A Metastasis-Competent CAF Subpopulation Defined by MFAP5⁷THY1⁷ Co-expression Drives Prostate Cancer Metastasis via EMT Activation [0.03%]
MFAP5⁺THY1⁺表达的肿瘤相关成纤维细胞驱动前列腺癌转移发生
Yongqiang Huang,Yu Wang,Wei Zhang et al.
Yongqiang Huang et al.
Background: The tumor microenvironment, particularly cancer-associated fibroblasts (CAFs), contributes to prostate cancer (PCa) metastasis, however, the role of CAF heterogeneity remains incompletely characterized. The st...
Zhe-Sheng Jason Chen,Bohan Zhang
Zhe-Sheng Jason Chen
Tracing the Technological Trajectory of CAR-T Cell Therapy in Cancer Treatment through Patent Analysis [0.03%]
基于专利分析追踪CAR-T细胞治疗癌症的技术路线变迁
Yilan Guan,Yunting Liu,Yuxuan Sun et al.
Yilan Guan et al.
Introduction: CAR-T technology represents a state-of-the-art approach in cancer treatment. This study constructs a multi-dimensional framework for analyzing the technological trajectory to comprehensively clarify the evol...
CAD is Associated with Cancer Prognosis and Promotes Enzalutamide Resistance in Prostate Cancer [0.03%]
CAD与癌症预后相关并促进前列腺癌恩杂鲁胺耐药性
Bing-Xue Ma,Yi-You Mao,Ze-Fan Zhang et al.
Bing-Xue Ma et al.
Introduction: Preliminary investigations into the feasibility of Carbamoyl-phosphate synthetase 2, Aspartate transcarbamoylase, and Dihydroorotase (CAD)-targeted therapies have been conducted in a limited range of cancer ...
Mendelian Randomization Combined with Experimental Validation Identifies Prognostic Genes LMNB1 and PLXNB2 in the Immune Response in Multiple Myeloma [0.03%]
结合实验验证的孟德尔随机化在多发性骨髓瘤免疫反应中鉴定LMNB1和PLXNB2为预后基因
Xiaofen Zhang,Qiuhong Kong,Jianhao Zhao et al.
Xiaofen Zhang et al.
Introduction: Immune regulatory genes, such as PLXNB2, play critical roles in the tumor microenvironment, yet their specific functions in Multiple Myeloma [MM] remain largely unclear. ...
Aucubin Inhibits Liver Cancer via HMGB1-mediated Inactivation of the PI3K/AKT/mTOR Signaling Pathway [0.03%]
aucubin通过HMGB1介导的PI3K/AKT/mTOR信号通路失活抑制肝癌
Weinan Li,Xuan Ma,Yong Mei et al.
Weinan Li et al.
Introduction: Liver cancer remains one of the most aggressive and lethal malignancies worldwide，and current therapeutic efforts show limited survival benefits. Based on our previous findings that aucubin attenuates liver i...
Advances in Artemisinin-based Therapies: Innovations in Synthesis, Drug Delivery, and Expanding Therapeutic Applications [0.03%]
基于青蒿素治疗的进展：合成、药物输送及扩展治疗应用的创新
Akshay Thakur,Gaurav Thakur,Vir Vikram Sharma et al.
Akshay Thakur et al.
Artemisinin, a natural compound derived from Artemisia annua, has significantly impacted the treatment of malaria and has shown promise in various other therapeutic applications. This review explores the molecular structure of artemisinin a...
Diosgenin-loaded Silver Nanoparticles: Dual Protective Role and Enhanced Radiosensitivity against ENU-induced Leukemia and γ-irradiation-induced Liver Toxicity [0.03%]
薯蓣皂苷元载银纳米颗粒对ENU诱导的白血病和γ射线诱导的肝毒性损伤的双重保护作用及增敏效应研究
Amira Atef Mahmoud,Mohammed A Hussein,Ahmed M Hamdy et al.
Amira Atef Mahmoud et al.
Introduction: Leukemia and radiation-induced liver toxicity are significant health challenges requiring effective therapeutic strategies. This study aimed to evaluate the therapeutic efficacy and radiosensitizing effects ...
Nano-carriers based Approaches Loaded with Herbal Bioactive Compounds for the Treatment of Cancer: Recent Updates and Future Prospects [0.03%]
载有植物药生物活性成分的纳米载体在癌症治疗中的最新研究进展及未来前景
Ameeduzzafar Zafar,Omar Awad Alsaidan,Md Ali Mujtaba
Ameeduzzafar Zafar
Introduction: Traditional cancer therapies like chemotherapy and radiotherapy frequently face challenges, such as systemic toxicity, the development of resistance, and poor tolerance among patients. Recently, there has be...
ABC Transporter Protein-mediated Multidrug Resistance in Breast Cancer and Development of Targeting Strategies [0.03%]
乳腺癌中由ABC转运蛋白介导的多药耐药及靶向策略的研发
Xiaoyun Yu,Qihang Shang,Mengrui Yang et al.
Xiaoyun Yu et al.
Drug resistance (MDR) poses a significant challenge in breast cancer (BrCa) treatment, resulting in reduced efficacy and increased tumor recurrence. Resolving MDR in BrCa is necessary for improving the clinical efficacy of antitumor therapy...