SIM: Discovery of novel RNA-targeting argonautes by self-iterative learning from scarce data [0.03%]
SIM：通过自我迭代学习从稀缺数据中发现新的RNA靶向.ArgoNAUTES
Shuze Peng,Feiming Huang,Nuolan Li et al.
Shuze Peng et al.
The limited repertoire of experimentally validated RNA-targeting nucleases has constrained both mechanistic studies and the efficient discovery of novel enzymes for RNA biotechnology. This challenge is particularly pronounced for prokaryoti...
From conceptual design to translational progress: Emerging advances in intelligent microneedles for biomedical applications [0.03%]
从概念设计到转化进展：用于生物医学应用的智能微针的新兴进展
Yue Yin,Qiaoqiao Zhao,Zihan Wang et al.
Yue Yin et al.
Microneedles (MNs), as innovative biomedical devices, are undergoing a transformation from basic transdermal devices to intelligent and multifunctional systems. The advancement of intelligent MNs enhances tissue penetration and adhesion, tr...
Self-assembled nanoplatforms for cancer immunotherapy: Principles, progress and perspectives [0.03%]
癌症免疫治疗的自组装纳米平台：原理、进展和展望
Wenfei Xu,Shuxuan Zhu,Zhaogang Sun et al.
Wenfei Xu et al.
Cancer immunotherapy is an innovative treatment approach that leverages the immune system's ability to identify and attack tumor cells. Its goal is to initiate or re-establish the tumor-immune cycle. However, challenges such as limited resp...
An oral immune enhancer with excellent biocompatibility for effectively strengthening body's immunity and treating cancer [0.03%]
一种生物相容性优异的口服免疫增强剂有效提升人体免疫力并治疗癌症
Anqi Xie,Lei Feng,Yaping Shao et al.
Anqi Xie et al.
Enhancing immunity offers a versatile yet effective strategy for treating or preventing diseases. Here, we obtained a new polysaccharide (AFP-80) from Anoectochilus formosanus that unexpectedly stimulated immune systems without causing any ...
Isoalantolactone induces AML pyroptosis and potentiates α-PD-1 efficacy by targeting selenoprotein TXNRD1 [0.03%]
异阿尔antalactone通过靶向硒蛋白TXNRD1诱导AML细胞焦亡并增强α-PD-1疗效
Xiaoxuan Yu,Yanyu Zhou,Shibo Sun et al.
Xiaoxuan Yu et al.
The suppressive microenvironment of AML limits anti-PD-1 efficacy, making pyroptosis induction a key strategy for its remodeling. Isoalantolactone (IAL), a naturally occurring small molecule, has been identified herein to inhibit cytosolic ...
Daniélle van Staden,Hendrik J R Lemmer,Wilna Liebenberg et al.
Daniélle van Staden et al.
Advancements in drug discovery, such as artificial intelligence, computational technology, and combinatorial chemistry, have led to numerous new promising drug candidates. However, most still fail to reach the market due to poor physicochem...
Targeted intestinal barrier repair via probiotic-derived engineered outer membrane vesicles: A 3A1M strategy with antioxidant, anti-inflammatory, anti-ferroptotic, and microbiome modulation effects [0.03%]
一种针对肠道屏障修复的益生菌工程外膜囊策略：具有抗氧化、抗炎、抗铁死亡和调节微生物群作用的3A1M策略
Li Yu,He Zhang,Chengge Shi et al.
Li Yu et al.
Intestinal barrier disruption, driven by oxidative stress, ferroptosis, immune imbalance, and gut microbiota dysbiosis, plays a crucial role in inflammatory bowel disease (IBD) pathogenesis. Current treatments are often ineffective and caus...
From target specificity to metabolic efficiency: Design and optimization of etomidate analogues for potential improvement in postoperative outcomes [0.03%]
从靶点特异性到代谢动力学效率：依托咪酯类药物的设计与优化以改善术后结果的可能性研究
Yi Zhao,Wei Ai,Jieyu Zhao et al.
Yi Zhao et al.
While transient perioperative side effects of intravenous anesthetics are often tolerated, the persistent postoperative sequelae resulting from drug accumulation pose a critical threat to patient safety. Etomidate, introduced in the 1970s, ...