Krystyna Mazan-Mamczarz,Eleanor J Wind,Jixiang Leng et al.
Krystyna Mazan-Mamczarz et al.
Cellular senescence represents a response to sublethal damage, characterized by persistent growth arrest and a robust pro-inflammatory trait, the senescence-associated secretory phenotype (SASP). Senescent cells accumulate in the body with ...
Large-scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation [0.03%]
大规模双向阵列式基因筛选鉴定出OXR1和EMC4为α-突触核蛋白聚集修饰因子
Sandesh Neupane,Lea Nikolić,Lorenzo Maraio et al.
Sandesh Neupane et al.
In Parkinson's disease and other synucleinopathies, αSynuclein (αSyn) misfolds and forms Ser129-phosphorylated aggregates (pSyn129) with the factors controlling this process largely unknown. Here, we used arrayed CRISPR-mediated gene acti...
Enzymatic and microbial routes to bioplastics: The green chemistry frontier of biopolymers [0.03%]
酶和微生物制备生物塑料的途径：生物聚合物绿色化学的前沿领域
Giovanni Gallo,Emma Piccoli,Luca Bombardi et al.
Giovanni Gallo et al.
The rapid escalation of global plastic consumption, coupled with the environmental impacts of petrochemical polymers, has sparked a surge of interest in bioplastics, particularly those derived from microbial and enzymatic processes. This re...
Blood-based proteomic profiling reveals context-dependent changes in BCL2-associated signaling during taxane therapy in breast cancer patients [0.03%]
基于血液的蛋白质组学分析揭示了紫杉烷治疗期间乳腺癌患者BCL2相关信号通路的变化
Saira Munshani,Eiman Y Ibrahim,Rozalyn L Rodwin et al.
Saira Munshani et al.
The quality of life for many cancer survivors is compromised due to severe, long-lasting side effects of chemotherapy. As part of a pilot, prospective, non-interventional study to examine the side effects of chemotherapy in breast cancer pa...
Decreased cold-sensing function of the transient receptor potential channel TRPM8 from tailed amphibians [0.03%]
具有尾部的两栖动物瞬时受体电位通道TRPM8冷感受功能下降
Tadahiro Sawao,Daiki Kobayashi,Shogo Hori et al.
Tadahiro Sawao et al.
Sensing environmental temperature is a complex process involving an array of channels expressed by nociceptive sensory neurons but is critical to allow animals to move away from suboptimal environments and find environments with ideal tempe...
Combined 5-aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells [0.03%]
5-氨基乙酰丙酸和枸橼酸铁铵联合治疗通过激活毛乳头细胞促进毛囊生长
Han-Wook Ryu,Eok-Soo Oh,Sewoon Kim
Han-Wook Ryu
Although 5-aminolevulinic acid (5-ALA) has shown potential for hair growth in previous studies, the molecular mechanisms remain unclear. In this study, we investigated the combined effect of 5-ALA with ferric ammonium citrate (FAC) in human...
Rapid screening of staphylokinase protein variants using an unpurified cell-free expression system [0.03%]
基于未经纯化的细胞 free 表达系统快速筛选蛋白变异体
Maria Tomková,Veronika Hovanová,Jiri Damborsky et al.
Maria Tomková et al.
Protein engineering approaches, including rational design and directed evolution, are essential for optimizing protein properties in biotechnology. However, their application is often limited by the need to experimentally characterize large...
Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin - albumin fusion [0.03%]
人乳铁蛋白-白蛋白融合蛋白通过使细胞器碱化抑制肺腺癌迁移
Hana Nopia,Masahiro Kimura,Daisuke Kurimoto et al.
Hana Nopia et al.
The fusion of human serum albumin with human lactoferrin (hLF-HSA) exerts strong anti-migratory effects in human lung adenocarcinoma cells through matrix metalloproteinase 1 (MMP1) downregulation. We demonstrate that hLF-HSA disrupts organe...
Mass spectrometry based identification of AMP-O-Tris generated by Thermococcus onnurineus Cas10 [0.03%]
利用质谱法基于T。onnurineus cas10鉴定由amp-o-tris生成的方法
Su-Jin Lee,Ga Seul Lee,JinHan Kim et al.
Su-Jin Lee et al.
Cas10, the catalytic core of type III CRISPR-Csm systems, synthesizes cyclic oligoadenylate (cOA) second messengers to activate downstream immune responses. Although Cas10 activity is regulated by complex assembly, the nucleophile selectivi...
Digital twins to accelerate target identification and drug development for immune-mediated disorders [0.03%]
数字孪生加速自身免疫性疾病靶点识别与药物研发
Anna Niarakis,Philippe Moingeon
Anna Niarakis
Immune-related/mediated disorders (IDs) comprise a very diverse group of diseases affecting millions worldwide. The complexity and heterogeneity of IDs, coupled with individual variability in immune system responses, create multiple challen...