Why COVID-19 modelling of progression and prevention fails to translate to the real-world [0.03%]
为何新冠肺炎疫情的进展和预防建模无法转化为现实世界措施
Carl J Heneghan,Tom Jefferson
Carl J Heneghan
Mathematical models were used widely to inform policy during the COVID pandemic. However, there is a poor understanding of their limitations and how they influence decision-making. We used systematic review search methods to find early mode...
Phosphoregulation of the ATP synthase beta subunit stimulates mitochondrial activity for G2/M progression [0.03%]
ATP合成酶β亚基的磷蛋白调节可刺激线粒体活性以促进G2/M期进程
Ana Cláudia Leite,Telma Silva Martins,Ana Campos et al.
Ana Cláudia Leite et al.
Mitochondrial ATP synthase is a multifunctional enzyme complex involved in ATP production. We previously reported that the ATP synthase catalytic beta subunit (Atp2p in yeast) is regulated by the 2A-like protein phosphatase Sit4p, which tar...
Gaining insight into the role of FoxO1 in the progression of disuse-induced skeletal muscle atrophy [0.03%]
FoxO1在失用性肌肉萎缩发生发展中的作用及机制研究新进展
Natalia Vilchinskaya,Erzhena Altaeva,Yulia Lomonosova
Natalia Vilchinskaya
Expression of FoxO transcription factors increases during certain forms of atrophy. In a dephosphorylated state, FoxOs participate in ubiquitin-mediated proteasomal degradation through the transcriptional activation of E3-ubiquitin ligases ...
Establishing COVID-19 trials at scale and pace: Experience from the RECOVERY trial [0.03%]
RECOVERY试验的大规模和快速建立新冠肺炎临床试验的经验
Leon Peto,Peter Horby,Martin Landray
Leon Peto
The Randomised Evaluation of COVID-19 Therapy (RECOVERY) Trial was set up in March 2020 to evaluate treatments for people hospitalised with COVID-19. To maximise recruitment it was designed to fit into routine clinical care throughout the U...
Sphingolipids and their role in health and disease in the central nervous system [0.03%]
鞘脂和它们在中枢神经系统健康与疾病中的作用
Andrés Felipe Leal,Diego A Suarez,Olga Yaneth Echeverri-Peña et al.
Andrés Felipe Leal et al.
Sphingolipids (SLs) are lipids derived from sphingosine, and their metabolism involves a broad and complex network of reactions. Although SLs are widely distributed in the body, it is well known that they are present in high concentrations ...
Nicole M Carter,Joel L Pomerantz
Nicole M Carter
Regulatory T cells (Tregs) are a critical subset of CD4 T cells that modulate the immune response to prevent autoimmunity and chronic inflammation. CARD11, a signaling hub and scaffold protein that links antigen receptor engagement to activ...
New strategies for combating fungal infections: Inhibiting inositol lipid signaling by targeting Sec14 phosphatidylinositol transfer proteins [0.03%]
防治真菌感染的新策略——靶向Sec14磷脂酰肌醇转移蛋白抑制肌醇脂信号转导
Vytas A Bankaitis,Ashutosh Tripathi,Xiao-Ru Chen et al.
Vytas A Bankaitis et al.
Virulent fungi represent a particularly difficult problem in the infectious disease arena as these organisms are eukaryotes that share many orthologous activities with their human hosts. The fact that these activities are often catalyzed by...
Phosphorylation-mediated regulation of the Nem1-Spo7/Pah1 phosphatase cascade in yeast lipid synthesis [0.03%]
酵母脂质合成中Nem1-Spo7/Pah1磷酸酶级联反应的磷酸化调节机制研究
Shoily Khondker,Gil-Soo Han,George M Carman
Shoily Khondker
The PAH1-encoded phosphatidate phosphatase, which catalyzes the dephosphorylation of phosphatidate to produce diacylglycerol, controls the divergence of phosphatidate into triacylglycerol synthesis and phospholipid synthesis. Pah1 is inacti...
CCAAT enhancer binding protein gamma (C/EBP-γ): An understudied transcription factor [0.03%]
CCAAT增强子结合蛋白伽马(C/EBP-γ)：一种鲜少被研究的转录因子
Zachary Renfro,Bryan E White,Kimberly E Stephens
Zachary Renfro
The CCAAT enhancer binding protein (C/EBP) family of transcription factors are important transcriptional mediators of a wide range of physiologic processes. C/EBP-γ is the shortest C/EBP protein and lacks a canonical activation domain for ...
Disentangling the signaling pathways of mTOR complexes, mTORC1 and mTORC2, as a therapeutic target in glioblastoma [0.03%]
解开mTOR复合物（mTORC1和mTORC2）信号通路作为胶质母细胞瘤治疗靶点的研究
Meena Jhanwar-Uniyal,Jose F Dominguez,Avinash L Mohan et al.
Meena Jhanwar-Uniyal et al.
Aberrant signaling of mechanistic target of rapamycin (mTOR aka mammalian target of rapamycin) is shown to be linked to tumorigenesis of numerous malignancies including glioblastoma (GB). mTOR is a serine threonine kinase that functions by ...