Current concepts regarding developmental mechanisms in diabetic retinopathy in Taiwan [0.03%]
台湾地区关于糖尿病视网膜病变发病机制的当前概念
Shih-Yin Chen,Yuan-Man Hsu,Ying-Ju Lin et al.
Shih-Yin Chen et al.
Diabetic retinopathy (DR) is one of the most feared complications of diabetes and is a leading cause of acquired blindness in working adults. The prevalence of undiagnosed diabetes in Taiwan is about 4%, and the annual incidence of T2D (Typ...
Solitary renal metastasis of esophageal squamous cell carcinoma mimicking primary renal neoplasm - A case report and literature review [0.03%]
食管鳞癌肾转移误诊为肾脏肿瘤一例报告及文献复习
Kai-Po Chang,Chi-Ping Huang,Han Chang
Kai-Po Chang
Solitary renal metastasis of esophageal cancer is rare clinically, with only 14 cases being reported in the literature. The authors here report a case of a 53-year-old man with a metachronous hypopharyngeal and esophageal squamous cell carc...
M2 macrophage polarization modulates epithelial-mesenchymal transition in cisplatin-induced tubulointerstitial fibrosis [0.03%]
M2型巨噬细胞极化调节顺铂诱导的肾小管间质纤维化中的上皮间质转化
Chia-Cherng Yu,Chiang-Ting Chien,Tzu-Ching Chang
Chia-Cherng Yu
Cisplatin-induced nephrotoxicity leaded to apoptosis of tubular epithelial cells (ECs) and tubulointerstitial fibrosis through ROS stress and inflammatory cytokines. Tubulointerstitial fibrosis caused by cisplatin might be via activation of...
The contributions of the tissue inhibitor of metalloproteinase-1 genotypes to triple negative breast cancer risk [0.03%]
基质金属蛋白酶组织抑制剂-1基因多态性与三阴性乳腺癌风险相关性研究
Wen-Shin Chang,Liang-Chih Liu,Chieh-Lun Hsiao et al.
Wen-Shin Chang et al.
The tissue inhibitors of metalloproteinases (TIMPs) are a family of multifunctional proteins which have been shown to be upregulated in various types of cancers. However, the contribution of TIMPs in breast cancer is not fully understood, n...
Ling-Chu Chang,Yung-Luen Yu
Ling-Chu Chang
Carcinogenesis is a complicated process that involves the deregulation of epigenetics resulting in cellular transformational events, such proliferation, differentiation, and metastasis. Epigenetic machinery changes the accessibility of chro...
PPARα modulates gene expression profiles of mitochondrial energy metabolism in oral tumorigenesis [0.03%]
PPARα调节口腔肿瘤发生过程中线粒体能量代谢基因表达谱式
Yi-Ping Huang,Nai Wen Chang
Yi-Ping Huang
Metabolic reprogramming plays a crucial role in the development of cancer. The aim of this study was to explore the effect of fenofibrate, an agonist of peroxisome proliferator-activated receptor alpha (PPARα), on gene expression profiles ...
Epigenetics, TET proteins, and hypoxia in epithelial-mesenchymal transition and tumorigenesis [0.03%]
表观遗传学、TET蛋白和低氧在上皮间质转化及肿瘤发生中的作用
Hsiao-Fan Chen,Kou-Juey Wu
Hsiao-Fan Chen
Hypoxia in tumors is primarily a pathophysiologic consequence of structurally and functionally disturbed microcirculation with inadequate supply of oxygen. Tumor hypoxia is strongly associated with tumor propagation, malignant progression, ...
Tsing-Fen Ho,Chia-Che Chang
Tsing-Fen Ho
An ideal cancer therapy specifically targets cancer cells while sparing normal tissues. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) elicits apoptosis by engaging its cognate death receptors (DRs-namely, DR4 and DR5. The ...
Influencing and moderating factors analyzed in the group art therapy of two schizophrenic inpatients [0.03%]
两位精神分裂症住院患者的团体艺术治疗中的影响因素及调变因素分析
Chung-Chieh Hung,Yung-Wen Ku
Chung-Chieh Hung
Art therapy has been considered a guideline treatment for schizophrenia. Due to difficulty in the outcome measurement, the research is difficult and controversial. Here, we presented two schizophrenic patients receiving the regular art grou...
Wound dressings - a review [0.03%]
伤口敷料研究进展
Selvaraj Dhivya,Viswanadha Vijaya Padma,Elango Santhini
Selvaraj Dhivya
Wound healing is a dynamic and complex process which requires suitable environment to promote healing process. With the advancement in technology, more than 3000 products have been developed to treat different types of wounds by targeting v...