Long-term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis [0.03%]
外科脓毒症小鼠模型的长期海马损伤和认知障碍
Dong Seong Cho,Rebecca Schmitt,Aneesha Dasgupta et al.
Dong Seong Cho et al.
Cognitive impairment in sepsis survivors is a growing clinical challenge as the number of sepsis cases rise and acute mortality rates fall. It is estimated that up to 70% of sepsis patients experience cognitive dysfunction and many report p...
RETRACTION: Downregulation of SUMO2 inhibits hepatocellular carcinoma cell proliferation, migration and invasion [0.03%]
撤回：SUMO2表达沉默可抑制肝癌细胞增殖、迁移和侵袭
J. Chen, C. Chen, Y. Lin, Y. Su, X. Yu, Y. Jiang, Z. Chen, SY. Ke, SZ. Lin, L. Chen, Z. Zhang, and T. Zhang, "Downregulation of SUMO2 inhibits hepatocellular carcinoma cell proliferation, migration and invasion," FEBS Open Bio 11, no. 6 (20...
Timothy Lin Yun Tan,Mattias Wei Ren Kon,Xavier Coumoul et al.
Timothy Lin Yun Tan et al.
Postdoctoral supervision and research leadership are crucial yet underexamined dimensions of academic work. In this perspectives piece, we reflect on mentorship across Singapore and France and situate it within output-driven research ecosys...
Development of human monoclonal antibodies against TARM1 by yeast display [0.03%]
酵母呈现技术开发针对TARM1的人源单克隆抗体
Rikio Yabe,Mayumi Saeki,Masaaki Hashiguchi et al.
Rikio Yabe et al.
TARM1, a leukocyte immunoglobulin-like receptor expressed on myeloid cells, functions as a costimulatory receptor promoting proinflammatory cytokine secretion. Recent studies have revealed the involvement of TARM1 in immune-mediated disease...
Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1 [0.03%]
鉴定调控人类MRP4基础表达的转录因子强调Sp1的重要作用
Debora Singer,Angelique Kragl,Katrin Ziems et al.
Debora Singer et al.
The multidrug resistance protein 4 (MRP4/ABCC4) is a versatile efflux pump, known to transport several drugs but also signaling molecules such as cyclic nucleotides and lipid mediators. Based on this substrate spectrum and its broad tissue ...
Tokio Takaji,Yurika Nakanishi,Nobuhiro Nakamura
Tokio Takaji
Yip domain family (YIPF) proteins are five-pass transmembrane proteins that localize primarily to the Golgi apparatus. These proteins assemble into higher-order complexes with each α-subunit pairing specifically with a β-subunit to form a...
Proteasomal degradation of intracellularly expressed Amblyomin-X limits suicide gene therapy potential in melanoma cells [0.03%]
溶酶体降解胞内表达的Amblyomin-X限制了自杀基因在黑色素瘤细胞治疗中的潜力
Victor Dal Posolo Cinel,Carlos DeOcesano Pereira,Aline Ramos Maia Lobba et al.
Victor Dal Posolo Cinel et al.
Amblyomin-X is a complex Kunitz-type protease inhibitor from the tick Amblyomma sculptum, with selective pro-apoptotic effects in tumor cells. While promising when applied exogenously, its large-scale recombinant production is hindered by s...
Towards environmental sustainability through the production of tailored bioplastics [0.03%]
通过生产定制生物塑料实现环境可持续性
C Valeria L Giosafatto,Raffaele Porta
C Valeria L Giosafatto
Plastic pollution from fossil fuel-derived materials has become a pressing environmental and public health issue, driving urgent demand for sustainable alternatives. Conventional plastics can take centuries to degrade and, instead of breaki...
The skills required for transition to university and study in biological sciences: A student perspective [0.03%]
从学生角度出发看生物科学领域大学入学及学习所需的能力要求
Janella Borrell,Susan Crennell
Janella Borrell
In preparation for a university-wide Curriculum Transformation project across the University of Bath, a survey of student opinions of the skills training they received, required and developed during their bioscience studies was undertaken. ...
Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer [0.03%]
鉴定基因表达谱用于结直肠癌术后辅助化疗的风险分层
Mayuko Otomo,Keisuke Okuno,Shuichi Watanabe et al.
Mayuko Otomo et al.
Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential for guiding the use of postoperative adjuvant chemotherapy (ACT). In this study, we identified...