Genetic Causal Association between Treg Subtypes and Acute Respiratory Distress Syndrome: A Mendelian Randomization Study [0.03%]
基于孟德尔随机化研究的Treg亚型与急性呼吸窘迫综合征的遗传因果关联分析
Hongyang Xu,Lang Li,Zhencang Zheng et al.
Hongyang Xu et al.
Introduction: Observational research has indicated a link between regulatory T-cells (Tregs) and the risk of acute respiratory distress syndrome (ARDS). However, establishing a definitive causal relationship has been chal...
A Predictive Model for Anemia and Coronary Heart Disease Based on Bidirectional Two-Sample Mendelian Randomization and Machine Learning [0.03%]
基于双向两样本孟德尔随机化和机器学习的贫血及冠心病预测模型
Yan Zhang,Sheng Fan,Pengcheng Ma et al.
Yan Zhang et al.
Introduction: Anemia has been linked to an increased risk of coronary heart disease (CHD), yet the underlying causal relationship remains unclear. This study aimed to investigate the bidirectional associations between ane...
Living with PCOS: A Narrative of Its Biology, Diagnosis, and Evolving Treatment [0.03%]
PCOS伴行：其生物学、诊断及治疗方法的发展历程叙事
Samya Shams,Shagufta Jawaid,Nisha Rai et al.
Samya Shams et al.
Introduction: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder characterized by hyperandrogenism, ovarian dysfunction, and metabolic abnormalities. It affects between 4% and 21% of females of fertile age. ...
Exploring In Vivo Anti-Diabetic Potential of 2,3 and 2,6-dichloroindolinone: Biochemical and Histological Evidences [0.03%]
体内抗糖尿病潜能的探索：2、3和2、6-二氯吲哚酮的生化和组织学证据
Abdur Rauf,Waqas Alam,Momin Khan et al.
Abdur Rauf et al.
Introduction: The high global prevalence of diabetes and treatment noncompliance is a great clinical challenge. Thus, the need for anti-diabetic medications is critical. In this regard, in vivo antidiabetic potential of t...
Metformin Alone and in Combinations Alter the Methylation Patterns of ABCG1 and TXNIP Loci in Patients of Type 2 Diabetes [0.03%]
二甲双胍及其联合用药通过改变ABCG1和TXNIP位点的甲基化模式改善2型糖尿病患者的功能指标研究
Shehla Shaheen,Shamim Mushtaq,Zahida Memon et al.
Shehla Shaheen et al.
Background: DNA methylation, being a predictor of gene-environment interaction, a dynamic and reversible process, and a target of drugs, may help clinicians to step towards precision medicine. Epigenome-wide association s...
Genetic Pathogenesis and Treatment of Forkhead Box A2 Hyperinsulinemia [0.03%]
FOXA2基因突变导致的高胰岛素血症的发病机制及治疗研究进展
Yangmingyue Ji,Congli Chen,Yanmei Sang
Yangmingyue Ji
Congenital hyperinsulinemia (CHI) is a clinically heterogeneous disorder that is the leading cause of persistent and recurrent hypoglycemia in infancy and childhood. There are 39 pathogenic genes associated with CHI. The forkhead box A2 (FO...
Exploring the Influence of Demographic and Clinical Parameters on Knowledge, Attitudes, and Practices in Type-II Diabetes Mellitus Patients in Punjab, India: A Cross-Sectional Study [0.03%]
探索印度旁遮普邦2型糖尿病患者人口统计学和临床参数对知识、态度和行为的影响：一项横断面研究
Sandeep Kaur,Sidharth Mehan,Ghanshyam Das Gupta
Sandeep Kaur
Background: Diabetes mellitus is a global health issue, affecting over 6.2% of the population. Effective management of type II diabetes mellitus (DM II) depends largely on patients' knowledge, attitudes, and practices (KA...
Functional Enrichment, Drug Prediction, and Molecular Docking to Identify Fibroblast-Related Biomarkers for Gastric Cancer via High-Dimensional Weighted Gene Co-Expression Network Analysis [0.03%]
基于高维加权基因共表达网络分析的胃癌成纤维细胞相关生物标志物的功能富集、药物预测及分子对接研究
Hongpeng Lu,Suqi Lan,Xu Yuan et al.
Hongpeng Lu et al.
Introduction: Cancer-associated fibroblasts (CAFs) can promote gastric cancer (GC) progression through regulating the tumor microenvironment (TME). This study explored cell-to-fibroblast communication based on the single-...
Incidence of Hirschsprung Disease at the Central Pediatrics Teaching Hospital in Iraq: A Pathological Overview [0.03%]
伊拉克中央儿科教学医院的先天性巨结肠病发病率：病理概览
Ikram Fakhri Abed Al-Zughaibi,Nada K Mehdi,Hany Akeel Al-Hussaniy
Ikram Fakhri Abed Al-Zughaibi
Background: Hirschsprung disease (HD) is a congenital disorder associated with specific missense mutations in the RET proto-oncogene. This study aimed to demonstrate the incidence of Hirschsprung disease and its clinical ...
Exploration of the Mechanism of Erchen Decoction in Ameliorating Obesity by Regulating Lipid Deposition via the AMPK/SIRT1/PGC-1α Signaling Pathway [0.03%]
二陈汤调节脂代谢改善肥胖的机制研究：AMPK/SIRT1/PGC-1α信号通路视角
Yue Luo,Hao Gao,Zhuo Zhao et al.
Yue Luo et al.
Introduction: Obesity, a global health crisis, necessitates innovative therapeutic strategies. Traditional Chinese Medicine (TCM), including Erchen Decoction (ECD), offers potential benefits; however, the molecular mechanisms underlying ECD...