The contributions of the tissue inhibitor of metalloproteinase-1 genotypes to triple negative breast cancer risk [0.03%]
基质金属蛋白酶组织抑制剂-1基因多态性与三阴性乳腺癌风险相关性研究
Wen-Shin Chang,Liang-Chih Liu,Chieh-Lun Hsiao et al.
Wen-Shin Chang et al.
The tissue inhibitors of metalloproteinases (TIMPs) are a family of multifunctional proteins which have been shown to be upregulated in various types of cancers. However, the contribution of TIMPs in breast cancer is not fully understood, n...
Ling-Chu Chang,Yung-Luen Yu
Ling-Chu Chang
Carcinogenesis is a complicated process that involves the deregulation of epigenetics resulting in cellular transformational events, such proliferation, differentiation, and metastasis. Epigenetic machinery changes the accessibility of chro...
PPARα modulates gene expression profiles of mitochondrial energy metabolism in oral tumorigenesis [0.03%]
PPARα调节口腔肿瘤发生过程中线粒体能量代谢基因表达谱式
Yi-Ping Huang,Nai Wen Chang
Yi-Ping Huang
Metabolic reprogramming plays a crucial role in the development of cancer. The aim of this study was to explore the effect of fenofibrate, an agonist of peroxisome proliferator-activated receptor alpha (PPARα), on gene expression profiles ...
Epigenetics, TET proteins, and hypoxia in epithelial-mesenchymal transition and tumorigenesis [0.03%]
表观遗传学、TET蛋白和低氧在上皮间质转化及肿瘤发生中的作用
Hsiao-Fan Chen,Kou-Juey Wu
Hsiao-Fan Chen
Hypoxia in tumors is primarily a pathophysiologic consequence of structurally and functionally disturbed microcirculation with inadequate supply of oxygen. Tumor hypoxia is strongly associated with tumor propagation, malignant progression, ...
Tsing-Fen Ho,Chia-Che Chang
Tsing-Fen Ho
An ideal cancer therapy specifically targets cancer cells while sparing normal tissues. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) elicits apoptosis by engaging its cognate death receptors (DRs-namely, DR4 and DR5. The ...
Influencing and moderating factors analyzed in the group art therapy of two schizophrenic inpatients [0.03%]
两位精神分裂症住院患者的团体艺术治疗中的影响因素及调变因素分析
Chung-Chieh Hung,Yung-Wen Ku
Chung-Chieh Hung
Art therapy has been considered a guideline treatment for schizophrenia. Due to difficulty in the outcome measurement, the research is difficult and controversial. Here, we presented two schizophrenic patients receiving the regular art grou...
Wound dressings - a review [0.03%]
伤口敷料研究进展
Selvaraj Dhivya,Viswanadha Vijaya Padma,Elango Santhini
Selvaraj Dhivya
Wound healing is a dynamic and complex process which requires suitable environment to promote healing process. With the advancement in technology, more than 3000 products have been developed to treat different types of wounds by targeting v...
Nutrition, psychoneuroimmunology and depression: the therapeutic implications of omega-3 fatty acids in interferon-α-induced depression [0.03%]
营养、心理神经免疫学与抑郁：ω-3脂肪酸在干扰素诱导的抑郁中的治疗意义
Kuan-Pin Su
Kuan-Pin Su
The unmet need of current pharmacotherapy and the high occurrence of somatic symptoms and physical illness in depression imply that the 'monoamine hypothesis' is insufficient in approaching the aetiology of depression. Clinically, depressed...
Assessing the risk: Scoring systems for outcome prediction in emergency laparotomies [0.03%]
评估风险：急诊开腹手术结局预测评分系统
Deb Sanjay Nag
Deb Sanjay Nag
Emergency laparotomy is the commonest emergency surgical procedure in most hospitals and includes over 400 diverse surgical procedures. Despite the evolution of medicine and surgical practices, the mortality in patients needing emergency la...
Viswanadha Vijaya Padma
Viswanadha Vijaya Padma
Cancer is a multifactorial disease and is one of the leading causes of death worldwide. The contributing factors include specific genetic background, chronic exposure to various environmental stresses and improper diet. All these risk facto...