Understanding the exceptional pre-vaccination Era East Asian COVID-19 outcomes [0.03%]
了解东亚地区新冠疫苗接种前的异常优秀成果
Jay Bhattacharya,Phillip Magness,Martin Kulldorff
Jay Bhattacharya
During the first year of the pandemic, East Asian countries have reported fewer infections, hospitalizations, and deaths from COVID-19 disease than most countries in Europe and the Americas. Our goal in this paper is to generate and evaluat...
Structural investigation of eukaryotic cells: From the periphery to the interior by cryo-electron tomography [0.03%]
冰冻电子断层扫描技术在真核细胞结构研究中的应用：从表面到内部
Chunyang Wang,Matthias Wojtynek,Ohad Medalia
Chunyang Wang
Cryo-electron tomography (cryo-ET) combines a close-to-life preservation of the cell with high-resolution three-dimensional (3D) imaging. This allows to study the molecular architecture of the cellular landscape and provides unprecedented v...
Alexander Wolf,Emeline Tanguy,Qili Wang et al.
Alexander Wolf et al.
In mammals, phospholipase D (PLD) enzymes involve 6 isoforms, of which only three have established lipase activity to produce the signaling lipid phosphatidic acid (PA). This phospholipase activity has been postulated to contribute to cance...
Regulations of myo-inositol homeostasis: Mechanisms, implications, and perspectives [0.03%]
肌醇稳态的调控机制、意义及展望
Xue Bessie Su,An-Li Andrea Ko,Adolfo Saiardi
Xue Bessie Su
Phosphorylation is the most common module of cellular signalling pathways. The dynamic nature of phosphorylation, which is conferred by the balancing acts of kinases and phosphatases, allows this modification to finely control crucial cellu...
Novel aspects of intra-islet communication: Primary cilia and filopodia [0.03%]
胰岛内全新细胞间通讯方式：初级纤毛和丝状足
Noah Moruzzi,Barbara Leibiger,Christopher J Barker et al.
Noah Moruzzi et al.
Pancreatic islets are micro-organs composed of a mixture of endocrine and non-endocrine cells, where the former secrete hormones and peptides necessary for metabolic homeostasis. Through vasculature and innervation the cells within the isle...
Effects of chloroquine and hydroxychloroquine on the sensitivity of pancreatic cancer cells to targeted therapies [0.03%]
氯喹和羟氯喹对胰腺癌细胞靶向治疗敏感性的影响
James A McCubrey,Stephen L Abrams,Matilde Y Follo et al.
James A McCubrey et al.
Approaches to improve pancreatic cancer therapy are essential as this disease has a very bleak outcome. Approximately 80% of pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC). PDAC is a cancer which is difficult to effectively...
John P A Ioannidis,Stephen H Powis
John P A Ioannidis
Virus spread on a scale-free network reproduces the Gompertz growth observed in isolated COVID-19 outbreaks [0.03%]
无尺度网络上的病毒传播再现了孤立的COVID-19疫情中的戈莫普兹增长现象
Francesco Zonta,Michael Levitt
Francesco Zonta
The counts of confirmed cases and deaths in isolated SARS-CoV-2 outbreaks follow the Gompertz growth function for locations of very different sizes. This lack of dependence on region size leads us to hypothesize that virus spread depends on...
Splicing factor mutations in the myelodysplastic syndromes: Role of key aberrantly spliced genes in disease pathophysiology and treatment [0.03%]
髓系肿瘤中剪接因子的突变及其异常剪接基因在疾病发生发展和治疗中的作用
Andrea Pellagatti,Jacqueline Boultwood
Andrea Pellagatti
Mutations of splicing factor genes (including SF3B1, SRSF2, U2AF1 and ZRSR2) occur in more than half of all patients with myelodysplastic syndromes (MDS), a heterogeneous group of myeloid neoplasms. Splicing factor mutations lead to aberran...
A consensus of evidence: The role of SPI-M-O in the UK COVID-19 response [0.03%]
证据共识：SPI-M-O在英国新冠肺炎疫情应对中的作用
Graham F Medley
Graham F Medley