Lucio Cocco
Lucio Cocco
Qianqian Ma,Lakshmi Srinivasan,Sandra B Gabelli et al.
Qianqian Ma et al.
Mammalian diacylglycerol kinases (DGKs) are a group of enzymes that catalyze the ATP-dependent phosphorylation of diacylglycerol (DAG) to produce phosphatidic acid (PtdOH). In doing so, they modulate the levels of these two important signal...
Andrea Papdiné Morovicz,Fatemeh Mazloumi Gavgani,Rhîan G Jacobsen et al.
Andrea Papdiné Morovicz et al.
The phosphoinositide 3-kinase (PI3K) signalling pathway plays key roles in many cellular processes and is altered in many diseases. The function and mode of action of the pathway have mostly been elucidated in the cytoplasm. However, many o...
Bisphosphate nucleotidase 2 (BPNT2), a molecular target of lithium, regulates chondroitin sulfation patterns in the cerebral cortex and hippocampus [0.03%]
双磷酸核苷酸酶2（BPNT2）是锂的一个分子靶点，可调节大脑皮层和海马体中的硫酸软骨素模式
Brynna S Eisele,Alice J Wu,Zigmund Luka et al.
Brynna S Eisele et al.
Bisphosphate nucleotidase 2 (BPNT2) is a member of a family of phosphatases that are directly inhibited by lithium, the first-line medication for bipolar disorder. BPNT2 is localized to the Golgi, where it metabolizes the by-products of gly...
Extracellular vesicles derived from pancreatic cancer cells are enriched in the growth factor Midkine [0.03%]
来源于胰腺癌细胞的细胞外囊泡富含生长因子中肾素
Ilaria Casari,Aikaterini Emmanouilidi,Alice Domenichini et al.
Ilaria Casari et al.
The growth factor Midkine is a heparin-binding cytokine originally discovered during the differentiation process induced by the retinoic acid in embryonal carcinoma cells. Several studies pointed out the key role of this protein in tumour p...
Phospholipase D1-generated phosphatidic acid modulates secretory granule trafficking from biogenesis to compensatory endocytosis in neuroendocrine cells [0.03%]
磷脂酶D1生成的磷脂酸在神经内分泌细胞中从生物合成到补偿性胞吞作用的过程中调节分泌颗粒转运
Emeline Tanguy,Alexander Wolf,Qili Wang et al.
Emeline Tanguy et al.
Calcium-regulated exocytosis is a multi-step process that allows specialized secretory cells to release informative molecules such as neurotransmitters, neuropeptides, and hormones for intercellular communication. The biogenesis of secretor...
Rapid testing of candidate oncogenes and tumour suppressor genes in signal transduction and neoplastic transformation [0.03%]
候选癌基因和肿瘤抑制基因在信号转导和恶变中的快速检测
Sha Liu,Paula Medina-Perez,Minh-Cam Ha-Thi et al.
Sha Liu et al.
The COSMIC database (version 94) lists 576 genes in the Cancer Gene Census which have a defined function as drivers of malignancy (oncogenes) or as tumour suppressors (Tier 1). In addition, there are 147 genes with similar functions, but wh...