Advances of microneedle technology for the treatment of autoimmune diseases [0.03%]
微针技术在自身免疫性疾病治疗中的应用进展
Ying Chen,Yanping Fu,Xinyu Wen et al.
Ying Chen et al.
Autoimmune diseases are characterized by an aberrant immune response directed against the body's own components, leading to immune dysfunction and loss of tolerance. This ultimately results in tissue damage and organ impairment. Despite the...
Inhaled nucleic acid delivery systems for the treatment of pulmonary interstitial diseases: Challenges and opportunities [0.03%]
肺间质疾病的吸入型核酸递送系统：挑战与机遇
Jingwen Dong,Jiahui Chen,Junmei Mu et al.
Jingwen Dong et al.
The treatment of interstitial lung diseases (ILDs) was important to reduce the inflammation or fibrosis within the interstitial space. In recent years, a variety of undruggable ILDs targets were emerged for anti-inflammation and anti-fibros...
Erratum: Author correction to "The crucial function of IDO1 in pulmonary fibrosis: from the perspective of mitochondrial fusion in lung fibroblasts and targeted molecular inhibition" [Acta Pharmaceutica Sinica B 15 (2025) 3125-3148] [0.03%]
撤稿：肺纤维化中IDO1的关键功能：从肺成纤维细胞线粒体融合及靶向分子抑制的角度出发（第15卷，2025年，第3125-3148页）
Lei Wang,Shanchun Ge,Ye Zhang et al.
Lei Wang et al.
[This corrects the article DOI: 10.1016/j.apsb.2025.04.027.]. © 2026 The Authors.
Published Erratum
Acta pharmaceutica Sinica. B. 2026 Apr;16(4):2598-2599. DOI:10.1016/j.apsb.2026.01.036 2026
Engineered bacteria reprogram tumor microenvironment via cell senescence and neutrophil extracellular traps degradation [0.03%]
通过细胞衰老和中性粒细胞胞外陷阱降解工程菌重新编程肿瘤微环境
Wanfa Dong,Chenyang Li,Jiqiang Lu et al.
Wanfa Dong et al.
Attenuated Salmonella VNP20009 (VNP) shows promising anti-cancer therapeutic potential. Limited understanding of its anti-tumor mechanism has hindered broader clinical application. Recent studies have reported cellular senescence is involve...
Engineered apoptotic vesicle mimetics with tunable "eat-me" signaling precisely regulate tumor-associated macrophages for potentiating cancer immunotherapy [0.03%]
工程化凋亡小体仿生纳米粒通过调控“吃我”信号精准重编程肿瘤相关巨噬细胞以增强癌症免疫治疗
Yu Liu,Chunbai Xiang,Yeneng Dai et al.
Yu Liu et al.
Repolarizing immunosuppressive M2-phenotype tumor-associated macrophages (TAMs) and blocking the CD47/SIRPα axis are promising strategies to enhance cancer immunotherapy. However, non-selective disruption of macrophage phenotypic balance a...
Aberrant astroglial Kir4.1 activation in the anterior cingulate cortex disrupts neuronal excitability and social behavior [0.03%]
前扣带回Kir4.1通道激活异常通过干扰神经元兴奋性而导致社交行为障碍
Zhengmao Li,Yixuan Zhang,Yan Chen et al.
Zhengmao Li et al.
Prenatal herbicide exposure is increasingly linked to neurodevelopmental disorders, yet effective pharmacological interventions remain lacking due to unclear pathogenic mechanisms. Here, we demonstrate that prenatal exposure to glufosinate ...
Recent advances in biomedical applications of lyotropic liquid crystals [0.03%]
手性溶致液晶在生物医学应用中的最新研究进展
Guojin Liu,Yuanmei Yang,Qing Wu et al.
Guojin Liu et al.
Lyotropic liquid crystals (LLCs), formed through the self-assembly of amphiphilic molecules in polar solvents, offer thermodynamic stability and tunable mesophases (lamellar, hexagonal, and cubic), making them a versatile platform for biome...
Generative active learning guided discovery of a tobramycin and ciprofloxacin adjuvant against multidrug-resistant Pseudomonas aeruginosa infections [0.03%]
生成主动学习引导发现针对多药耐药铜绿假单胞菌感染的托溴铵和环丙沙星增效剂
Siyu Zhao,Jie Tang,Ziyang Du et al.
Siyu Zhao et al.
Biofilm-mediated resistance in multidrug-resistant (MDR) Pseudomonas aeruginosa infections severely compromise antibiotic efficacy in clinical applications. Antibacterial adjuvants represent a promising strategy to restore antibiotic sensit...
Deciphering the biological fate of mRNA-LNP-based biologics: A perspective from tissue to intracellular distribution [0.03%]
mRNA脂质纳米粒生物药体内组织及细胞水平分布研究展望
Xin Xu,Lili Cui,Yong Zhang et al.
Xin Xu et al.
The remarkable clinical success of mRNA-lipid nanoparticle (mRNA-LNP) vaccines, particularly evidenced by their pandemic-era impact and subsequent 2023 Nobel Prize recognition, has intensified global efforts to expand their application towa...
A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function [0.03%]
一种神经紧张素受体1片段肽拟剂作为偏向性变构调节剂来调控靶标受体的功能
Rebecca L Brouillette,Frédérique Lussier,Émile Breault et al.
Rebecca L Brouillette et al.
Pepducins are synthetic membrane-tethered lipopeptides designed to allosterically modulate G protein-coupled receptor (GPCR) signaling. Here, we characterize a series of pepducins targeting the neurotensin receptor type 1 (NTSR1), revealing...