Qishen Yiqi Dripping Pills Combined with Exosomes Alleviate Myocardial I/R Injury by Regulating Macrophage Polarization via miRNA-155-5P [0.03%]
气肾益气滴丸联合外泌体通过miRNA-155-5P调节巨噬细胞极化减轻心肌缺血再灌注损伤
Weibin Qin,Weizhi Tang,Meng Wang et al.
Weibin Qin et al.
Introduction: To investigate the protective mechanism of Qishen Yiqi Dropping Pills (Qishen) and its key active ingredients in combination with exosomes from bone marrow mesenchymal stem cells (BMSCs) against myocardial i...
Promotion of Epithelial Healing in Oral Mucositis by hESC-derived Mesenchymal Stem Cells via the PI3K/AKT Pathway [0.03%]
人胚胎干细胞来源的间充质干细胞通过PI3K/AKT途径促进口腔黏膜炎上皮愈合
Kejia Lv,Bicong Gao,Weijia Ye et al.
Kejia Lv et al.
Introduction: Oral mucositis (OM) is a common and debilitating side effect of cancer therapies such as radiotherapy, chemotherapy, hematopoietic cell transplant, or their combinations. This study focused on the reparative...
Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Promote Ulcer Healing in Diabetes Mellitus Type 2 Mice [0.03%]
人脐带间充质干细胞来源的外泌体促进2型糖尿病小鼠溃疡愈合
Wenpo Feng,Chenxi Feng,Binbin Wang et al.
Wenpo Feng et al.
Background: With the passage of time, the incidence rate of diabetes continues to rise. As a common and serious complication of diabetes, the economic burden of diabetes ulcers is also increasing. However, there is curren...
The Acute Kidney Injury Induced by Cisplatin in Mice is Exacerbated by the Conditioned Medium Derived from the Cultivation of Mesenchymal Stem Cells under Hypoxic Conditions [0.03%]
缺氧条件下间充质干细胞培养上清液加重顺铂诱导的小鼠急性肾损伤
Andrey A Temnov,Alla N Sklifas,Mars G Sharapov et al.
Andrey A Temnov et al.
Background: Acute Kidney Injury (AKI) is a severe complication of cisplatin-based chemotherapy. Thus, searching for novel therapeutic approaches to reduce system toxicity is vital for improving patient outcomes. The use o...
Magnesium Regulates the Migration and Differentiation of NPMSCs via the Integrin Signaling Pathway [0.03%]
镁通过整合素信号通路调控NPMSCs的迁移及分化
Dong Yin,Chongquan Huang,Changxiang Liang et al.
Dong Yin et al.
Background: Nucleus pulposus mesenchymal stem cells play a fatal role in intervertebral disc homeostasis. Magnesium is an essential bioactive element for the human body, regulating intracellular enzyme activity and promot...
Salvianolic Acid B Accelerates Osteoporotic Fracture Healing via LncRNA-MALAT1/miR-155-5p/HIF1A Axis [0.03%]
天冬酸二乙酯通过LncRNA-MALAT1/miR-155-5p/HIF1A轴加速骨质疏松性骨折愈合
Zhao Gao,Ying Li,Yage Zhang et al.
Zhao Gao et al.
Background: Osteoporotic fracture is a pathological fracture secondary to osteoporosis, causing disabilities and a heavy burden to the patients. In the previous study, we found that salvianolic acid B (SalB) promoted the ...
A Study on the Role of miR-126 in the Repair Process after Spinal Cord Injury [0.03%]
miR-126在脊髓损伤修复过程的作用机制研究
Yaojun Suo,Chunfang Wang
Yaojun Suo
Background: Spinal Cord Injury (SCI) results in motor, sensory, and autonomic dysfunctions and causes social and economic problems. Surgery, medication, and stem cell transplantation are therapeutic strategies for SCI. Th...
Fulin Yuan,Qi Qi,Lei Wang et al.
Fulin Yuan et al.
Mesenchymal stem cells (MSCs) are adult stem cells with immunoregulatory abilities and low immunogenicity, exhibiting powerful immunosuppressive effects in various inflammatory diseases and holding promise for therapeutic applications. Howe...
TGF-β1 Induces Endoplasmic Reticulum Stress-dependent Apoptosis in Human Placental Mesenchymal Stem Cells of Fetal Origin through PERK Signaling Pathway [0.03%]
转化生长因子β1通过PERK信号通路诱导人胎儿源性胎盘间充质干细胞内质网应激依赖的凋亡
Yongzhao Zhu,Wei Xue,Juan Na et al.
Yongzhao Zhu et al.
Background: Mesenchymal Stem Cells (MSCs) are pivotal in immunomodulation, hematopoiesis, and tissue repair. The interplay between MSCs and the pathological microenvironment influences their proliferation and differentiat...
Human Amniotic Epithelial Stem Cells Activate Autophagy via the IL-6/STAT3/FOXO3a Pathway to Facilitate Liver Regeneration Following Hepatectomy [0.03%]
人胎盘羊膜上皮干细胞通过白细胞介素-6/信号转导子和转录激活子3/叉头框O3a途径促进手术切除肝脏的再生
Wenzhi Shu,Yisu Song,Zhengyang L Lu et al.
Wenzhi Shu et al.
Background and aim: Posthepatectomy liver failure leads to a poor prognosis in patients receiving hepatectomy treatment, and cell therapy can promote liver regeneration. In this study, we investigated the therapeutic pote...