Prognostic biomarker identification and tumor classification in breast cancer patients by methylation and transcriptome analysis [0.03%]
基于甲基化和转录组分析的乳腺癌患者预后生物标志物鉴定及肿瘤分类
Xiongdong Zhong,Guoying Zhong
Xiongdong Zhong
Breast cancer is one of the most common and heterogeneous malignancies. Although the prognosis of breast cancer has improved with the development of early screening, the mechanisms underlying tumorigenesis and progression remain incompletel...
C188-9 reduces TGF-β1-induced fibroblast activation and alleviates ISO-induced cardiac fibrosis in mice [0.03%]
C188-9抑制TGF-β1诱导的成纤维细胞活化及异丙肾上腺素致小鼠心脏纤维化的作用研究
Jiao Liu,Yuxuan Jin,Bei Wang et al.
Jiao Liu et al.
Cardiac fibrosis is the final event of heart failure and is associated with almost all forms of cardiovascular disease. Cardiac fibroblasts (CFs), a major cell type in the heart, are responsible for regulating normal myocardial function and...
Analogs of imine resveratrol alleviate oxidative stress-induced neurotoxicity in PC12 cells via activation of Nrf2 [0.03%]
茋类似物通过激活Nrf2缓解PC12细胞中的氧化应激诱导的神经毒性
Yin Zhang,Zhixiong Wang,Jiehong Yang et al.
Yin Zhang et al.
Oxidative stress is closely associated with neurodegenerative, cardiovascular and metabolic diseases. Resveratrol and related compounds have shown great potential as antioxidants via either direct scavenging of abundant reactive oxygen spec...
The mitochondrial fission factor FIS1 promotes stemness of human lung cancer stem cells via mitophagy [0.03%]
线粒体分裂因子FIS1通过线粒体自噬促进人肺癌干细胞的干性特征
Doudou Liu,Zhiwei Sun,Ting Ye et al.
Doudou Liu et al.
Mitophagy, a form of autophagy, plays a role in cancer development, progression and recurrence. Cancer stem cells (CSCs) also play a key role in these processes, although it not known whether mitophagy can regulate the stemness of CSCs. Her...
Activation of the mitogen-activated protein kinase ERK1/2 signaling pathway suppresses the expression of ChREBPα and β in HepG2 cells [0.03%]
ERK1/2信号通路活化抑制HepG2细胞内ChREBPα和β的表达
Lan Li,Haruhiko Sakiyama,Hironobu Eguchi et al.
Lan Li et al.
The carbohydrate response element-binding protein (ChREBP), a glucose-responsive transcription factor that plays a critical role in the glucose-mediated induction of genes involved in hepatic glycolysis and lipogenesis, exists as two isofor...
Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway [0.03%]
lipoxin A4通过激活Akt/Nrf2/HO-1信号通路保护原发性脊髓神经元免受Erastin诱导的铁死亡损伤
Na Wei,Tan Lu,Libin Yang et al.
Na Wei et al.
Ferroptosis is an iron-dependent programmed cell death, which participates in the pathogenesis of spinal cord injury (SCI). Our previous study has revealed that Lipoxin A4 (LXA4) exerts a protective role in SCI. Here, we investigated whethe...
Alterations in circulating extracellular vesicles underlie social stress-induced behaviors in mice [0.03%]
循环细胞外囊泡的变化介导了小鼠社会压力诱导的行为反应
Shinji Sakamoto,Dania Mallah,Destynie J Medeiros et al.
Shinji Sakamoto et al.
Chronic stress induces peripheral and intracerebral immune changes and inflammation, contributing to neuropathology and behavioral abnormalities relevant to psychiatric disorders such as depression. Although the pathological implication of ...
Expression and cell transformation activity of dynactin-associated protein isoforms [0.03%]
动力蛋白相关蛋白异构体的表达及细胞转化活性
Xiaobo Yin,Shota Yamada,Hiroaki Kobayashi et al.
Xiaobo Yin et al.
Overexpression of human dynactin-associated protein isoform a (dynAPa) transforms NIH3T3 cells. DynAPa is a single-pass transmembrane protein with a carboxy-terminal region exposed to the outside of cells. According to the NCBI RefSeq datab...
Stereospecificity of hydride transfer and molecular docking in FMN-dependent NADH-indigo reductase of Bacillus smithii [0.03%]
芽孢杆菌Smithii依赖FMN的NADH-靛红还原酶的氢化物转移立体专一性及分子对接研究
Kazunari Yoneda,Haruhiko Sakuraba,Tomohiro Araki et al.
Kazunari Yoneda et al.
In this study, we investigated the stereospecificity of hydride transfer from NADH to flavin mononucleotide (FMN) in reactions catalyzed by the FMN-dependent NADH-indigo reductase expressed by thermophilic Bacillus smithii. We performed 1 H...
Genomic analysis of Neisseria elongata isolate from a patient with infective endocarditis [0.03%]
从感染性心内膜炎患者分离的奈瑟菌素elongata基因组分析
Marcos André Schörner,Hemanoel Passarelli-Araujo,Mara Cristina Scheffer et al.
Marcos André Schörner et al.
Neisseria elongata is part of the commensal microbiota of the oropharynx. Although it is not considered pathogenic to humans, N. elongata has been implicated in several cases of infective endocarditis (IE). Here, we report a case of IE caus...
Case Reports
FEBS open bio. 2021 Jul;11(7):1987-1996. DOI:10.1002/2211-5463.13201 2021