaping islet function [0.03%]
从 alpha 细胞到 beta 细胞的信号串通：调节胰岛功能的适应性机制
Philip Tröster,Montse Visa,Per-Olof Berggren
Philip Tröster
The pancreatic islet, historically described as a binary system of insulin-secreting beta cells and glucagon-secreting alpha cells, is increasingly recognized as a complex paracrine network contributing to glucose homeostasis. Alpha-to-beta...
Induced pluripotent stem cell-based modelling of disease evolution in myeloid leukemia: MDS to AML [0.03%]
基于诱导多能干细胞的骨髓白血病疾病演变建模：MDS到AML
Jacqueline Boultwood
Jacqueline Boultwood
The myelodysplastic syndromes (MDS) are common myeloid malignancies that develop from the successive acquisition of driver mutations in hematopoietic stem cells residing in the bone marrow. Around a third of MDS patients will develop second...
CD19 structure, expression, and signaling: From basic mechanisms to therapeutic targeting [0.03%]
CD19结构、表达和信号转导：从基本机制到治疗靶向
Stéphane Schurmans,Bastien Moës
Stéphane Schurmans
CD19 is a central regulator of B-cell biology, acting both as a lineage marker and a critical modulator of signaling thresholds that govern development, activation, and tolerance. Structurally, CD19 is a heavily glycosylated transmembrane p...