Leveraging vascular normalization via eNOS activation to enhance the efficacy of PD-L1 blockade [0.03%]
通过激活eNOS来利用血管正常化以增强PD-L1阻断的疗效
Yang Zhou,Huile Gao
Yang Zhou
Bacterial extracellular vesicles as bioactive nanocarriers for wound treatment [0.03%]
细菌外泌体作为生物活性纳米载体在伤口治疗中的应用
Yejiao Shi,Zelin Zheng,Yuting Li et al.
Yejiao Shi et al.
Bacterial extracellular vesicles (BEVs) secreted by bacteria are considered as messengers for the crosstalk between gut microbiota and wounded skin via the "gut-skin axis". The BEVs with the lipid bilayer nanostructures can deliver various ...
Yan Jia,Qingtian Zhu,Qiong Pan et al.
Yan Jia et al.
The liver and pancreas are metabolically intertwined organs whose bidirectional communication is critical for maintaining systemic homeostasis. Dysregulation of this inter-organ crosstalk is a central driver in the pathology of a growing li...
Metal-polyphenol network-based multifunctional materials for tumor therapy: Intrinsic properties, advances, and applications [0.03%]
金属-多酚网络基多功能材料的肿瘤治疗研究：内在属性、进展与应用展望
Chen Ma,Qian Xu,Lingwen Ding et al.
Chen Ma et al.
Metal-polyphenol networks (MPNs), a novel class of nano-biomaterials, have recently emerged as promising candidates for tumor diagnosis and therapy due to their unique chemical tunability, excellent biocompatibility, and synergistic multifu...
AI-integrated microfluidics for drug screening: From single cell to organ-on-a-chip [0.03%]
人工智能融合的微流控芯片技术在药物筛选中的应用：从单细胞到器官芯片
Hongyun Yin,Zheyu Li,Zinuo Shen et al.
Hongyun Yin et al.
Drug discovery remains a protracted and capital-intensive process, primarily hindered by inefficiencies in drug screening. Microfluidic technology provides a promising approach for in vitro drug screening, enabling physiologically relevant,...
Heterocyclic modified paclitaxel prodrug nanoassemblies for stimuli-responsive delivery via lysosomal escape [0.03%]
基于溶酶体逃逸刺激响应递送的杂环改性紫杉醇前药纳米组装体
Mingyang Han,Hezhen Xu,Jun Yuan et al.
Mingyang Han et al.
Prodrug nanoassemblies offer an innovative approach to drug delivery, but their lysosomal entrapment often impairs drug release. Notably, tertiary amine structures can undergo protonation reactions, thereby facilitating lysosomal escape thr...
Exploiting eNOS activation to achieve tumor vascular normalization via endothelial transcytosis of lipid nanoparticles [0.03%]
利用eNOS激活通过内皮细胞脂质纳米颗粒跨细胞转运实现肿瘤血管正常化
Huisong Hao,Yunfei Yi,Yanan Fu et al.
Huisong Hao et al.
Abnormal tumor vasculature greatly accelerates tumor progression and diminishes antitumor treatments. Restoring perivascular NO gradients is available to maintain tumor vessel homeostasis and promote tumor vascular normalization. However, e...
Dichotomous role of CD47-SIRP α axis: Leveraging opposing functions in phagocytic resistance and transport assistance for enhanced nanocarrier biocompatibility and tumor penetration [0.03%]
CD47-SIRPα轴的双重作用：利用相反的功能增强纳米载体的生物相容性和肿瘤渗透性
Xuehui Duan,Yixuan Tang,Zhongjie Tang et al.
Xuehui Duan et al.
Polyethylene glycol (PEG) carriers can improve drug circulation, but encounter biocompatibility and tumor penetration challenges. The CD47-SIRPα interaction on macrophages can initiate a "don't-eat-me" signal, inhibiting phagocytosis. This...
Vitamin A and its analogues modulate MUFAs metabolism to improve ferroptosis and aging by direct targeting of ACSL3 [0.03%]
维生素A及其类似物通过直接靶向ACSL3调节单不饱和脂肪酸代谢以改善铁死亡和衰老
Nanxuan Luo,Yijie Xiao,Yile Zhai et al.
Nanxuan Luo et al.
In our screening campaign for novel ferroptosis inhibitors, we identified that vitamin A (VA) and its metabolite all-trans retinoic acid (ATRA) exhibited potent ferroptosis-suppressing activity. Notably, through a combination of biochemical...
A triple combination strategy for nasopharyngeal carcinoma: Aptamer-guided liposomal chemotherapy, engineered NK cells, and Fc-enhanced PD-L1 antibody therapy [0.03%]
一种针对鼻咽癌的三管齐下策略：适配体导向脂质体化学治疗、改造型NK细胞以及增强型PD-L1抗体疗法
Chaoyan Yao,Lei Wang,Weidong Liu et al.
Chaoyan Yao et al.
The effective treatment of nasopharyngeal carcinoma (NPC) is challenged by an immunosuppressive tumor microenvironment (TME) and insufficient immune effector cell activation. Herein, we design a synergistic tri-modal therapeutic strategy to...