Freeze-induced suppression of pyruvate kinase in liver of the wood frog (Rana sylvatica) [0.03%]
木蛙(Rana sylvatica)肝脏中丙酮酸激酶的冻融抑制作用
Anchal Varma,Kenneth B Storey
Anchal Varma
The wood frog (Rana sylvatica) undergoes physiological and metabolic changes to withstand subzero temperatures and whole body freezing during the winter months. Along with metabolic rate depression, high concentrations of glucose are produc...
DJ-1 promotes cell migration by interacting with Mena, the mammalian homolog of Drosophila enabled [0.03%]
DJ-1通过与哺乳动物同源物Mena相互作用来促进细胞迁移，Mena是果蝇enabled的哺乳动物同源物
Sanguk Yun,Sun-Shin Cha,Jae Ho Kim
Sanguk Yun
DJ-1 has gained extensive attention after being identified in 2003 as a protein implicated in the pathogenesis of early-onset Parkinson's disease. Since then, efforts have revealed versatile DJ-1 functions in reactive oxygen species (ROS) c...
PIP kinases: A versatile family that demands further therapeutic attention [0.03%]
PIP激酶：一个需要进一步治疗关注的多功能家族
Alicia Llorente,Gurpreet K Arora,Shea F Grenier et al.
Alicia Llorente et al.
Phosphoinositides are membrane-localized phospholipids that regulate a plethora of essential cellular processes. These lipid signaling molecules are critical for cell homeostasis and therefore their levels are strictly regulated by the coor...
From form to function: m6A methylation links mRNA structure to metabolism [0.03%]
从形式到功能：m6A甲基化连接mRNA结构和代谢
Braulio Martinez De La Cruz,Marousa Darsinou,Antonella Riccio
Braulio Martinez De La Cruz
Reversible N6-methyladenosine (m6A) RNA modification is a posttranscriptional epigenetic modification of the RNA that regulates many key aspects of RNA metabolism and function. In this review, we highlight major recent advances in the field...
Christine Sers,Reinhold Schäfer
Christine Sers
Mutated genes of the RAS family encoding small GTP-binding proteins drive numerous cancers, including pancreatic, colon and lung tumors. Besides the numerous effects of mutant RAS gene expression on aberrant proliferation, transformed pheno...
Phosphorylation of DGK [0.03%]
DGK的磷酸化
Xin Barbernitz,Daniel M Raben
Xin Barbernitz
Diacylglycerol (DAG) and phosphatidic acid (PtdOH) play important roles in a variety of signaling cascades (Carrasco and Merida, 2007; Stace and Ktistakis, 2006). Therefore, the physiological roles and regulatory mechanisms controlling the ...
IL-7 and IL-7R in health and disease: An update through COVID times [0.03%]
健康与疾病中的白细胞介素-7和白细胞介素-7受体：新冠疫情下的更新报告
Marta B Fernandes,João T Barata
Marta B Fernandes
The role of IL-7 and IL-7R for normal lymphoid development and an adequately functioning immune system has been recognized for long, with severe immune deficiency and lymphoid leukemia as extreme examples of the consequences of deregulation...
Regulation of eukaryotic protein kinases by Pin1, a peptidyl-prolyl isomerase [0.03%]
肽基脯氨酰异构酶Pin1对真核蛋白激酶的调控作用
Xiao-Ru Chen,Tatyana I Igumenova
Xiao-Ru Chen
The peptidyl-prolyl isomerase Pin1 cooperates with proline-directed kinases and phosphatases to regulate multiple oncogenic pathways. Pin1 specifically recognizes phosphorylated Ser/Thr-Pro motifs in proteins and catalyzes their cis-trans i...
Modified lipidomic profile of cancer-associated small extracellular vesicles facilitates tumorigenic behaviours and contributes to disease progression [0.03%]
癌症相关的小细胞外囊泡的脂质组谱发生变化促进肿瘤行为并推动疾病进展
Jordan Fyfe,Pratibha Malhotra,Marco Falasca
Jordan Fyfe
Metabolic rewiring is a key feature of cancer cells, which involves the alteration of amino acids, glucose and lipids to support aggressive cancer phenotypes. Changes in lipid metabolism alter cancer growth characteristics, membrane integri...
The mutational profiles and corresponding therapeutic implications of PI3K mutations in cancer [0.03%]
PI3K基因突变在癌症中的突变谱及相应的治疗意义
Nathan K VanLandingham,Andrew Nazarenko,Jennifer R Grandis et al.
Nathan K VanLandingham et al.
Genetic alterations of the PIK3CA gene, encoding the p110α catalytic subunit of PI3Kα enzyme, are found in a broad spectrum of human cancers. Many cancer-associated PIK3CA mutations occur at 3 hotspot locations and are termed canonical mu...