Genetic Prediction of Causal Association Between Celiac Disease and Thyroid Function: A Two-Sample Mendelian Randomized Study [0.03%]
基于孟德尔随机化研究的遗传预测揭示乳糜泻和甲状腺功能之间因果关联
Xiaoshun He,Hanxin Lv,Wangjianfei Yu et al.
Xiaoshun He et al.
Aim: Observational studies have suggested an association between celiac disease and thyroid dysfunction, but their causal relationship has not yet been established. ...
Danshenol A Mediates the Proliferation and Differentiation of Adipocytes in Thyroid-Associated Ophthalmopathy [0.03%]
丹参醌A介导突眼症脂肪细胞的增殖和分化
Yuting Chen,Jie Min,Xiali Yu et al.
Yuting Chen et al.
Introduction: An increase in the intraorbital adipose tissue is the main pathological feature of thyroid-associated ophthalmopathy (TAO). IGF-1R activates PI3K/AKT signaling and accelerates adipogenesis. Pingmu decoction ...
The Mediating Role of Blood Metabolites in the Association between Basal Metabolic Rate and Obstetrical Disorders: A Mendelian Randomization Analysis [0.03%]
基于孟德尔随机化分析的基线代谢率与妊娠并发症相关性的中介代谢物研究
Yanqiong Gan,Xinlin Tan,Yu Tang et al.
Yanqiong Gan et al.
Introduction: Previous studies suggest a link between Basal Metabolic Rate (BMR) and obstetrical disorders; however, causality remains unclear. We investigated the causal effects of BMR on 14 obstetric disorders and evalu...
Metabolic Disease Management through Natural Products: A Thorough Exploration [0.03%]
天然产物在代谢病防治中的作用及机制研究进展
Pranav Kumar Prabhakar
Pranav Kumar Prabhakar
NLRP3 Inflammasome: A New Perspective on Revealing Hotspots and Trends in Uric Acid Metabolism Disorders through Bibliometric Analysis [0.03%]
基于文献计量学分析的尿酸代谢障碍研究热点及趋势的新视角——NLPR3炎症小体
Yi Xu,Yu Wang,Chengjin Lu et al.
Yi Xu et al.
Uric acid metabolism disorders have become major health concerns, primarily causing conditions such as hyperuricemia, uric acid nephropathy, and gout. Recent research has focused on these disorders' underlying pathological mechanisms and ph...
The Combination Therapy of Pasireotide LAR Plus Pegvisomant and Cabergoline Relieved Acromegaly-Related Headache in a Female Patient with AIP-Mutated Acromegaly: A Case Report [0.03%]
一例AIP突变型肢端肥大症女性患者的联合治疗可缓解肢端肥大症相关性头痛：个案报告
Penelope Giambò,Sabrina Chiloiro,Antonella Giampietro et al.
Penelope Giambò et al.
Introduction: Acromegaly is a rare condition characterized by excessive exposure to GH and IGF-1 due to a pituitary adenoma in most cases. The disease is associated with numerous symptoms, including headaches, which are f...
Associations of Anthropometric Indicators with Bone Mineral Density and the Risk of Bone Fractures and Falls: A Large-Scale Genetic Correlation Study [0.03%]
体质指数与骨密度和骨折及跌倒风险的关联：一项大规模遗传相关性研究
Xiao Hu,Zhao-Xing Gao,Yan-Yu Zhu et al.
Xiao Hu et al.
Introduction: Although observational studies have suggested potential associations between Anthropometric Indicators (AIs), Osteoporosis (OP), and bone fractures, the causal links are still scarce. This study aimed to com...
Identifying AIM2 Circulating Methylation Levels as a Novel Diagnostic Biomarker for Rheumatoid Arthritis Using Targeted DNA Methylation Sequencing [0.03%]
利用目标DNA甲基化测序鉴定AIM2循环甲基化水平作为类风湿性关节炎新型诊断生物标志物
Jianan Zhao,Binghen He,Yu Shan et al.
Jianan Zhao et al.
Introduction: This study investigated the association between AIM2 cg11003133 DNA methylation and Rheumatoid Arthritis (RA), evaluating its diagnostic potential for RA and subtypes. ...
Palmatine Ameliorates High-Temperature and High-Humidity-Induced Enteritis Via Mitophagy and NLRP3 Inflammasome Degradation [0.03%]
掌叶防己碱通过线粒体自噬降解NLRP3炎性小体改善高温高湿诱发的肠炎
Xiaoying Mo,Tai Mi,Wanli Liu et al.
Xiaoying Mo et al.
Background: Previous studies have shown that a High-Temperature- and High-Humidity (HTH) environment leads to mild enteritis, accompanied by impaired mitophagy and activated NLRP3-IL-1β, as found in Inflammatory Bowel Di...
Yipishen Xiezhuo Jiedu Decoction in Ameliorating Kidney Damage Through miR-223/NLRP3/ Caspase-1 Pathway [0.03%]
益皮肾拙解毒汤通过miR-223/NLRP3/Caspase-1信号通路改善肾脏损伤的机制研究
Jianfei Weng,Dengyong Zheng,Huijun Chen et al.
Jianfei Weng et al.
Introduction: Hyperuricemia Nephropathy (HN) is an emerging metabolic disorder that predisposes individuals to Chronic Kidney Disease (CKD), yet effective treatments remain limited. Inflammation plays a pivotal role in HN-induced kidney inj...