Mechanistic Insights into Achyranthes Bidentata Blume Water Extract in Alleviating NAFLD: PPARγ-Driven Synergistic Regulation of Lipid Metabolism and Macrophage Efferocytosis [0.03%]
穿心莲内酯通过PPARδ信号诱导自噬改善小鼠非酒精性脂肪肝的机制研究
Xiong Ying Li,Ru Meng Yao,Xiao Ming Zou et al.
Xiong Ying Li et al.
Introduction: Achyranthes bidentata Blume (AB), a traditional Chinese medicine, is used to treat Non-alcoholic fatty liver disease (NAFLD), although its precise mechanism of action remains unclear. This study investigated...
Improving Immune Checkpoint Therapy in the Tumor Microenvironment by Targeting T Cell Metabolism [0.03%]
通过靶向T细胞代谢改善肿瘤微环境中免疫检查点治疗的效果
Jun Wei,Baozhen An,Renchao Dong et al.
Jun Wei et al.
To meet the increased nutrient requirements associated with rapid cellular proliferation, tumor cells undergo metabolic reprogramming, characterized by a substantial increase in the production of energy and precursor molecules necessary for...
Unraveling the Immunomodulatory Mechanisms of Quan-du-zhong Capsule in Diabetic Kidney Disease via Integrated Network Pharmacology and Experimental Validation [0.03%]
基于网络药理学和实验研究四妙丸治疗糖尿病肾病的免疫调控机制解析
Guohua Liu,Chaozhong Zhou,Xunli Xiao et al.
Guohua Liu et al.
Introduction: Quan-du-zhong capsule (QDZ), derived from Eucommia ulmoides Oliv, is clinically utilized for diabetic kidney disease (DKD) management due to its renoprotective effects. Recent studies have demonstrated that ...
Associations of Mercury Exposure with Serum Sex Steroid Hormones in Children 6-18 Years from NHANES 2013-2016 [0.03%]
美国NHANES 2013-2016调查中儿童血清性激素与汞暴露的关系
Binwei Qiu,Yan Lin
Binwei Qiu
Introduction: To examine the relationship between mercury exposure and serum sex steroid hormones among children aged 6-18 years. Methods: ...
Integrated Multiomics Analysis Identifies CDO1 as a Novel Therapeutic Target for Osteoarthritis [0.03%]
整合多组学分析识别出CDO1是治疗骨关节炎的新型药物靶点
Zhihu Zhao,Xiangdong Wu,Duan Wang et al.
Zhihu Zhao et al.
Introduction: This study aimed to identify key genes and potential therapeutic targets involved in the progression of osteoarthritis (OA) through an integrated multi-omics approach. ...
Assessment of Exercise-Stimulated Irisin in Kidney Disease: A Systematic Review [0.03%]
肾病运动刺激irisin的评估：系统性综述
Enzo Shintaku,Davi Vantini,João Gabriel Bicudo Ting et al.
Enzo Shintaku et al.
Introduction: Irisin is a hormone synthesized by skeletal muscle cells in response to physical exercise. It has been linked to various health benefits, including improved insulin sensitivity, fat burning, reduced inflamma...
Bibliometric Analysis of Emerging Trends and Hotspots in the Links between Nonalcoholic Steatohepatitis and Diabetes Mellitus from 2004 to 2023 [0.03%]
2004-2023年非酒精性脂肪肝与糖尿病关联研究的新兴趋势和热点文献计量分析
Chen Xie,Tao Liu,Yuanxin Zhong et al.
Chen Xie et al.
Introduction: In recent years, the prevalence of nonalcoholic steatohepatitis (NASH) has been rising globally. NASH has been linked to liver fibrosis, cirrhosis, hepatocellular carcinoma (HCC), and liver transplantation (...
Association of Anti-TPO Antibody and Inflammatory Markers with Thyroid Ultrasound Findings [0.03%]
抗TPO抗体和炎症标志物与甲状腺超声结果的关系
Ersin Kuloglu,Kubilay Issever,Ali Muhtaroglu et al.
Ersin Kuloglu et al.
Introduction: The objective of this study was to evaluate the demographic, clinical, laboratory, and ultrasonographic characteristics of patients diagnosed with subclinical hypothyroidism, with a particular emphasis on th...
Comparative Analysis Revealed Circulating Methylation of PDGFRB Highly Related with Rheumatoid Arthritis Related Diseases [0.03%]
基于比较分析的血清DNA甲基化标志物PDGFRB在风湿性疾病中的临床诊断价值研究
Yu Shan,Mengru Guo,Jia Liu et al.
Yu Shan et al.
Introduction: To investigate the DNA methylation levels of platelet-derived growth factor receptor- B [PDGFRB] cg25613180 across rheumatoid arthritis [RA] and various further rheumatic disorders, including ankylosing spon...
Analysis of Necroptosis-Related Genes and Immune Cell Infiltration in Infantile Hemangioma [0.03%]
婴儿血管瘤中坏死性凋亡相关基因及免疫细胞浸润分析
Yunpeng Xu,Jiajie Chen,Zhihao Huang et al.
Yunpeng Xu et al.
Introduction: Infantile hemangioma (IH) is the most prevalent benign tumor in neonates, yet the role of necroptosis in its pathogenesis remains underexplored. This study aimed to investigate necroptosis-related gene expre...