Wen-Ling Liao,Fuu-Jen Tsai
Wen-Ling Liao
Type 2 diabetes (T2D) is a global public health concern, its prevalence in Asia, especially Taiwan, rising every year. The risk of developing T2D and diabetes complications is not only controlled by environmental but also by genetic factors...
Case report of Chromosome 3q25 deletion syndrome or Mucopolysaccharidosis IIIB [0.03%]
染色体3q25缺失综合征或二氏黏多糖病病例报告
Yu-Tzu Chang,Chung-Hsing Wang,I-Ching Chou et al.
Yu-Tzu Chang et al.
Interstitial deletions of the long arm of chromosome 3 have, to our knowledge, been reported in only eleven patients; detailed genotype- phenotype correlations are not well established. Here we describe a case with interstitial deletion inv...
Metabolic Abnormality and Sleep Disturbance are Associated with Clinical Severity of Patients with Schizophrenia [0.03%]
代谢异常和睡眠障碍与精神分裂症患者的临床严重程度有关
Chung-Chieh Hung,Chin-Chih Liao,Po-Lun Wu et al.
Chung-Chieh Hung et al.
Schizophrenic patients suffer from more metabolic or sleep problems. Little is known about risk factors. We recruited 17 patients with chronic schizophrenia from the rehabilitation center in a medical center in Taiwan and measured their dem...
Protective effects from Houttuynia cordata aqueous extract against acetaminophen-induced liver injury [0.03%]
鱼腥草提取物对乙酰氨基酚致肝损伤的保护作用
Wei-Ting Chen,Chieh-Ling Yang,Mei-Chin Yin
Wei-Ting Chen
Background: Protective effects of Houttuynia cordata aqueous extract (HCAE) against acetaminophen-induced hepatotoxicity in Balb/cA mice were examined. Me...
Vascular Endothelial Growth Factor -460 C/T BstUI Gene Polymorphism is associated with Primary Open Angle Glaucoma [0.03%]
血管内皮生长因子-460CT基因多态性与原发性开角型青光眼相关性研究
Hui-Ju Lin,Wen-Lu Chen,Ter-Hsin Chen et al.
Hui-Ju Lin et al.
Background: Hypoxia and nitric oxide (NO) play important roles in the onset and progression of glaucoma. Vascular endothelial growth factor (VEGF) is one of the main factors responsive to hypoxia and NO. In this study, we...
Contribution of personalized Cyclin D1 genotype to triple negative breast cancer risk [0.03%]
cyclinD1基因多态性与三阴性乳腺癌发病风险的相关性研究
Liang-Chih Liu,Chen-Hsien Su,Hwei-Chung Wang et al.
Liang-Chih Liu et al.
Aim: Cell cycle regulator cyclin D1 (CCND1) is a pivotal regulator for G1/S phase transition, playing a critical part in initiation of carcinogenesis. Triple negative breast cancer comprises a very heterogeneous group of cancer cells, but l...
Evolving Personalized Therapy for Castration-Resistant Prostate Cancer [0.03%]
去势抵抗性前列腺癌的治疗现状及个性化治疗进展
Hsin-Ho Liu,Yuh-Shyan Tsai,Chen-Li Lai et al.
Hsin-Ho Liu et al.
With advances in molecular biologic and genomic technology, detailed molecular mechanisms for development of castration-resistant prostate cancer (CRPC) have surfaced. Metastatic prostate cancer (PCa) no longer represents an end stage, with...
Long-Yuan Li
Long-Yuan Li
Enhancer of Zeste homlog 2 (EZH2) is a catalytic subunit of epigenetic regulator Polycomb repressive complex 2 (PRC2), which trimethylates Lys 27 of histone H3, leading to silencing of the target genes that are involved in a variety of biol...