FOXO4 enhances high glucose-induced HK-2 cell damage and inflammation by targeting TFPI2 in diabetic nephropathy [0.03%]
FOXO4通过靶向TFPI2增强高糖诱导的HK-2细胞损伤和炎症以治疗糖尿病肾病
Liqin Mu,Yu Zhao,Yang Li et al.
Liqin Mu et al.
Background: Diabetic nephropathy (DN) represents the leading cause of end-stage renal disease; however, its molecular mechanisms remain incompletely understood. This study aims to elucidate the specific roles and regulato...
Beyond current standards: combination therapy and emerging targets in diabetic kidney disease [0.03%]
超越标准：糖尿病肾病的联合治疗和新兴靶点
Jiwon Lee,Mi-Yeon Yu;Korean Diabetic Kidney Disease Study Group
Jiwon Lee
Diabetic kidney disease continues to be a major contributor to kidney failure and is strongly associated with adverse cardiovascular outcomes. Even with routine use of renin-angiotensin system blockade, many patients show ongoing disease pr...
A new era in diabetic kidney disease therapy: toward remission and survival [0.03%]
糖尿病肾脏疾病治疗的新时代：迈向缓解和生存
Eun Young Lee
Eun Young Lee
Machine learning-assisted prediction of 5-year mortality in chronic kidney disease: the KoreaN cohort study for Outcome in patients With Chronic Kidney Disease (KNOW-CKD) [0.03%]
基于韩国慢性肾脏病患者结局队列(KNOW-CKD)研究的机器学习助力慢性肾病患者5年死亡率预测模型
Sang Heon Suh,Hong Sang Choi,Chang Seong Kim et al.
Sang Heon Suh et al.
Background: Mortality prediction models for patients with non-dialysis chronic kidney disease (CKD) remain limited despite their clinical importance. While machine learning (ML) offers the potential to improve prediction ...
Rationale and design of the EXCELSIOR-CKD trial: intensive blood pressure and lipid control in advanced chronic kidney disease [0.03%]
EXCELSIOR-CKD试验的设计和原理：在慢性肾脏病晚期强化血压和血脂控制
Yaerim Kim,Jwa-Kyung Kim,Gang-Jee Ko et al.
Yaerim Kim et al.
Background: Although blood pressure and lipid control are key in advanced chronic kidney disease (CKD), the optimal targets for systolic blood pressure (SBP) and low-density lipoprotein cholesterol (LDL-C) remain unclear ...
Prognostic stratification in a diabetic kidney disease trial using plasma concentrations of soluble tumor necrosis factor receptor 1 [0.03%]
糖尿病肾脏疾病试验中利用血浆可溶性肿瘤坏死因子受体1浓度进行预后分层
Vladimir Petrovic,Vladislav A Malkov,Andrew N Billin et al.
Vladimir Petrovic et al.
Background: Concentration of circulating soluble tumor necrosis factor receptor 1 is associated with faster progression in patients with diabetic kidney disease based on data obtained from large longitudinal cohort studie...
Unlocking potassium secretion: the roles of aldosterone, ROMK, and WNK kinases in kidney potassium handling [0.03%]
解锁钾分泌：醛固酮、ROMK和WNK激酶在肾脏钾处理中的作用
Biff F Palmer
Biff F Palmer
The normal human kidney possesses a prodigious capacity to excrete dietary potassium (K+). This evolutionary adaptation is rooted in the high-K+ diets of prehistoric hominids, which are estimated to have reached 15,000 mg/day. Despite the p...
Response to the letter regarding "Genetic diagnosis of hereditary kidney disease in pediatric patients through whole-exome sequencing and mitochondrial DNA analysis" [0.03%]
关于“通过外显子组测序和线粒体DNA分析对儿科患者遗传性肾脏疾病的基因诊断”的回信
Jiyoung Oh,Keumwha Lee,Dongju Won et al.
Jiyoung Oh et al.
Initial effect of sodium-glucose cotransporter-2 inhibitors on kidney function in patients with immunoglobulin A nephropathy [0.03%]
钠葡萄糖共转运蛋白2抑制剂对免疫球蛋白A肾病患者肾脏功能初始影响的效果观察
Jae Young Kim,Ji Hye Kim,Sung-Eun Choi et al.
Jae Young Kim et al.
Background: Optimized supportive therapy, including maximal renin-angiotensin-aldosterone system (RAAS) inhibition, is not always adequate in patients with IgA nephropathy (IgAN). This study evaluated the early effects of...
Glomerular hyperfiltration in dipstick-negative type 2 diabetes mellitus: a novel determinant of kidney function decline in type 2 diabetes mellitus [0.03%]
尿糖阴性的2型糖尿病患者肾小球高滤过：2型糖尿病患者肾功能下降的新决定因素
Dughyun Choi,Samel Park,Dong-Sub Kim et al.
Dughyun Choi et al.
Background: The independent impact of type 2 diabetes mellitus (T2DM) on kidney outcomes beyond albuminuria remains unclear. We evaluated whether T2DM affects kidney outcomes in individuals with normal kidney function wit...