Akshay Sankar Peethambaran,Neel Prabha,Prateek Pujar
Akshay Sankar Peethambaran
Background: Thalidomide has emerged as a novel antitumor drug with antiangiogenic and immunomodulatory properties. It was taken off the market in the early 1960s due to its infamous connection with congenital defects. Rec...
Prevalence and Impact of Antibodies Against TNF Alpha Inhibitors in Rheumatoid Arthritis and Spondyloarthritis: Systematic Review and Meta- Analysis with Subgroup Analysis [0.03%]
抗肿瘤坏死因子α制剂抗体在类风湿关节炎和脊柱关节炎中的流行病学及影响：系统评价和-meta分析及其亚组分析
Ines Mahmoud,Selma Bouden,Rim Charfi et al.
Ines Mahmoud et al.
Objectives: We aimed to estimate the global prevalence of anti-drug antibodies (ADAb), their impact on response, and associated factors in adults with rheumatoid arthritis (RA) and spondyloarthritis (SpA) treated by TNF a...
Meta-Analysis
Current drug safety. 2025 Jul 2. DOI:10.2174/0115748863354926250620200719 2025
Exploring Vericiguat in Heart Failure: Mechanistic Insights, Therapeutic Advantages, and Clinical Validation [0.03%]
探索心力衰竭治疗的新药Vericiguat：机制洞察、治疗优势和临床验证
Wen-Rui Hao,Chun-Han Cheng,Huan-Yuan Chen et al.
Wen-Rui Hao et al.
Vericiguat, a novel stimulator of soluble guanylate cyclase (sGC), marks a significant advancement in the management of heart failure with reduced ejection fraction (HFrEF). By enhancing the nitric oxide signaling pathway, it facilitates va...
Enhancing Pharmacovigilance in Pharmaceutical Companies: A Comparative Study of Electronic Reporting Before and After Implementation [0.03%]
制药公司药品不良反应监测的改进：实施电子报告前后的比较研究
Ghita Meknassi Salime,Nihal Bhirich,Abdelghani Asraoui et al.
Ghita Meknassi Salime et al.
Background: Since 2016, Moroccan pharmaceutical companies have been required to report adverse effects linked to their medicines. Initially, reports were submitted using the CIOMS form, sent by normal mail to le Centre An...
Adverse Drug Reaction Profile of Capecitabine-based Chemotherapy Regimen and its Predisposing Factors in Patients Attending a Tertiary Care Hospital in South India [0.03%]
卡培他滨化疗方案不良反应的临床特征及其影响因素分析——南印度一家三级医院的回顾性研究
Avishek Amar,Jayanthi Mathaiyan,Biswajit Dubashi
Avishek Amar
Background: Capecitabine, an important drug used for solid tumors involving the gastrointestinal tract, is known to be associated with many Adverse Drug Reactions (ADRs) leading to dose modification or discontinuation. ...
The Impact of Non-Steroidal Anti-Inflammatory Drugs on Gastrointestinal Bleeding: Review on Risk Scoring for Better Prediction [0.03%]
非甾体抗炎药导致胃肠出血的影响：综述评分以更好预测风险
Dwi Aris Agung Nugrahaningsih,- Mustofa,Woro Rukmi Pratiwi et al.
Dwi Aris Agung Nugrahaningsih et al.
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed for pain relief and inflammation management; however, they can lead to serious upper gastrointestinal (GI) issues, including ulcers, bleeding, and perforations. This rev...
DRESS Syndrome with Cold Agglutinins: An Unusual Immune Response to Anticonvulsants [0.03%]
药物致敏引起的冷凝集素病并DRESS综合征
Sumit Jaiswal,Sourabh Pathania,Gaurav Sharma et al.
Sumit Jaiswal et al.
Introduction: DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) is a rare adverse drug reaction characterized by cutaneous and systemic manifestations, with a mortality rate of up to 10%. In this study, we des...
Evaluating the Impact of SGLT-2 Inhibitors on Frailty in Older Adults: A Clinical Review [0.03%]
钠-葡萄糖协同转运蛋白-2抑制剂对老年人脆弱性影响的临床评价
Sulthan Al Rashid,Abinaya Vannapatti Gopalakrishnan,Naina Mohamed Pakkir Maideen et al.
Sulthan Al Rashid et al.
Background: Sodium-glucose cotransporter-2 (SGLT-2) inhibitors, including empagliflozin, canagliflozin, and dapagliflozin, have demonstrated significant cardiovascular and renal benefits in managing type 2 diabetes mellit...
Simran Kaur,Simran Yadav,Vishesh Sahu et al.
Simran Kaur et al.
Introduction/objective: Biosimilars, a class of biologic medications that are highly similar to reference biologics, have emerged as cost-effective alternatives to their expensive originator counterparts. Due to their com...
Afifa Akram,Radhakrishan Gaur,Indu SIngh et al.
Afifa Akram et al.
Objective: This review investigates the regulatory framework for dermocosmetic bioactive in functional skincare, focusing on products with both cosmetic and pharmaceutical characteristics. The global regulatory environmen...