The cooperative regulation of miR-221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer [0.03%]
APE1和AUF1对miR-221的联合调控及其对p27(Kip1)的影响，定义了宫颈癌中一个与微小核糖核酸相关的标志物组合
Matilde Clarissa Malfatti,Nicolò Gualandi,Gianluca Tell et al.
Matilde Clarissa Malfatti et al.
Apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) is a multifunctional protein involved in DNA repair, transcriptional regulation, and redox signaling, which significantly contributes to cancer progression and chemoresistance. Recent stu...
Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short-term immobilization [0.03%]
短期制动所致骨骼肌铁代谢紊乱及脂质过氧化反应变化规律的研究
Haruka Yokogawa,Kazuhiko Higashida,Naoya Nakai
Haruka Yokogawa
Disuse-induced muscle atrophy may involve dysregulated iron metabolism, yet the underlying mechanisms are unclear. We examined iron homeostasis in mouse gastrocnemius muscle following 14-day casting-induced immobilization. Muscle mass decli...
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum [0.03%]
肌萎缩侧索硬化患者血清中载脂蛋白的系统失调现象
Finula I Isik,Russell Pickford,Hannah C Timmins et al.
Finula I Isik et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron degeneration. Increasing evidence implicates systemic lipid perturbation in ALS pathogenesis. However, the extent and nature...
C Valeria L Giosafatto,Marika Avitabile,Michela Famiglietti et al.
C Valeria L Giosafatto et al.
Fossil-based material manufacturing has long been linked to the acceleration of climate change through carbon dioxide emissions. In addition to their negative impact on the environment, the depletion of nonrenewable fossil fuels has led to ...
Evolutionarily divergent DUF4465 domains have a common vitamin B12-binding function [0.03%]
进化上不同的DUF4465结构域具有共同的维生素B12结合功能
Charlea Clarke,Michal Banasik,Rokas Juodeikis et al.
Charlea Clarke et al.
The DUF4465 family (DUF, domain of unknown function) contains more than 1000 members distributed across eight bacterial clades with species from diverse microenvironments including various gut microbiomes, hydrothermal vents, and soil. In t...
Targeting TNBC: core-shell polycationic polyurea dendrimers with inherent anticancer activity [0.03%]
用于靶向TNBC的具有固有抗肿瘤活性的核壳式聚阳离子聚脲树状分子
Adriana Cruz,Bruna Abreu,Cindy Mendes et al.
Adriana Cruz et al.
Breast carcinoma (BC) is the most common malignancy in women, with triple-negative breast cancer (TNBC) making up 10-20% of cases. TNBC has limited targeted therapies and poor survival due to late diagnosis and metastasis. Dendrimers are pr...
Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data [0.03%]
串晶数据中构象微小变化和低占据状态的意义分析
Jake Hill,Yelyzaveta Pulnova,Elke De Zitter et al.
Jake Hill et al.
The interpretation of electron density maps from time-resolved serial diffraction experiments is often hindered by incomplete initiation and mixtures of states. Additionally, it can be challenging to determine the significance of small conf...
MiR-513a promotes human erythroid differentiation by modulating c-Jun [0.03%]
miR-513a通过调节c-Jun促进人红细胞分化
MinJung Kim,Brittany Taylor,Shannon Bolten et al.
MinJung Kim et al.
Erythropoiesis is a highly coordinated process that generates mature red blood cells from hematopoietic stem-progenitor cells (HSPCs). Erythropoietin (EPO) is a major regulator of erythropoiesis and binds to the erythropoietin receptor (EPO...
Screening and epitope characterization of Nidogen-2-specific nanobodies [0.03%]
用于筛选和鉴定Nidogen-2特异性纳米抗体的文库构建及初步筛选研究
Jianchuan Wen,Qianqian Cui,Zhongyun Lan et al.
Jianchuan Wen et al.
NID2 is a key component of the BM and plays an important role in ECM organization and tumor-associated microenvironmental remodeling. In this study, full-length recombinant NID2 was used as an antigen to immunize camels, and a nanobody phag...
YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana [0.03%]
拟南芥YLMG1蛋白定位在叶绿体被膜上并参与质外蛋白的转运
Mengyi Li,Xueyang Zhao,Masato Nakai
Mengyi Li
In green lineages, chloroplast protein import is mediated by conserved TOC and TIC translocons at the outer and inner envelope membranes, respectively. A recent structural study on TIC from Chlamydomonas reinhardtii revealed an additionally...