Computational docking of sphingolipids into the regulatory binding site of serine palmitoyltransferase [0.03%]
鞘脂分子与丝氨酸棕榈酰转移酶调节结合位点的计算对接研究
Matthew Peart,Balaji Nagarajan,Glen E Kellogg et al.
Matthew Peart et al.
Canonically known both for structural contributions to lipid bilayers and roles in cell signaling, the sphingolipids comprise a dynamic, multifaceted class of molecules which are studied to understand cell biology and pathophysiology. All s...
Chiara Giannini,Luca Ponzone,Nicola Barroero et al.
Chiara Giannini et al.
The Endosomal Sorting Complex Required for Transport (ESCRT) machinery orchestrates a wide range of membrane remodeling and repair events, spanning multivesicular body biogenesis, viral budding, nuclear envelope surveillance, cytokinesis, l...
Toshiaki Tanaka,Mitsuyoshi Iino,Kaoru Goto
Toshiaki Tanaka
DNA double-strand breakage is the most lethal damage to chromosomal DNA. It activates a series of cellular DNA damage response pathways, including DNA damage sensing, control of cell cycle arrest and apoptosis, and DNA repair. DNA damage re...
Fiddia Zahra,Natasha E Zachara
Fiddia Zahra
The modification of nuclear, cytoplasmic, and mitochondrial proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) has emerged as an essential post-translational modification in mammals. More than 5000 human proteins are subject to O-GlcNAc...
Alpha-to-beta cell crosstalk: Adaptive mechanisms shaping islet function [0.03%]
从 alpha 细胞到 beta 细胞的信号串通：调节胰岛功能的适应性机制
Philip Tröster,Montse Visa,Per-Olof Berggren
Philip Tröster
The pancreatic islet, historically described as a binary system of insulin-secreting beta cells and glucagon-secreting alpha cells, is increasingly recognized as a complex paracrine network contributing to glucose homeostasis. Alpha-to-beta...
Induced pluripotent stem cell-based modelling of disease evolution in myeloid leukemia: MDS to AML [0.03%]
基于诱导多能干细胞的骨髓白血病疾病演变建模：MDS到AML
Jacqueline Boultwood
Jacqueline Boultwood
The myelodysplastic syndromes (MDS) are common myeloid malignancies that develop from the successive acquisition of driver mutations in hematopoietic stem cells residing in the bone marrow. Around a third of MDS patients will develop second...
CD19 structure, expression, and signaling: From basic mechanisms to therapeutic targeting [0.03%]
CD19结构、表达和信号转导：从基本机制到治疗靶向
Stéphane Schurmans,Bastien Moës
Stéphane Schurmans
CD19 is a central regulator of B-cell biology, acting both as a lineage marker and a critical modulator of signaling thresholds that govern development, activation, and tolerance. Structurally, CD19 is a heavily glycosylated transmembrane p...
Marvellous Oyeyode,Mathew Tempel,Ted M Lakowski et al.
Marvellous Oyeyode et al.
DNA-intercalating drugs (e.g., doxorubicin) have been used in cancer treatment since the 1960s. Multiple mechanisms have been observed with these drugs. These drugs intercalate into nucleosome-free regions of chromatin, which play a crucial...
Conventional and alternative approaches for targeting PIK3CA and PTEN alterations in head and neck, breast, and other cancers [0.03%]
靶向PIK3CA和PTEN改变的常规方法和替代方法在头颈、乳腺和其他癌症中的应用
Jovanka Gencel-Augusto,Jennifer R Grandis,Daniel E Johnson
Jovanka Gencel-Augusto
Genetic alterations in genes encoding components of the PI3K/AKT/mTOR signaling pathway are frequently observed in head and neck squamous cell carcinoma (HNSCC), breast cancer, and a variety of other human malignancies. In particular, PIK3C...
Continuous fractionated irradiation with irradiation-free intervals enhances survival and clonogenicity in osteosarcoma MG-63 cells via adaptive DNA damage response [0.03%]
持续照射结合无照射间歇通过适应性DNA损伤反应增强成骨肉瘤MG-63细胞的存活和集落形成能力
Hiroko Ikeda,Yuka Amano,Koki Hara et al.
Hiroko Ikeda et al.
Radiotherapy is a widely used treatment modality for various types of cancer. However, the adaptive resistance of tumor cells during radiotherapy poses a major challenge to therapeutic efficacy. This study aimed to evaluate whether continuo...