Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties [0.03%]
FcγRI中正向选择密码子的分子动力学模拟揭示了新的生化结合特性
David A Young,Omar Arias-Gaguancela,Fiona Gibson et al.
David A Young et al.
FcγRI is a high-affinity receptor for IgG, associated with autoimmune disease pathology and determines clinical responses to antibody-based immunotherapies. FcγRI has a complex evolutionary history that is not fully understood, and to add...
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells [0.03%]
RoundMi：一种分析分裂细胞线粒体形态的定量方法
Elmira Parvindokht Bararpour,Christine Volmert,Valentina Piano
Elmira Parvindokht Bararpour
Mitochondrial morphology is a key readout of cellular physiology and pathophysiology, yet its quantitative analysis in mitotic cells remains technically demanding due to their rounded, three-dimensional architecture. Volumetric imaging appr...
Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth [0.03%]
芽孢杆菌属(xylianus)突然厌氧化会增加细胞内活性亚铁离子并抑制细胞生长
Shinya Kimata,Yoichi Sakai,Keisuke Tanaka et al.
Shinya Kimata et al.
Amphibacillus xylanus is an aerotolerant anaerobe that consumes large amounts of oxygen and requires iron as an essential micronutrient during its aerobic growth. However, this bacterium lacks a typical respiratory chain; therefore, intrace...
Lipopolysaccharide uptake is augmented in lipopolysaccharide-tolerant mouse macrophage-like cells via increased CD14 expression [0.03%]
脂多糖耐受的类巨噬细胞系中通过增加CD14表达促进脂多糖吸收
Saeka Nishihara,Takayuki Manabe,Mika Jouta et al.
Saeka Nishihara et al.
Lipopolysaccharide (LPS) tolerance can be recognized as a modulation of innate immune responses rather than merely a hyporesponsiveness to LPS, with CD14 being crucial for both LPS uptake and LPS signaling. In this study, we observed that L...
Derivation and characterization of retinal pigment epithelium from urine-derived iPSCs [0.03%]
尿源性诱导多能干细胞向视网膜色素上皮的分化及其鉴定
Daniella Beiner,Hainan Zhu,Carol Christine Bosholm et al.
Daniella Beiner et al.
Age-related macular degeneration (AMD), particularly its dry form, is a leading cause of irreversible vision loss due to retinal pigment epithelium (RPE) dysfunction and loss. Addressing this unmet therapeutic need requires non-invasive str...
Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling [0.03%]
药理学上靶向PERK途径调节肝细胞癌的生长和免疫信号转导
Ada Lerma-Clavero,Maria Kopsida,Nathalie Arendt et al.
Ada Lerma-Clavero et al.
The unfolded protein response (UPR) plays an important role in tumor progression and cellular stress adaptation. In hepatocellular carcinoma (HCC), pharmacological inhibition of the protein kinase R-like endoplasmic reticulum kinase (PERK) ...
One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH-SY5Y and U-87 MG cancer cells [0.03%]
“因人而异：贝扎菲布和甲羟孕酮对SH-SY5Y和U-87 MG癌细胞的体外影响研究”
Abhishek Kharawatkar,Francesco Michelangeli,Farhat Latif Khanim et al.
Abhishek Kharawatkar et al.
Here, we have examined the effects of the repurposed drugs bezafibrate (BEZ) and medroxyprogesterone acetate (MPA) singly and in combination (BaP) on a neuroblastoma (SH-SY5Y) and a glioblastoma (U-87 MG) cell line. BaP was previously shown...
Early-life high-fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations [0.03%]
高脂饮食暴露增加跟腱僵硬度并诱导转录组改变
Heyong Yin,Ziyang Yuan,Wenli Jiang et al.
Heyong Yin et al.
High-fat diet (HFD) exposure is a recognized risk factor for tendinopathy and impaired tendon healing in adults, yet its effects on baseline tendon properties following early-life exposure remain poorly understood. In this study, we investi...
Anchorage-independent and faster growth in clonal population from UV-irradiated NER-deficient cells [0.03%]
UV照射NER缺陷细胞来源的克隆群体中独立生长和快速增殖
Paola Perucca,Anna Tricarico,Martina Furfaro et al.
Paola Perucca et al.
Human tumours are characterized by both molecular and functional heterogeneity, which drives cancer cell growth. In this context, the selection of subclones that acquire enhanced proliferative capacity and resistance to pharmacological trea...