Ferroptosis-based nano-assembly enhanced breast cancer therapy by inhibiting intratumor bacteria [0.03%]
基于铁死亡的纳米组装通过抑制瘤内细菌增强乳腺癌治疗
Yao Qi,Yue Qiu,Yuting Zhang et al.
Yao Qi et al.
Intratumoral bacteria, especially Gram-positive bacteria (G+), have a unique bacterial niche in breast cancer that promoted tumor progression. However, the effects of G+ have so far been overlooked, serving an "invisible driver" of breast c...
Inhibition of PGK1 enhances sensitivity to tyrosine kinase inhibitor in T315I-mutant leukemia [0.03%]
PGK1抑制能提高T315I突变型白血病对酪氨酸激酶抑制剂的敏感性
Huijing Wang,Fengyu Jiang,An Pan et al.
Huijing Wang et al.
Phosphoglycerate kinase 1 (PGK1) is traditionally recognized for its pivotal role in glycolysis. Our findings reveal that PGK1 also functions as a protein kinase phosphorylating valosin-containing protein (VCP) at S746, which subsequently r...
Multivalent sulphur-modified biosilica nanostructures for bacterial enteritis therapy [0.03%]
用于细菌性肠炎治疗的多元硫修饰生物二氧化硅纳米结构
Tongyi Zhao,Xiaoxi Fan,Haijia Hou et al.
Tongyi Zhao et al.
Bacterial enteritis is a specific gastrointestinal tract disorder caused by pathogenic bacterial infection, which not only disrupts the commensal microbiota but also contributes to cascaded complications. Here, we prepared polyethyleneimine...
Aptamers targeting respiratory syncytial virus showed high inhibitory activity by blocking the G protein [0.03%]
针对呼吸道合胞病毒的拮抗适配体通过阻断G蛋白发挥高抑制活性
Ge Yang,Guangyu Jiang,Xintao Lian et al.
Ge Yang et al.
Respiratory syncytial virus (RSV) is a major global health threat, causing severe respiratory disease in infants, the elderly, and immunocompromised individuals-often surpassing the impact of influenza. Yet, effective RSV therapies remain l...
Targeting RNA binding proteins with small-molecule inhibitors: Advances, challenges, and therapeutic opportunities [0.03%]
靶向RNA结合蛋白的小分子抑制剂：进展、挑战和治疗机会
Yuning Shi,Dazhi Feng,Jieya Zhou et al.
Yuning Shi et al.
RNA-binding proteins (RBPs) constitute central regulators of post-transcriptional gene expression and have been increasingly recognized as critical contributors to the pathogenesis of cancer, neurodegenerative disorders, and autoimmune dise...
PhenoModel: A multimodal phenotypic drug design foundation model for discovering novel potential inhibitors of multiple cancer cells [0.03%]
PhenoModel：一种多模态表型药物设计基础模型，用于发现针对多种癌细胞的新型潜在抑制剂
Shihang Wang,Qilei Han,Weichen Qin et al.
Shihang Wang et al.
Phenotypic drug discovery (PDD) focuses on the observable traits or phenotype of cells or organisms in response to drug treatment, rather than relying primarily on specific molecular targets. Drugs discovered through this approach may have ...
Multi-omics-based identification of METTL11B as a novel biomarker in esophageal squamous cell carcinoma [0.03%]
基于多组学的METTL11B蛋白作为食管鳞癌新型生物标志物的研究
Wenke Jin,Hongyao Li,Yanmei Chen et al.
Wenke Jin et al.
The transcriptional regulatory network involved in periderm-specific tanshinones biosynthesis in Salvia miltiorrhiza root [0.03%]
参与重楼根中特异性丹参酮生物合成的转录调控网络
Yajing Li,Peng Di,Yinan Zou et al.
Yajing Li et al.
Tanshinones (TAs), well-known specialized diterpenoid metabolites in Salvia plants, exhibit distinct tissue-specific production in the root periderm. However, the mechanisms regulating this accumulation pattern remain unknown. Here, we empl...
Reversibly unlocking the blood-brain barrier: A study on microtubule dynamics modulation using gold nanoparticle-modified reduced graphene oxide [0.03%]
利用修饰金纳米粒子的还原型石墨烯氧化物可逆打开血脑屏障研究——针对微管动态的研究
Junrong Wu,Guangman Cui,Zhousheng Lin et al.
Junrong Wu et al.
The blood-brain barrier (BBB) is a crucial biological interface between the central nervous system and circulation, playing a key role in maintaining the brain's homeostasis and function, but presenting a challenge for drug delivery. Althou...