In vivo Tissue Reaction Assessment of a Novel Polycaprolacton-based Endodontic Sealer in Rat Model [0.03%]
一种基于聚己内酯的新型根管密封剂在大鼠模型中的活体组织反应评估
Kamal Attari,Maryam Janani,Shahriar Shahi et al.
Kamal Attari et al.
Introduction: One of the most important materials needed for root canal therapy is a sealer. The aim of this study was to assess the tissue reaction of a new polycaprolactone-based root canal sealer in a rat model. ...
Fatigue Associated with Trastuzumab Deruxtecan in Solid Tumors: A Meta-Analysis and Pharmacovigilance Signal Detection Study [0.03%]
针对实体瘤的曲妥珠单抗德鲁替康相关疲乏： meta分析和药物警戒监测信号研究
Yinyin Ye,Yuyao Tang,Yongxin Li et al.
Yinyin Ye et al.
Introduction: With the increasing use of trastuzumab deruxtecan (T-DXd) in the treatment of solid tumors, fatigue has emerged as a clinically significant toxicity. We aimed to quantify the risk and incidence of T-DXd-asso...
Myocardial Infarction, Pulmonary Embolism, and Deep Vein Thrombosis Following Testosterone Cypionate Use: A Pharmacovigilance Study [0.03%]
十一酸睾酮使用后的急性心血管事件：一项药物警戒研究
Abhishek Kandukuru,Deepak Gupta,Priyanka Sharma et al.
Abhishek Kandukuru et al.
Introduction: Testosterone Cypionate (TC) is a widely prescribed anabolic steroid for male hypogonadism and gender-affirming hormone therapy. While therapeutically beneficial, concerns have emerged regarding its potential...
Severe Orolingual and Laryngeal Angioedema after Thrombolysis with Alteplase: Angiotensin II Receptor Blockers Should Not Be Underestimated [0.03%]
降纤酶治疗后的严重口腔和喉部血管性水肿：不应低估血管紧张素II受体阻断剂的作用
Lucía González-Bravo,José Barbarroja-Escudero,Ana Laiseca-Antón et al.
Lucía González-Bravo et al.
Introduction: Alteplase is a recombinant tissue plasminogen activator (rt-PA), used for intravenous thrombolysis in ischaemic strokes. Orolingual angioedema is a rare but potentially lifethreatening complication of altepl...
A Meta-Analysis of Efficacy and Safety of Penehyclidine for Postoperative Nausea and Vomiting [0.03%]
丙派拉林镇吐有效性和安全性的 meta 分析研究
Abdulsalam Mohammed Aleid,Mohammed Yousef Almulhim,Muthana Al Sahlawi et al.
Abdulsalam Mohammed Aleid et al.
Introduction: Postoperative nausea and vomiting (PONV) remain among the most frequent and distressing complications following surgery, often hindering patient recovery and comfort. Penehyclidine, an anticholinergic agent, has been explored ...
Meta-Analysis
Current drug safety. 2025 Nov 13. DOI:10.2174/0115748863420846251028103616 2025
Possible Liposomal Amphotericin B-Triggered Intracerebral Hemorrhage in Kala-Azar with Hemophagocytic Lymphohistiocytosis: A Case Study [0.03%]
可能的两性霉素B诱导的黑热病合并噬血细胞性淋巴组织细胞增多症颅内出血病例报道
Shiv Narayan Sahu,Avneet Kumar Gupta,Prasan Kumar Panda et al.
Shiv Narayan Sahu et al.
Introduction: Liposomal amphotericin B is the treatment of choice for visceral leishmaniasis (VL), but its potential adverse effects, including hematologic and neurologic complications, remain a subject of concern. Hemophagocytic lymphohist...
Ecchymosis Induced by Sertraline: A Case Report of a Rare Adverse Reaction [0.03%]
司特拉西安引起的瘀斑一例罕见不良反应的病例报告
Yasmine Salem Mahjoubi,Imen Hamza,Ons Charfi et al.
Yasmine Salem Mahjoubi et al.
Introduction: Sertraline, an SSRI, is widely prescribed for depression and other psychiatric disorders. Although generally well-tolerated, SSRIs can rarely cause bleeding complications due to their effect on platelet aggr...
Evaluation of Hospital Antibiotic Consumption during the COVID-19 Pandemic [0.03%]
新冠肺炎疫情期间医院抗生素消耗评估
Biljana Lazarova,Biljana Eftimova,Maja Simonoska Crcarevska et al.
Biljana Lazarova et al.
Introduction: Antimicrobial resistance (AMR) is a pressing global health issue exacerbated by the overuse of antibiotics during the COVID-19 pandemic. Despite WHO guidelines against antibiotics for mild-to-moderate COVID-...
Clopidogrel-Induced Liver Injury: Clinical Features, Diagnostic Challenges, and Recovery Time - A Systematic Review of Current Reported Cases [0.03%]
氯吡格雷所致肝脏损伤：临床特点、诊断挑战和恢复时间——既往报道病例的系统性回顾
Thanathip Suenghataiphorn,Narisara Tribuddharat,Pojsakorn Danpanichkul et al.
Thanathip Suenghataiphorn et al.
Introduction: Clopidogrel is a widely used agent in the management of cardiovascular disease. However, there have been reports of liver injury associated with its use, some of which have resulted in death. The atypical pr...
Global Analysis of Regulatory Frameworks and Drug Safety Standards in the Drug Approval Process [0.03%]
全球药品审评体系及药物安全标准分析
Virendra S Gomase,Rupali Sharma,Suchita P Dhamane
Virendra S Gomase
The drug approval and review process plays a crucial role in the pharmaceutical industry, aiming to ensure that newly marketed drugs are safe, effective, and of high quality. Regulatory authorities overseeing this process, tailored to geogr...